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Browse our CPT1A Proteins (CPT1A)

Full name:
Carnitine Palmitoyltransferase 1A (Liver) Proteins (CPT1A)
On www.antibodies-online.com are 13 Carnitine Palmitoyltransferase 1A (Liver) (CPT1A) Proteins from 5 different suppliers available. Additionally we are shipping CPT1A Antibodies (117) and CPT1A Kits (19) and many more products for this protein. A total of 158 CPT1A products are currently listed.
Synonyms:
C730027G07, CPT-Ia, Cpt1, CPT1-L, CPTI, L-CPT1, L-CPTI, MGC53498, si:dkey-56p7.8
list all proteins Gene Name GeneID UniProt
CPT1A 1374 P50416
CPT1A 12894 P97742
CPT1A 25757 P32198

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CPT1A Proteins (CPT1A) by Origin

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Human Carnitine Palmitoyltransferase 1A (Liver) (CPT1A) interaction partners

  1. Methylation at 2 CpG sites in CPT1A on chromosome 11 was significantly associated with MetS. Significant associations were replicated in both European and African ancestry participants.

  2. CPT1 is active on the outer surface of mitochondria and serves as a regulatory site for fatty acid oxidation due to its sensitivity for malonyl-CoA. CPT1a is the hepatic isoform.

  3. the structure of the regulatory domain of CPT1C (show CPT1C Proteins) was determined (residues Met1 (show GZMM Proteins)-Phe50) by NMR spectroscopy.

  4. Targeting the leukemia cell metabolism by the CPT1a inhibition

  5. This large-scale epigenome-wide study discovered and replicated robust associations between DNA methylation (show HELLS Proteins) at CpG loci and obesity indices

  6. CPT1A inhibition with RNAi resulted in triglyceride accumulation in HepG2 cells. The CPT1A promoter region was determined to contain two putative Sp1 (show PSG1 Proteins) binding sites, namely Sp1a and Sp1b, which might act as the GBE (show GBE1 Proteins) regulation response DNA element.

  7. The present study was designed to evaluate the involvement of hexokinase and CPT-1 in the cell growth and proliferation of human prostate cancer cell lines, PC3 (show PCSK1 Proteins), and LNCaP-FGC-10.

  8. CPT1A methylation was strongly associated with fasting very-low low-density lipoprotein cholesterol and trigylcerides.

  9. High grade glioblastoma is associated with increased level of ZFP57, a protein involved in gene imprinting, and aberrant expression of CPT1A and CPT1C (show CPT1C Proteins).

  10. The results suggest the generality of carnitine palmitoyltransferase-1 inhibition under various stress conditions associated with ROS (show ROS1 Proteins) generation, providing an insight into a mechanism for oxidative dysfunction in mitochondrial metabolism.

Pig (Porcine) Carnitine Palmitoyltransferase 1A (Liver) (CPT1A) interaction partners

  1. acetate is the primary product of hepatic mitochondrial beta-oxidation in Sus scrofa and that regulation during early development is mediated primarily via kinetic modulation of CPT I (show CPT1B Proteins)

Cow (Bovine) Carnitine Palmitoyltransferase 1A (Liver) (CPT1A) interaction partners

  1. This study evaluated the effects of nonesterified fatty acids and glucose on carnitine palmitoyltransferase-I (CPT-I) mRNA expression in cultured bovine hepatocytes using real-time reverse transcription polymerase chain reaction and ELISA methods.

  2. It was conclude that suppression of CPT (show DHDDS Proteins) activity by positive energy balance appears to be specific for the liver in mid-lactating dairy cows.

Mouse (Murine) Carnitine Palmitoyltransferase 1A (Liver) (CPT1A) interaction partners

  1. these results demonstrated that L-carnitine ameliorated liver inflammation and serum pro-inflammatory markers in cancer cachexia through regulating CPT I-dependent PPARg (show PPARG Proteins) signaling

  2. -Carnitine exerts its ameliorative effects in cancer cachexia in association with the PPAR-gamma (show PPARG Proteins) signaling pathway.

  3. Data show that peroxisome-proliferator-activated receptor beta (show PPARD Proteins)/delta (PPARbeta (show PPARD Proteins)/delta) activation restored the lipid-induced endothelial dysfunction by up-regulation of carnitine palmitoyltransferase)-1 (CPT-1).

  4. Our results indicated that exercise-induced CPT1b (show CPT1B Proteins) expression was at least in part mediated by HDAC5 (show HDAC5 Proteins)/MEF2A (show MEF2A Proteins) interaction.

  5. an environment-dependent structural switch underlies the regulation of carnitine palmitoyltransferase 1A

  6. miR (show MLXIP Proteins)-370 acting via miR (show MLXIP Proteins)-122 may have a causative role in the accumulation of hepatic triglycerides by modulating initially the expression of SREBP-1c (show SREBF1 Proteins), DGAT2 (show DGAT2 Proteins), and Cpt1alpha.

  7. Results show that CREB and HNF4alpha bind the CPT promoter, that PGC-1 is involved in liver carnitine palmitoyltransferase I (CPT) gene activation by cylic AMP, and that PGC-1 acts to coordinate the process of metabolic adaptation in the liver.

  8. role of thyroid hormone (show PTH Proteins) response unit formed between the promoter and first intron in mediating liver-specific induction by thyroid hormone (show PTH Proteins)

  9. Malonyl-CoA/CPTI interaction is a component of a metabolic signaling network that controls insulin (show INS Proteins) secretion.

  10. modulation of CPT1A expression by PI3K-dependent signaling is the major mechanism by which cells suppress beta-oxidation during anabolic growth

CPT1A Protein Profile

Protein Summary

The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with CPT1A

  • carnitine palmitoyltransferase 1A (liver) (cpt1a)
  • carnitine palmitoyltransferase 1A (liver) (CPT1A)
  • carnitine palmitoyltransferase 1a, liver (Cpt1a)
  • C730027G07 protein
  • CPT-Ia protein
  • Cpt1 protein
  • CPT1-L protein
  • CPTI protein
  • L-CPT1 protein
  • L-CPTI protein
  • MGC53498 protein
  • si:dkey-56p7.8 protein

Protein level used designations for CPT1A

carnitine palmitoyltransferase 1A (liver) , carnitine O-palmitoyltransferase 1, liver isoform-like , CPT I , CPTI-L , carnitine O-palmitoyltransferase 1, liver isoform , carnitine O-palmitoyltransferase I, liver isoform , carnitine palmitoyltransferase I, liver , carnitine palmitoyl transferase I liver isoform , liver type carnitine palmitoyltransferase I , mitochondrial carnitine palmitoyltransferase 1A , carnitine palmitoyltransferase 1A , carnitine palmitoyltransferase I , carnitine palmitoyl transferase I isoform , CPT1-L , L-CPT I , carnitine palmitoyltransferase 1, liver , Carnitine palmitoyltransferase 1 alpha, liver isoform

GENE ID SPECIES
379393 Xenopus laevis
451382 Pan troglodytes
709837 Macaca mulatta
100135089 Xenopus (Silurana) tropicalis
100403111 Callithrix jacchus
100554332 Anolis carolinensis
100588984 Nomascus leucogenys
1374 Homo sapiens
399527 Sus scrofa
506812 Bos taurus
558088 Danio rerio
423118 Gallus gallus
403583 Canis lupus familiaris
100009716 Equus caballus
12894 Mus musculus
25757 Rattus norvegicus
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