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anti-Human EEF2 Antibodies:
anti-Mouse (Murine) EEF2 Antibodies:
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Human Monoclonal EEF2 Primary Antibody for ICC, IHC - ABIN969090
Maggi, Kuchenruether, Dadey, Schwope, Grisendi, Townsend, Pandolfi, Weber: Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. in Molecular and cellular biology 2008
Show all 2 references for ABIN969090
Caenorhabditis elegans (C. elegans) Polyclonal EEF2 Primary Antibody for IHC, WB - ABIN2787690
Tu, Yan, Hood, Lin: Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells. in Molecular & cellular proteomics : MCP 2007
These results suggest that binding of eEF2 to the ribosome alters its conformation, resulting in a weakened affinity of eIF5A (show EIF5 Antibodies) and impairment of this interplay compromises cell growth due to translation elongation defects.
nuclear localization of active eEF-2 depends upon its interaction with p53 (show TP53 Antibodies), as cells lacking p53 (show TP53 Antibodies) contain less active eEF-2 in the nuclear compartment
High serum eukaryotic elongation factor 2 level is associated with non-small cell lung cancer.
Results indicated that the eEF2 gene is overexpressed in the majority of several types of cancers and plays an oncogenic role in cancer cell growth.
The expression levels of three putative HA-regulated proteins (TALDO, ANXA1 (show ANXA1 Antibodies) and EF2) in control, H2O2-, HA- and HA/H2O2-treated OA chondrocytes were verified by Western blotting and the results indeed support the notion that HA acts in anti-oxidation
Data indicate that the accumulation of the cleaved C-terminal small fragment of eukaryotic elongation factor 2 (eEF2) in the nucleus, and C-terminal Src kinase (Csk (show CSK Antibodies)) could enhance the proteolytic cleavage of eEF2.
Thiopental inhibits global protein synthesis by repression of eukaryotic elongation factor 2 and protects from hypoxic neuronal cell death.
A single amino acid substitution in eukaryotic elongation factor 2 co-segregates with the disease phenotype of spinocerebellar ataxia (show USP14 Antibodies) 26.
EEF2 phosphorylation by cyclin A (show CCNA2 Antibodies)-cyclin-dependent kinase 2 (CDK2 (show CDK2 Antibodies)) on a novel site, serine 595 (S595), directly regulates T56 phosphorylation by eEF2K (show EEF2K Antibodies).
Burn induces prolonged activation of eEF2K (show EEF2K Antibodies) and eEF2 in pediatric patients.
IL-6 (show IL6 Antibodies) induces the activation of the Stat3 (show STAT3 Antibodies) signaling and promotes the downmodulation of the p90RSK (show RPS6KA1 Antibodies)/eEF2 and mTOR (show FRAP1 Antibodies)/p70S6K (show RPS6KB1 Antibodies) axes, while it does not affect the activation of AKT (show AKT1 Antibodies).
AMPKalpha2 (show PRKAA2 Antibodies) controls cardiac p70S6K (show RPS6KB1 Antibodies) under normoxia and regulates eEF-2 but not the mTOR (show FRAP1 Antibodies)-p70S6K (show RPS6KB1 Antibodies) pathway during ischemia.
The MKK3 (show MAP2K3 Antibodies)/6-p38gamma (show MAPK12 Antibodies)/delta pathway mediated an inhibitory phosphorylation of eukaryotic elongation factor 2 (eEF2) kinase, which in turn promoted eEF2 activation (dephosphorylation) and subsequent TNF-alpha (show TNF Antibodies) elongation.
Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development
induced by basic fibroblast growth factor (show FGF2 Antibodies) via mitogen-activated protein kinase (show MAPK1 Antibodies)
eEF-2 is activated by both lithium and GSK-3 (show GSK3b Antibodies), whereas, lithium treatment and inhibition of GSK-3 (show GSK3b Antibodies) have opposing effects on eEF-2.
eEF-2 phosphorylation has a role in protein synthesis for memory consolidation
A mouse that was mutant for the gene, Dph4 (show DNAJC24 Antibodies), was identified.
exogenous ROS (show ROS1 Antibodies) inhibit mTOR (show FRAP1 Antibodies), eIF2alpha (show EIF2A Antibodies), and eEF2, mTOR (show FRAP1 Antibodies) and eEF2 were largely refractory to ROS (show ROS1 Antibodies) generated under moderate hypoxia (0.5% O(2)).
Eukaryotic elongation factor-2 (eEF2) may be a limiting factor in milk protein (show CSN2 Antibodies) synthesis (Review)
This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation.
eukaryotic translation elongation factor 2
, elongation factor 2-like
, elongation factor 2
, polypeptidyl-tRNA translocase
, elongation factor-2