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Human ELAVL1 Protein expressed in HEK-293 Cells - ABIN2720123
Choudhury, de Lima Alves, de Andrés-Aguayo, Graf, Cáceres, Rappsilber, Michlewski: Tissue-specific control of brain-enriched miR-7 biogenesis. in Genes & development 2013
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GPRC5A (show GPRC5A Proteins) is a potential oncogene (show RAB1A Proteins) in pancreatic ductal adenocarcinoma cells that is upregulated by gemcitabine with help from HuR.
Hur role in the epithelial-to-mesenchymal transition in pancreatic cancer
exposing glioma cells to the HuR inhibitor tanshinone group compound 15,16-dihydrotanshinone-I or to the newly identified compound 5 disrupts HuR multimerization modules and reduces tumor cell survival and proliferation.
We propose that the extensive binding of CircPABPN1 to HuR prevents HuR binding to PABPN1 (show PABPN1 Proteins) mRNA and lowers PABPN1 (show PABPN1 Proteins) translation, providing the first example of competition between a circRNA and its cognate mRNA for an RBP (show RBP4 Proteins) that affects translation.
HuR contributes to efficient oxidative phosphorylation by regulating of CoQ10 biosynthesis.
Data (including data from studies using knockout mice or cells from knockout mice) suggest HUR post-transcriptionally regulates CCR6 (show CCR6 Proteins) expression by binding to and stabilizing CCR6 (show CCR6 Proteins) mRNA and by promoting CCR6 (show CCR6 Proteins) translation in helper T-cells; knock-out of HUR reduces CCR6 (show CCR6 Proteins) expression on helper T-cells, impairs their migration to CNS, and prevents experimental autoimmune encephalomyelitis. (CCR6 (show CCR6 Proteins) = C-C chemokine receptor type 6 (show CCR6 Proteins))
Taken together, our results indicate that HuR activation is an early event in familial adenomatosis polyposis (FAP)--adenoma but is not present in inflammatory bowel disease (IBD)-dysplasia. Furthermore, our results offer a preclinical proof of concept for HuR inhibition as an effective means of FAP chemoprevention, with caution advised in the setting of IBD
Negative regulation of RNA-binding protein (show PTBP1 Proteins) HuR by tumor-suppressor ECRG2 (show SPINK7 Proteins)
Data suggest that ERBB2 (show ERBB2 Proteins) is post-transcriptionally up-regulated in tamoxifen-resistant estrogen receptor (show ESR1 Proteins)-positive breast cancer cells; ERBB2 (show ERBB2 Proteins) expression is decreased post-transcriptionally by miRNA26a/b binding to its 3prime- untranslated region; ERBB2 (show ERBB2 Proteins) expression is increased post-transcriptionally by HuR binding to its 3prime-untranslated region. (ERBB2 (show ERBB2 Proteins) = epidermal growth factor receptor (show EGFR Proteins) 2; HuR = Hu antigen R)
by modulating extracellular export of miR (show MLXIP Proteins)-122, HuR could control stress response in starved human hepatic cells.
STAU1 (show STAU1 Proteins) & STAU2 (show STAU2 Proteins) & ELAVL1 mRNAs & proteins were detected throughout cow preimplantation development (show MTA2 Proteins) from the germinal vesicle (GV) oocyte to the blastocyst stage; ELAVL2 (show ELAVL2 Proteins) mRNAs were detectable from the GV to the morula stage; ELAVL2 (show ELAVL2 Proteins) protein was in all stages
this study reveals a posttranscriptional regulatory mechanism by which RNA-binding protein (show RBM24 Proteins) Elavl1a regulates embryonic erythropoiesis by maintaining appropriate levels of gata1 (show GATA1 Proteins) expression.
Data (including data from studies using knockout mice or cells from knockout mice) suggest HuR post-transcriptionally regulates Ccr6 (show CCR6 Proteins) expression by binding to and stabilizing Ccr6 (show CCR6 Proteins) mRNA and by promoting Ccr6 (show CCR6 Proteins) translation in helper T-cells; knock-out of HuR reduces Ccr6 (show CCR6 Proteins) expression on helper T-cells, impairs their migration to CNS, and prevents experimental autoimmune encephalomyelitis. (Ccr6 (show CCR6 Proteins) = C-C chemokine receptor type 6 (show CCR6 Proteins))
Taken together, our results indicate that HuR activation is an early event in familial adenomatosis polyposis (FAP (show FAP Proteins))--adenoma but is not present in inflammatory bowel disease (IBD)-dysplasia. Furthermore, our results offer a preclinical proof of concept for HuR inhibition as an effective means of FAP (show FAP Proteins) chemoprevention, with caution advised in the setting of IBD
findings indicate a previously unknown interaction between GSK3beta and ELAV-1 during acute respiratory distress syndrome , and suggest the inhibition of the ELAV-1- GSK3beta pathways as a novel acute respiratory distress syndrome treatment approach.
HuR plays a central role in regulating nuclear import of proteins.
These results indicate that HuR promotes early intestinal mucosal repair after injury by increasing Cdc42 (show CDC42 Proteins) translation.
This study uncovers an anti-sense lncRNA (APOA4 (show APOA4 Proteins)-AS), which is co-expressed with APOA4 (show APOA4 Proteins), and concordantly and specifically regulates APOA4 (show APOA4 Proteins) expression both in vitro and in vivo with the involvement of HuR.
These results suggest that the post-transcriptional regulation of ATX (show ENPP2 Proteins) expression by HuR and AUF1 (show HNRNPD Proteins) modulates cancer cell migration.
Results show that HuR is a key regulator of many genes that make up the molecular signature of activated microglia, including increased production of proinflammatory cytokines, chemokines, and migration-associated factors
Results indicate that HuR induces 14-3-3zeta (show YWHAZ Proteins) translation via interaction with its 3' UTR and that 14-3-3zeta (show YWHAZ Proteins) is necessary for stimulation of intestinal epithelial cell migration after wounding.
Knockdown of endogenous HuR protein abrogates the IL-1beta-mediated increase in xCT mRNA half-life.
The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy.
ELAV-like protein 1
, Hu antigen R
, embryonic lethal, abnormal vision, drosophila, homolog-like 1
, hu-antigen R
, ELAV like 1
, ELAV-like 1 (Hu antigen R)
, elav-related A
, embryonic lethal, abnormal vision-related A
, ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)
, HU-antigen A
, elav-like generic protein