ELAVL1 Protein (Myc-DYKDDDDK Tag)

Catalog No. ABIN2720123

Product Details

Target: ELAVL1 (ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 1 (Hu Antigen R) (ELAVL1))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This ELAVL1 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human ELAVL1 / HUR protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

References

Gorbatenko, Olesen, Loebl, Sigurdsson, Bianchi, Pedraz-Cuesta, Christiansen, Pedersen: "Oncogenic p95HER2 regulates Na+-HCO3- cotransporter NBCn1 mRNA stability in breast cancer cells via 3'UTR-dependent processes." in: The Biochemical journal, Vol. 473, Issue 21, pp. 4027-4044, (2016) (PubMed).

Choudhury, de Lima Alves, de Andrés-Aguayo, Graf, Cáceres, Rappsilber, Michlewski: "Tissue-specific control of brain-enriched miR-7 biogenesis." in: Genes & development, Vol. 27, Issue 1, pp. 24-38, (2013) (PubMed).

Target Details

Target: ELAVL1 (ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 1 (Hu Antigen R) (ELAVL1))

Alternative Name: Elavl1,hur (ELAVL1 Products)

Synonyms: ELAV1 Protein, HUR Protein, Hua Protein, MelG Protein, HuR Protein, 2410055N02Rik Protein, W91709 Protein, elra Protein, fa25f08 Protein, fb59a02 Protein, fc60g02 Protein, hua Protein, wu:fa25f08 Protein, wu:fb59a02 Protein, wu:fc60g02 Protein, zHuA Protein, Elavl1 Protein, Xel-1 Protein, elav1 Protein, elrA Protein, hur Protein, melg Protein, p36 Protein, ElrA Protein, elavl1 Protein, elavl1-a Protein, elavl1-b Protein, ELAV like RNA binding protein 1 Protein, ELAV-like protein 1 Protein, ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R) Protein, ELAV like RNA binding protein 1a Protein, ELAV like RNA binding protein 1 L homeolog Protein, ELAV like RNA binding protein 1 S homeolog Protein, ELAVL1 Protein, Elavl1 Protein, elav1 Protein, elavl1a Protein, elavl1.L Protein, elavl1.S Protein

Background: The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy.

Molecular Weight: 35.9 kDa

NCBI Accession: NP_001410

Pathways: AMPK Signaling