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Browse our anti-PRKAA1 (PRKAA1) Antibodies

Full name:
anti-Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit Antibodies (PRKAA1)
On www.antibodies-online.com are 308 Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) Antibodies from 28 different suppliers available. Additionally we are shipping PRKAA1 Kits (21) and PRKAA1 Proteins (6) and many more products for this protein. A total of 344 PRKAA1 products are currently listed.
Synonyms:
AI194361, AI450832, AL024255, AMPK, AMPK1, AMPKa1, AMPKalpha1, C130083N04Rik, cb116, im:7154392, PRKAA1, sb:cb130, wu:fa94c10
list all antibodies Gene Name GeneID UniProt
PRKAA1 108080  
PRKAA1 5562 Q13131
PRKAA1 65248 P54645

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Top referenced anti-PRKAA1 Antibodies

  1. Cow (Bovine) Polyclonal PRKAA1 Primary Antibody for ICC, IF - ABIN151706 : Zang, Zuccollo, Hou, Nagata, Walsh, Herscovitz, Brecher, Ruderman, Cohen: AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells. in The Journal of biological chemistry 2004 (PubMed)
    Show all 12 references for ABIN151706

  2. Human Monoclonal PRKAA1 Primary Antibody for IF, WB - ABIN393792 : Jassim, Fernø, Theisen, Haberhausen, Christoforou, Håvik, Gebhardt, Remschmidt, Mehler-Wex, Hebebrand, Lehellard, Steen: Association study of energy homeostasis genes and antipsychotic-induced weight gain in patients with schizophrenia. in Pharmacopsychiatry 2011 (PubMed)
    Show all 5 references for ABIN393792

  3. Human Polyclonal PRKAA1 Primary Antibody for IHC (p), WB - ABIN359481 : Pang, Xiong, Li, Qiu, Jin, Shen, Li: Conserved alpha-helix acts as autoinhibitory sequence in AMP-activated protein kinase alpha subunits. in The Journal of biological chemistry 2007 (PubMed)
    Show all 3 references for ABIN359481

  4. Human Polyclonal PRKAA1 Primary Antibody for EIA, WB - ABIN359393 : Zhang, Ye, Wu, Ren, Zhao, Zhao, Fu, Shen, Fan, Lu, Zhong, Xu, Han, Zhang, Tao, Huang, Zhou, Hu, Gu, Chen, Chen: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. in Genome research 2000 (PubMed)
    Show all 2 references for ABIN359393

  5. Human Polyclonal PRKAA1 Primary Antibody for IF, IHC (p) - ABIN196904 : Kim, Tannenbaum, White: Global phosphoproteome of HT-29 human colon adenocarcinoma cells. in Journal of proteome research 2005 (PubMed)
    Show all 2 references for ABIN196904

  6. Human Monoclonal PRKAA1 Primary Antibody for ELISA, FACS - ABIN4280435 : Xiao, Kwong, Daemen, Belvin, Liang, Hatzivassiliou, OBrien: Metabolic Response to NAD Depletion across Cell Lines Is Highly Variable. in PLoS ONE 2016 (PubMed)

  7. Human Polyclonal PRKAA1 Primary Antibody for WB - ABIN2785614 : Hasumi, Baba, Hong, Hasumi, Huang, Yao, Valera, Linehan, Schmidt: Identification and characterization of a novel folliculin-interacting protein FNIP2. in Gene 2008 (PubMed)

  8. Human Polyclonal PRKAA1 Primary Antibody for FACS, IHC (p) - ABIN652306 : Puissant, Robert, Fenouille, Luciano, Cassuto, Raynaud, Auberger: Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation. in Cancer research 2010 (PubMed)

More Antibodies against PRKAA1 Interaction Partners

Mouse (Murine) Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. AMPK activation stimulates oxidant-induced stress granule formation but limits their fusion into larger granules.

  2. AMPKalpha1 deficiency in vascular smooth muscle cells promoted atherosclerotic calcification.

  3. this study shows that inhibition of experimental autoimmune encephalomyelitis is associated with activation of AMPK/SIRT1 (show SIRT1 Antibodies) signaling pathway

  4. this study shows that stearoyl lysophosphatidylcholine increases macrophages phagocytosis of bacteria through activation of the AMPK/p38 MAPK (show MAPK14 Antibodies) pathway

  5. this study shows that Le Carbone, a charcoal supplement, attenuates experimental colitis through activation of AMPKalpha (show GRK4 Antibodies)

  6. Data show that metformin may protect against ciaplatin induced acute kidney injury (AKI) through stimulating AMPKalpha (show GRK4 Antibodies) activation.

  7. m(6)A methylation status influences RNA, AMPKalpha1 phosphorylation and dysfunctional adipose tissue induced by high-fat diet

  8. phosphorylation of PLIN2 (show PLIN2 Antibodies) is dependent on AMPK and occurs after the interaction of PLIN2 (show PLIN2 Antibodies) with the chaperone-mediated autophagy chaperone HSPA8/Hsc70 (show HSPA8 Antibodies).

  9. Ngb (show NGB Antibodies) functions as a metabolic regulator and enhances cellular anabolism through the inhibition of AMPK signaling.

  10. findings indicate that miR (show MLXIP Antibodies)-291b-3p promotes hepatic lipogenesis by suppressing AMPKalpha1 expression and activity, indicating the therapeutic potential of miR (show MLXIP Antibodies)-291b-3p inhibitors in fatty liver disease.

Cow (Bovine) Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. Endometrial inflammatory responses to lipopolysaccharide were also reduced by small molecules that activate or inhibit the intracellular sensor of energy, AMP-activated protein kinase (AMPK (show PRKAA2 Antibodies)).

  2. The results suggest that activation of AMPK represses global protein synthesis in mammary epithelial cells through inhibition of mTORC1 signaling.

  3. Nitrated oleic acid activates AMPK in endothelial cells.

  4. Findings suggest that ischemic factor stimulation of the blood brain barrier Na-K-Cl cotransporter (show SLC12A1 Antibodies) involves activation of AMPK.

  5. Results suggest that mitochondria-derived superoxide anions and peroxynitrite are required for Berberine-induced AMPK activation in endothelial cells.

  6. the expression, but not the kinase activity, of AMPK and CaMKKbeta is necessary for ADP signaling to eNOS (show NOS3 Antibodies)

Human Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. AMPK activation stimulates oxidant-induced stress granule formation but limits their fusion into larger granules.

  2. ENO1 (show ENO1 Antibodies) is a potent promoter of colorectal cancer genesis and metastasis at least in part though regulating AMPK/mTOR (show FRAP1 Antibodies) pathway.

  3. We functionally validated several elements for metformin-induced promoter and enhancer activity. These include an enhancer in an ataxia telangiectasia mutated (ATM (show ATM Antibodies)) intron that has SNPs in linkage disequilibrium .Using ChIP-seq and siRNA knockdown, we further show that activating transcription factor 3 (ATF3 (show ATF3 Antibodies)), our top metformin upregulated AMPK-dependent gene, could have an important role in gluconeogenesis repression.

  4. In vivo, AICAR (show ATIC Antibodies) significantly reduced osteosarcoma growth without apparent body weight loss and AICAR (show ATIC Antibodies) increased both mitochondrial proliferation and apoptotic activity in treated tumor tissues. AICAR (show ATIC Antibodies) showed anticancer effects in osteosarcoma cells through an AMPK-dependent peroxisome proliferatoractivated receptor-gamma coactivator-1alpha (PGC-1alpha (show PPARGC1A Antibodies))/mitochondrial transcription factor A (TFAM (show TFAM Antibodies))/mitochondrial pathway

  5. Our results indicated that ETS1 (show ETS1 Antibodies) induced autophagy after inhibition of glycolysis, and thus led to comparative decrease of cell viability. These results implied that ETS1 (show ETS1 Antibodies) could be a potential target for tumor metabolic therapy.

  6. These results may provide one explanation for the low activity of EGFR (show EGFR Antibodies) inhibitors in clinical trials and suggest antagonism of AMPK or of AMPK-regulated metabolic alterations as a promising approach to enhance their therapeutic efficacy.

  7. AMPK exerts multiple actions on TGF-beta (show TGFB1 Antibodies) signaling and supports that AMPK can serve as a therapeutic drug target for breast cancer

  8. Despite differences in total work done, low-volume INT and CON (show DISP1 Antibodies) 'all-out' cycling, matched for exercise duration, provides a similar stimulus for the induction of mitochondrial and angiogenic cell signalling pathways in trained skeletal muscle.

  9. Suggest that fenoterol inhibited AICAR (show ATIC Antibodies)-induced AMPK alpha1 activation and TNF-alpha (show TNF Antibodies) release through beta-arrestin-2 (show ARRB2 Antibodies) in THP-1 (show GLI2 Antibodies) cells.

  10. Down-regulation of miR (show MLXIP Antibodies)-137 ameliorates high glucose-induced injury in HUVEC cells by overexpression of AMPKa1, leading to increasing cellular reductive reactions and decreasing oxidative stress.

Zebrafish Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. AMPK-related pathways may be compromised during fluoxetine exposure as a result of increased miRNA abundance.

Xenopus laevis Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. Constitutively active AMPKgammaR70Q significantly decreases Napi-IIa (show SLC34A1 Antibodies) oocyte cell membrane abundance, an effect not mimicked by catalytically-inactive AMPKalphaK45R.

  2. NDPK-A (show NME1 Antibodies) exists in a functional cellular complex with AMPK (show PRKAA2 Antibodies) and CFTR (show CFTR Antibodies) in airway epithelia, and NDPK-A (show NME1 Antibodies) catalytic function is required for the AMPK (show PRKAA2 Antibodies)-dependent regulation of CFTR (show CFTR Antibodies)

Pig (Porcine) Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) interaction partners

  1. AMPK-mTOR (show FRAP1 Antibodies)-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.

  2. Data indicate that 17beta-estradiol reduced Sertoli Cell proliferation by inhibiting microRNA miR (show MYLIP Antibodies)-1285 and thus activating AMP-activated protein kinase (AMPK (show PRKAA2 Antibodies)).

  3. L-Glutamine (show GFPT2 Antibodies) enhances enterocyte growth but did not affect abundances of total or phosphorylated AMPK protein.

  4. AMPK activity plays an important role in the maintenance of the spermatozoa quality during long-term storage of boar semen.

  5. AMPK, lying downstream of PKA, regulates at different levels mammalian spermatozoa membrane function.

  6. Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK/ERK (show MAPK1 Antibodies)/TSC2 (show TSC2 Antibodies)/mTOR (show FRAP1 Antibodies) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis

  7. AMPK deficiency or inhibition attenuated or mitigated ethanol exposure-triggered glucose intolerance and compromised cardiac contraction by increased phosphorylation of AMPK and acetyl-CoA carboxylase as well as autophagosome accumulation.

  8. AMPK functions to inhibit IGF-I (show IGF1 Antibodies)-stimulated PI3K pathway activation through stimulation of IRS-1 (show IRS1 Antibodies) serine 794 phosphorylation.

  9. acute activation of AMPK increases intestinal glucose absorption after administration of long-chain n-3 polyunsaturated fatty acids during gestation

PRKAA1 Antigen Profile

Antigen Summary

The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Alternative names and synonyms associated with PRKAA1

  • protein kinase, AMP-activated, alpha 3 catalytic subunit (Prkaa3) antibody
  • protein kinase, AMP-activated, alpha 1 catalytic subunit (PRKAA1) antibody
  • protein kinase, AMP-activated, alpha 1 catalytic subunit (prkaa1) antibody
  • protein kinase, AMP-activated, alpha 1 catalytic subunit (Prkaa1) antibody
  • AI194361 antibody
  • AI450832 antibody
  • AL024255 antibody
  • AMPK antibody
  • AMPK1 antibody
  • AMPKa1 antibody
  • AMPKalpha1 antibody
  • C130083N04Rik antibody
  • cb116 antibody
  • im:7154392 antibody
  • PRKAA1 antibody
  • sb:cb130 antibody
  • wu:fa94c10 antibody

Protein level used designations for PRKAA1

protein kinase, AMP-activated, alpha 3 catalytic subunit , protein kinase, AMP-activated, alpha 1 catalytic subunit , 5'-AMP-activated protein kinase catalyti subunit alpha-1-like protein , 5'-AMP-activated protein kinase catalytic subunit alpha-1 , AMPK-activated protein kinase alpha-1 subunit , 5'-AMP-activated protein kinase alpha 1 catalytic subunit , 5'-AMP-activated protein kinase, catalytic alpha-1 chain , ACACA kinase , AMP -activate kinase alpha 1 subunit , AMP-activated protein kinase, catalytic, alpha-1 , AMPK alpha 1 , AMPK subunit alpha-1 , HMGCR kinase , acetyl-CoA carboxylase kinase , hydroxymethylglutaryl-CoA reductase kinase , tau-protein kinase PRKAA1 , AMPK alpha-1 chain , AMP-activated protein kinase, alpha 1 catalytic subunit , ampka1 , 5'-AMP-activated protein kinase alpha-1 catalytic subunit , AMPKalpha1 , 63 kDa subunit , AMPK 63 kDa subunit

GENE ID SPECIES
108080 Mus musculus
100009710 Equus caballus
100034740 Meleagris gallopavo
100145520 Xenopus (Silurana) tropicalis
100294665 Ovis aries
540404 Bos taurus
5562 Homo sapiens
65248 Rattus norvegicus
105787 Mus musculus
100001198 Danio rerio
495290 Xenopus laevis
427185 Gallus gallus
479351 Canis lupus familiaris
100145903 Sus scrofa
100174304 Pongo abelii
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