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Browse our SREBF1 Proteins (SREBF1)

Full name:
Sterol Regulatory Element Binding Transcription Factor 1 Proteins (SREBF1)
On are 10 Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) Proteins from 3 different suppliers available. Additionally we are shipping SREBF1 Antibodies (149) and SREBF1 Kits (21) and many more products for this protein. A total of 195 SREBF1 products are currently listed.
ADD-1, ADD1, bHLHd1, D630008H06, SCREBP1, SREBF1, SREBP-1, SREBP-1a, SREBP-1C, Srebp1, SREBP1c
list all proteins Gene Name GeneID UniProt
SREBF1 6720 P36956
SREBF1 20787 Q9WTN3
SREBF1 78968 P56720

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SREBF1 Proteins (SREBF1) by Origin

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More Proteins for SREBF1 Interaction Partners

Pig (Porcine) Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) interaction partners

  1. dysregulation of SIRT1 (show SIRT1 Proteins)-AMPK (show PRKAA1 Proteins)-SREBP and stimulation of NLRP3 (show NLRP3 Proteins) inflammasome may contribute to vascular lipid deposition and inflammation in atherosclerosis

  2. Polymorphisms of the ACACA and SREBF1 genes are promising markers for pig carcass and performance traits.

  3. IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.

  4. Basal transcription and supra-additive stimulation of porcine LDLR gene transcription by LH and insulin in granulosa-luteal cells require SREBP-1a and Sp1/Sp3-binding elements.

  5. Results of associated analysis show that the polymorphism of ADD1 gene was associated traits of Intramuscular fat content (IMF (show MDFI Proteins)) and back fat thickness (BF).

  6. SREBF1 might play an important role in regulation of muscle fat deposition during postnatal growth of pigs.

Cow (Bovine) Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) interaction partners

  1. Hepatic SREBP-1c-mediated lipid synthesis and the NF-kappaB (show NFKB1 Proteins) inflammatory pathway were both overinduced in cows with fatty liver.

  2. SREBP1 was found to be a key positive regulator of milk fat synthesis and was shown to be regulated by stearic acid and serum.

  3. data suggest that low SREBP-1c expression can decrease lipid synthesis, increase lipid oxidation, and decrease the TG and VLDL content in bovine hepatocytes

  4. 84-bp indel in intron 5 was significantly associated with palmitoleic acid, stearic acid, saturated fatty acids, triglycerides and the C16 index in Simmental bulls.

  5. genetic polymorphisms in sterol regulatory element binding transcription factor 1 (SREBF1)can be used to develop genetic tools for the selection of animals producing milk with healthier fatty acid composition

  6. The results of this study demonstrated the existence of the polymorphisms in the SCD1 (show SCD Proteins) and SREBP-1 genes in the population of Fleckvieh cattle and their associations with the concentrations of several muscle fat and subscutaneous fat fatty acids.

  7. These results provide detailed genetic information for the SREBP1 signalling pathway and SCD (show SCD Proteins) that can be used to change milk fat composition by marker-assisted breeding.

  8. The SREBP1-9 SNP showed a significant effect on marbling score, monounsaturated fatty acids and C18 (show BBS9 Proteins):1n-9 in the muscle fat of commercial Korean cattle.

  9. An association was found between five single sequence variants and 38 possible SREBP-1c combined genotypes with growth traits in cattle.

  10. These results suggest that the indel mutation of bovine ADD1/SREBP1c gene may influence the growth traits in cattle.[SREBP1c]

Caenorhabditis elegans (C. elegans) Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) interaction partners

  1. the ability of Pu-erh (show ERH Proteins) tea in promoting inhibition of food uptake and the biosynthesis of fat via SBP-1 and SCD (show SCD Proteins), thereby reducing fat storage.

  2. SBP-1/SREBP-1 is part of a conserved feedback loop responding to phosphatidylcholine (show SGMS1 Proteins) levels to regulate expression of one-carbon cycle biogenesis genes and ensure adequate S-adenosylmethionine levels for phosphatidylcholine (show SGMS1 Proteins) production.

  3. elo-5 and elo-6 may be transcriptional targets of LPD (show ACSBG1 Proteins)-1

  4. both SBP-1 and MDT-15 control transcription of genes governing desaturation of stearic acid to oleic acid

  5. Essential role of sbp-1 activation in oxygen deprivation induced lipid accumulation and increase in body width/length ratio in Caenorhabditis elegans.

Human Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) interaction partners

  1. Data show that mutant p53 protein (show TP53 Proteins) activates the sterol regulatory element-binding proteins SREBP-1 and SREBP-2 (show SREBF2 Proteins)-mediated signaling pathways in prostate cancer (PCa (show FLVCR1 Proteins)) cells.

  2. miR (show MLXIP Proteins)-33b is highly induced upon differentiation of human preadipocytes, along with SREBP-1 and miR (show MLXIP Proteins)-33b is an important regulator of adipogenesis

  3. Akt1 (show AKT1 Proteins) and Akt2 (show AKT2 Proteins) activated both SREBP-1 and SREBP-2 (show SREBF2 Proteins), whereas Akt3 (show AKT3 Proteins) upregulated SREBP-1 to enhance hepatitis C virus translation.

  4. PRMT5-induced methylation prevented phosphorylation of SREBP1a on S430 by GSK3beta

  5. mTORC2 (show CRTC2 Proteins) positively regulates mSREBP1 stability and lipogenesis. Findings reveal a novel biological function of mTORC2 (show CRTC2 Proteins) in the regulation of lipogenesis

  6. Data suggest that Hepacivirus (HCV) activates hepatocyte NLRP3 (show NLRP3 Proteins) inflammasomes, induces lipogenic enzymes/lipid droplet formation, and up-regulates transport of SREBF1/SREBF2 (show SREBF2 Proteins)/SCAP (show SH2D2A Proteins) from ER to Golgi where SREBPs undergo proteolytic activation by S1P (show MBTPS1 Proteins)/S2P (show MBTPS2 Proteins).

  7. hnRNP A1 (show HNRNPA1 Proteins) is implicated in the free fatty acid-induced expression of SREBP-1a and of its target genes as well as in the lipid accumulation in hepatocytes.

  8. TG levels are regulated by HCBP6-sterol regulatory element binding protein (show CNBP Proteins) 1c (SREBP1c)-mediated fatty acid synthase (FASN (show FASN Proteins)) expression.

  9. Aberrant activation of SREBP1c suppresses primary ciliogenesis by PLA2G3 (show PLA2G3 Proteins)-mediated distortion of vesicular trafficking and suggest that PLA2G3 (show PLA2G3 Proteins) is a novel potential target to normalize ciliogenesis in SREBP1c-overexpressing cells, including cancer cells.

  10. PD-L1 (show CD274 Proteins) induces epithelial-to-mesenchymal transition via activating SREBP-1c in renal cell carcinoma (show MOK Proteins).

Mouse (Murine) Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) interaction partners

  1. The two cereal dietary fibers potently decreased protein expressions of sterol regulatory element binding protein-1 and key factors involved in lipogenesis

  2. SREBP-1 acts as a positive regulator of Sfrp2 (show SFRP2 Proteins) transcription in chondrogenic cells.

  3. regulatory mechanism by which insulin (show INS Proteins) inhibits cardiac UCP3 expression through activation of the lipogenic factor SREBP-1.

  4. Taken together, our results suggest that an NCE-box within the clusterin (show CLU Proteins) promoter is necessary for insulin (show INS Proteins)-stimulated hepatic expression of clusterin (show CLU Proteins) via SREBP-1c.

  5. both Smad3 (show SMAD3 Proteins) and SREBP-1a activation cooperatively regulate TGFbeta (show TGFB1 Proteins) transcriptional responses.

  6. Endoplasmic reticulum stress and SREBP-1-dependent effects were induced in glomeruli of angiotensin II-infused mice.

  7. Data show that knock-in (KI) mice in which a human miR (show MLXIP Proteins)-33b is inserted within sterol regulatory element-binding protein 1 (Srebf1) intron had reduced HDL (show HSD11B1 Proteins) cholesterol (HDL (show HSD11B1 Proteins)-C).

  8. CREB regulated transcription coactivator 2 (CRTC2 (show CRTC2 Proteins)) functions as a mediator of mTOR (show FRAP1 Proteins) signalling to modulate COPII-dependent SREBP1 processing

  9. Thyrotropin increases hepatic triglyceride content through upregulation of SREBP-1c activity.

  10. Hepatic genes expression profiles demonstrated that LBP (show LBP Proteins) can activate the phosphorylation of AMPK (show PRKAA1 Proteins), suppress nuclear expression of SREBP-1c, and decrease protein and mRNA expression of lipogenic genes in vivo or in vitro

SREBF1 Protein Profile

Protein Summary

This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with SREBF1

  • sterol regulatory element binding transcription factor 1 (SREBF1)
  • sterol regulatory element binding transcription factor 1 (srebf1)
  • similar to sterol regulatory element binding transcription factor 1 isoform b (SREBF1)
  • sterol regulatory element binding protein 1 (SREBP-1)
  • sterol regulatory element binding protein-1 (SREBP-1)
  • Sterol regulatory element Binding Protein (sbp-1)
  • sterol regulatory element binding transcription factor 1 (Srebf1)
  • ADD-1 protein
  • ADD1 protein
  • bHLHd1 protein
  • D630008H06 protein
  • SCREBP1 protein
  • SREBF1 protein
  • SREBP-1 protein
  • SREBP-1a protein
  • SREBP-1C protein
  • Srebp1 protein
  • SREBP1c protein

Protein level used designations for SREBF1

sterol regulatory element binding protein 1 , sterol regulatory element-binding protein 1 , sterol regulatory element binding-protein 1 , sterol regulatory element binding transcription factor 1 , similar to sterol regulatory element binding transcription factor 1 isoform b , sterol regulatory element binding protein-1 , SREBP1 , sterol regulatory element-binding protein 1-like , Sterol regulatory element Binding Protein family member (sbp-1) , SREBP-1 , class D basic helix-loop-helix protein 1 , adipocyte determination and differentiation-dependent factor 1 , sterol regulatory binding transcription factor 1 , sterol regulatory element-binding transcription factor 1 , sterol response element binding protein 1 , adipocyte determination- and differentiation-dependent factor 1 , Sterol regulatory element-binding transcription factor 1

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454480 Pan troglodytes
494844 Xenopus laevis
706972 Macaca mulatta
100329218 Ovis aries
396572 Sus scrofa
100008784 Oryctolagus cuniculus
100529250 Bos taurus
793274 Danio rerio
100029730 Monodelphis domestica
100052283 Equus caballus
100405845 Callithrix jacchus
100438806 Pongo abelii
100502556 Salmo salar
100591724 Nomascus leucogenys
176574 Caenorhabditis elegans
6720 Homo sapiens
397308 Sus scrofa
539361 Bos taurus
20787 Mus musculus
78968 Rattus norvegicus
100689018 Cricetulus griseus
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