Browse our SREBF1 Proteins (SREBF1)

Full name:
Sterol Regulatory Element Binding Transcription Factor 1 Proteins (SREBF1)
On www.antibodies-online.com are 11 Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) Proteins from 4 different suppliers available. Additionally we are shipping SREBF1 Antibodies (166) and SREBF1 Kits (13) and many more products for this protein. A total of 205 SREBF1 products are currently listed.
Synonyms:
ADD-1, ADD1, bHLHd1, D630008H06, SCREBP1, SREBF1, SREBP-1, SREBP-1a, SREBP-1C, Srebp1, SREBP1c
list all proteins Gene Name GeneID UniProt
SREBF1 6720 P36956
SREBF1 20787 Q9WTN3
SREBF1 78968 P56720

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SREBF1 Proteins (SREBF1) by Origin

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More Proteins for SREBF1 Interaction Partners

Pig (Porcine) Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) interaction partners

  1. dysregulation of SIRT1 (show SIRT1 Proteins)-AMPK (show PRKAA1 Proteins)-SREBP and stimulation of NLRP3 (show NLRP3 Proteins) inflammasome may contribute to vascular lipid deposition and inflammation in atherosclerosis

  2. Polymorphisms of the ACACA and SREBF1 genes are promising markers for pig carcass and performance traits.

  3. IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.

  4. Basal transcription and supra-additive stimulation of porcine LDLR gene transcription by LH and insulin in granulosa-luteal cells require SREBP-1a and Sp1/Sp3-binding elements.

  5. Results of associated analysis show that the polymorphism of ADD1 gene was associated traits of Intramuscular fat content (IMF (show MDFI Proteins)) and back fat thickness (BF).

  6. SREBF1 might play an important role in regulation of muscle fat deposition during postnatal growth of pigs.

Cow (Bovine) Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) interaction partners

  1. SREBP1a activated while C/EBP (show CEBPA Proteins) factors downregulated the activity of the SCD1 (show SCD Proteins) promoter.

  2. These results suggest that increased expression of hepatic CD36 (show CD36 Proteins) and SREBP-1 is relevant in the obesity-driven lipid accumulation in the liver of dairy cows during late gestation.

  3. Hepatic SREBP-1c-mediated lipid synthesis and the NF-kappaB (show NFKB1 Proteins) inflammatory pathway were both overinduced in cows with fatty liver.

  4. SREBP1 was found to be a key positive regulator of milk fat synthesis and was shown to be regulated by stearic acid and serum.

  5. data suggest that low SREBP-1c expression can decrease lipid synthesis, increase lipid oxidation, and decrease the TG and VLDL content in bovine hepatocytes

  6. 84-bp indel in intron 5 was significantly associated with palmitoleic acid, stearic acid, saturated fatty acids, triglycerides and the C16 index in Simmental bulls.

  7. genetic polymorphisms in sterol regulatory element binding transcription factor 1 (SREBF1)can be used to develop genetic tools for the selection of animals producing milk with healthier fatty acid composition

  8. The results of this study demonstrated the existence of the polymorphisms in the SCD1 (show SCD Proteins) and SREBP-1 genes in the population of Fleckvieh cattle and their associations with the concentrations of several muscle fat and subscutaneous fat fatty acids.

  9. These results provide detailed genetic information for the SREBP1 signalling pathway and SCD (show SCD Proteins) that can be used to change milk fat composition by marker-assisted breeding.

  10. The SREBP1-9 SNP showed a significant effect on marbling score, monounsaturated fatty acids and C18 (show BBS9 Proteins):1n-9 in the muscle fat of commercial Korean cattle.

Caenorhabditis elegans (C. elegans) Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) interaction partners

  1. the ability of Pu-erh (show ERH Proteins) tea in promoting inhibition of food uptake and the biosynthesis of fat via SBP-1 and SCD (show SCD Proteins), thereby reducing fat storage.

  2. SBP-1/SREBP-1 is part of a conserved feedback loop responding to phosphatidylcholine (show SGMS1 Proteins) levels to regulate expression of one-carbon cycle biogenesis genes and ensure adequate S-adenosylmethionine levels for phosphatidylcholine (show SGMS1 Proteins) production.

  3. elo-5 and elo-6 may be transcriptional targets of LPD (show ACSBG1 Proteins)-1

  4. both SBP-1 and MDT-15 control transcription of genes governing desaturation of stearic acid to oleic acid

  5. Essential role of sbp-1 activation in oxygen deprivation induced lipid accumulation and increase in body width/length ratio in Caenorhabditis elegans.

Human Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) interaction partners

  1. Glucose adsorption to chitosan membranes increases proliferation of human chondrocytes via mammalian target of rapamycin (show FRAP1 Proteins) complex 1 and sterol regulatory element-binding protein-1 signaling.

  2. miR (show MLXIP Proteins)-185 negatively regulates the differentiation of 3T3-L1 cells by targeting SREBP-1

  3. The authors further demonstrated that the upregulation of sterol regulatory element-binding protein (show CNBP Proteins) (SREBP)-1c by activation of the Akt (show AKT1 Proteins) and p70S6K (show RPS6KB1 Proteins) pathways is critical for high-glucose-treated Porphyromonas gingivalis-induced NLRP3 (show NLRP3 Proteins) expression.

  4. Results show that PPARalpha (show PPARA Proteins) is downregulated and SREBP-1c is upregulated in steatosis L-02 cells. These changes increase lipid synthesis and reduce lipid disposal, which ultimately lead to hepatic steatosis.

  5. SREBP-1 and SREBP-2 mRNA expression levels were measured in EAT from 49 patients with CAD (26 with diabetes) and 23 controls without CAD or diabetes.SREBP expression was associated as cardiovascular risk factor for the severity of CAD and the poor lipid control.

  6. The involvement of SREBP-1c in FASN (show FASN Proteins) promoter histone modification.

  7. the mitotic phosphorylation and stabilization of nuclear SREBP1 during cell division provides a link between lipid metabolism and cell proliferation.

  8. B7-H3 (show CD276 Proteins) hijacks SREBP-1/FASN (show FASN Proteins) signaling mediating abnormal lipid metabolism in lung cancer

  9. The genetic polymorphisms of SREBF1 could play a role in the mechanism for interindividual variation of atypical antipsychotics-induced metabolic syndrome (MetS). SCAP polymorphisms with drug-induced MetS were negative in this study.

  10. NS5ATP6 regulates the intracellular triglyceride level via FGF21 (show FGF21 Proteins), and independently of SIRT1 (show SIRT1 Proteins) and SREBP1.

Mouse (Murine) Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) interaction partners

  1. suggesting a specific effect of sterol regulatory element binding protein (show CNBP Proteins)-1c on neurosteroidogenesis

  2. Transforming growth factor-beta activated kinase 1 (TAK1 (show MAP3K7 Proteins)) regulation of sterol-regulatory element-binding proteins (SREBPs) critically contributes to the maintenance of liver homeostasis to prevent steatosis, which is a potentially important mechanism to prevent hepatocellular carcinoma (HCC (show FAM126A Proteins)) development.

  3. miR (show MLXIP Proteins)-185 negatively regulates the differentiation of 3T3-L1 cells by targeting SREBP-1

  4. SREBP1 pathway plays an important role in hepatocellular carcinoma pathogenesis.

  5. In hepatocytes, E4BP4 (show NFIL3 Proteins) interacts with nuclear SREBP-1c to preserve its acetylation, and subsequently protects it from ubiquitination-dependent degradation

  6. SREBP1 also contributes to the resolution phase of TLR4 (show TLR4 Proteins)-induced gene activation by reprogramming macrophage lipid metabolism.

  7. 27OH is not an important regulator of Srebp- or LXR regulated genes under basal conditions in mouse liver

  8. Collectively, these findings demonstrate that LXRalpha (show NR1H3 Proteins) activation induces 17beta-HSD13 expression in a SREBP-1c-dependent manner.

  9. These results demonstrate that HDAC3 and SCAP control symbiotic pathways of liver lipid metabolism that are critical for suppression of lipotoxicity.

  10. data indicate that ATF4 (show ATF4 Proteins) regulates SREBP1c expression to control fatty acids synthesis

SREBF1 Protein Profile

Protein Summary

This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with SREBF1

  • sterol regulatory element binding transcription factor 1 (SREBF1)
  • sterol regulatory element binding transcription factor 1 (srebf1)
  • similar to sterol regulatory element binding transcription factor 1 isoform b (SREBF1)
  • sterol regulatory element binding protein 1 (SREBP-1)
  • sterol regulatory element binding protein-1 (SREBP-1)
  • Sterol regulatory element Binding Protein (sbp-1)
  • sterol regulatory element binding transcription factor 1 (Srebf1)
  • ADD-1 protein
  • ADD1 protein
  • bHLHd1 protein
  • D630008H06 protein
  • SCREBP1 protein
  • SREBF1 protein
  • SREBP-1 protein
  • SREBP-1a protein
  • SREBP-1C protein
  • Srebp1 protein
  • SREBP1c protein

Protein level used designations for SREBF1

sterol regulatory element binding protein 1 , sterol regulatory element-binding protein 1 , sterol regulatory element binding-protein 1 , sterol regulatory element binding transcription factor 1 , similar to sterol regulatory element binding transcription factor 1 isoform b , sterol regulatory element binding protein-1 , SREBP1 , sterol regulatory element-binding protein 1-like , Sterol regulatory element Binding Protein family member (sbp-1) , SREBP-1 , class D basic helix-loop-helix protein 1 , adipocyte determination and differentiation-dependent factor 1 , sterol regulatory binding transcription factor 1 , sterol regulatory element-binding transcription factor 1 , sterol response element binding protein 1 , adipocyte determination- and differentiation-dependent factor 1 , Sterol regulatory element-binding transcription factor 1

GENE ID SPECIES
373915 Gallus gallus
403475 Canis lupus familiaris
454480 Pan troglodytes
494844 Xenopus laevis
706972 Macaca mulatta
100329218 Ovis aries
396572 Sus scrofa
100008784 Oryctolagus cuniculus
100529250 Bos taurus
793274 Danio rerio
100029730 Monodelphis domestica
100052283 Equus caballus
100405845 Callithrix jacchus
100438806 Pongo abelii
100502556 Salmo salar
100591724 Nomascus leucogenys
176574 Caenorhabditis elegans
6720 Homo sapiens
397308 Sus scrofa
539361 Bos taurus
20787 Mus musculus
78968 Rattus norvegicus
100689018 Cricetulus griseus
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