Browse our anti-STRADA (STRADA) Antibodies

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anti-STE20-Related Kinase Adaptor alpha Antibodies (STRADA)
On are 95 STE20-Related Kinase Adaptor alpha (STRADA) Antibodies from 15 different suppliers available. Additionally we are shipping STRADA Proteins (12) and many more products for this protein. A total of 116 STRADA products are currently listed.
2610019A05Rik, 6030402H20Rik, AI480680, E130112C09Rik, fj99g05, Lyk5, NY-BR-96, PMSE, Stlk, STRAD, wu:fj99g05, zgc:56109
list all antibodies Gene Name GeneID UniProt
STRADA 303605 Q7TNZ6

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anti-Human STRADA Antibodies:

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anti-Mouse (Murine) STRADA Antibodies:

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Top referenced anti-STRADA Antibodies

  1. Human Polyclonal STRADA Primary Antibody for WB - ABIN4331949 : Yoneda, Guo, Ono, Nakatsu, Zhang, Cui, Iwashita, Kumamoto, Tsuchiya, Sakoda, Fujishiro, Kushiyama, Koketsu, Kikuchi, Kamata, Nishimura, Asano: Decreased SIRT1 expression and LKB1 phosphorylation occur with long-term high-fat diet feeding, in addition to AMPK phosphorylation impairment in the early phase. in Obesity research & clinical practice 2013 (PubMed)

  2. Human Polyclonal STRADA Primary Antibody for WB - ABIN1981302 : Sun, Li, Chen, Huang, Chen, Cui, Liu, Thrasher, Li: GSK-3? controls autophagy by modulating LKB1-AMPK pathway in prostate cancer cells. in The Prostate 2015 (PubMed)

  3. Cow (Bovine) Polyclonal STRADA Primary Antibody for WB - ABIN2783633 : Marignani, Scott, Bagnulo, Cannone, Ferrari, Stella, Guanti, Simone, Resta: Novel splice isoforms of STRADalpha differentially affect LKB1 activity, complex assembly and subcellular localization. in Cancer biology & therapy 2008 (PubMed)

  4. Human Polyclonal STRADA Primary Antibody for EIA, WB - ABIN492731 : Zeqiraj, Filippi, Goldie, Navratilova, Boudeau, Deak, Alessi, van Aalten: ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor. in PLoS biology 2009 (PubMed)

  5. Human Polyclonal STRADA Primary Antibody for EIA, WB - ABIN359296 : Baas, Boudeau, Sapkota, Smit, Medema, Morrice, Alessi, Clevers: Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD. in The EMBO journal 2003 (PubMed)

More Antibodies against STRADA Interaction Partners

Rabbit STE20-Related Kinase Adaptor alpha (STRADA) interaction partners

  1. SPAK (show STK39 Antibodies) is a powerful regulator of peptide transporters PEPT1 (show SLC15A1 Antibodies) and PEPT2 (show SLC15A2 Antibodies)

Human STE20-Related Kinase Adaptor alpha (STRADA) interaction partners

  1. aberrant nuclear accumulation of LKB1 (show STK11 Antibodies) caused by STRADalpha deficiency contributes to hyperactivation of mTORC1 signaling and disruption of neuronal lamination during corticogenesis

  2. Several novel splice isoforms of STRADalpha that differentially affect the kinase activity, complex assembly, subcellular localization of LKB1 (show STK11 Antibodies) and the activation of the LKB1 (show STK11 Antibodies)-dependent AMPK (show PRKAA1 Antibodies) pathway were discovered.

  3. study describes structure of the core heterotrimeric LKB1 (show STK11 Antibodies)-STRADalpha-MO25alpha (show CAB39 Antibodies) complex, revealing an unusual allosteric mechanism of LKB1 (show STK11 Antibodies) activation; structure also reveals how mutations in Peutz-Jeghers syndrome & sporadic cancers impair LKB1 (show STK11 Antibodies) function

  4. Identification and characterization of an LKB1 (show STK11 Antibodies)-specific adaptor protein and substrate, STRAD. Results imply that STRAD plays a key role in regulating the tumor suppressor activities of LKB1 (show STK11 Antibodies).

  5. identify a multifactored mechanism to control LKB1 (show STK11 Antibodies) localization, and they suggest that the STRADbeta-LKB1 (show STK11 Antibodies) complex might possess unique functions in the nucleus

  6. LKB1 (show STK11 Antibodies) deacetylation is regulated by SIRT1 (show SIRT1 Antibodies) and that this in turn influences its intracellular localization, association with STRAD, kinase activity, and ability to activate AMPK (show PRKAA1 Antibodies).

  7. STRADalpha.MO25alpha complexes containing LKB1 (show STK11 Antibodies) variants were equally effective at phosphorylating and activating AMPK (show PRKAA1 Antibodies), BRSK1 (show BRSK1 Antibodies), and BRSK2 (show BRSK2 Antibodies)

  8. These data define a brush border induction pathway downstream of the Lkb1 (show STK11 Antibodies)/Strad/Mo25 (show CAB39 Antibodies) polarization complex, yet separate from other polarity events.

  9. ATP and MO25alpha (show CAB39 Antibodies) cooperate to maintain STRADalpha in an "active" closed conformation required for LKB1 (show STK11 Antibodies) activation.

Mouse (Murine) STE20-Related Kinase Adaptor alpha (STRADA) interaction partners

  1. Quantitative PCR revealed significantly reduced LKB1 (show STK11 Antibodies), MO25alpha (show CAB39 Antibodies), and STRADbeta mRNA in LKB1 (show STK11 Antibodies)(-/-) muscle. These findings demonstrate that the LKB1 (show STK11 Antibodies)-MO25 (show CAB39 Antibodies)-STRAD complex is the principal AMPKK in skeletal muscle.

  2. aberrant nuclear accumulation of LKB1 (show STK11 Antibodies) caused by STRADalpha deficiency contributes to hyperactivation of mTORC1 signaling and disruption of neuronal lamination during corticogenesis

STRADA Antigen Profile

Antigen Summary

The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known.

Alternative names and synonyms associated with STRADA

  • STE20-related kinase adaptor alpha (STRADA) antibody
  • ste20-related kinase adaptor alpha (strada) antibody
  • STE20-related kinase adaptor alpha (strada) antibody
  • STE20-related kinase adaptor alpha (Strada) antibody
  • 2610019A05Rik antibody
  • 6030402H20Rik antibody
  • AI480680 antibody
  • E130112C09Rik antibody
  • fj99g05 antibody
  • Lyk5 antibody
  • NY-BR-96 antibody
  • PMSE antibody
  • Stlk antibody
  • STRAD antibody
  • wu:fj99g05 antibody
  • zgc:56109 antibody

Protein level used designations for STRADA

protein kinase LYK5 , STE20-related kinase adapter protein alpha , STE20-related kinase adaptor alpha , STE20-related kinase adapter protein alpha-like , STE20-like pseudokinase , STRAD alpha , serologically defined breast cancer antigen NY-BR-96 , STE20-related adapter protein

739133 Pan troglodytes
334550 Danio rerio
493513 Xenopus (Silurana) tropicalis
609377 Canis lupus familiaris
100026111 Monodelphis domestica
100064638 Equus caballus
100302087 Ovis aries
100348595 Oryctolagus cuniculus
100391088 Callithrix jacchus
100472786 Ailuropoda melanoleuca
100563472 Anolis carolinensis
100588298 Nomascus leucogenys
92335 Homo sapiens
515024 Bos taurus
303605 Rattus norvegicus
72149 Mus musculus
419957 Gallus gallus
100172403 Pongo abelii
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