Protein Phosphatase 2, Catalytic Subunit, alpha Isozyme (PPP2CA) (Isoform alpha) antibody

Details for Product No. ABIN1042658
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Antigen
Synonyms pp2ac, Ppp2ca, zgc:110641, PP2A, R75353, PP2Ac, PP2CA, PP2Calpha, RP-C, Pp2a1, PPP2CA
Epitope
Isoform alpha
(17), (17), (9), (6), (5), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(68), (43), (37), (16), (12), (12), (11), (1)
Host
Mouse
(67), (8), (3), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunoprecipitation (IP)
(67), (28), (18), (18), (13), (9), (9), (8)
Pubmed 2 references available
Quantity 0.1 mL
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Catalog No. ABIN1042658
576.05 $
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Immunogen Peptide from rat PP2A isoform alpha
Clone 2G9
Isotype IgG1
Specificity Rcognizes very well isoforms alpha and rat delta, weakly the human beta isoform, very weakly the rabbit gamma isoform
Cross-Reactivity Human, Mouse (Murine)
Cross-Reactivity (Details) Predicted to react with Porcine,Rabbit,Chicken,Xenopus
Characteristics Myeloma fusion partners:
X63-Ag8.653
Purification Protein G
Alternative Name PP2A alpha
Background Synonyms:
B/PR55, B/PR55 alpha, PP2A alpha antibody,PP2A C antibody,PP2A-alpha antibody,PP2AA_HUMAN antibody,PP2Ac antibody,PP2CA antibody
UniProt P63331
Research Area Signaling, Kinases/Phosphatases
Application Notes Optimal antibody dilution should be determined by titration, however as a guideline try up to 1:1,000 for western blot
Comment

PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS, 0.1 % sodium azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
anti-Protein Phosphatase 2, Catalytic Subunit, alpha Isozyme (PPP2CA) (Isoform alpha) antibody anti-Protein Phosphatase 2, Catalytic Subunit, alpha Isozyme (PPP2CA) (Isoform alpha) antibody
Product cited in: Sontag, Hladik, Montgomery et al.: "Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis." in: Journal of neuropathology and experimental neurology, Vol. 63, Issue 10, pp. 1080-91, 2004 (PubMed).

Sontag, Nunbhakdi-Craig, Sontag et al.: "Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 11, pp. 2751-9, 2007 (PubMed).

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