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Protein Phosphatase 2, Catalytic Subunit, alpha Isozyme (PPP2CA) (Isoform alpha) antibody

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Synonyms pp2ac, Ppp2ca, zgc:110641, PP2A, R75353, PP2Ac, PP2CA, PP2Calpha, RP-C, Pp2a1, PPP2CA
Isoform alpha
(24), (17), (13), (11), (9), (9), (4), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(105), (70), (53), (11), (6), (6), (5), (2), (2), (1), (1)
(103), (10), (4), (3), (3)
Clonality (Clone)
Monoclonal ()
(3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB), Immunoprecipitation (IP)
(100), (42), (24), (23), (15), (12), (10), (6), (2), (2)
Pubmed 2 references available
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Quantity 0.1 mL
Shipping to United States ( )
Availability Will be delivered in 5 to 6 Business Days
Immunogen Peptide from rat PP2A isoform alpha
Clone 2G9
Isotype IgG1
Specificity Rcognizes very well isoforms alpha and rat delta, weakly the human beta isoform, very weakly the rabbit gamma isoform
Cross-Reactivity Human, Mouse (Murine)
Cross-Reactivity (Details) Predicted to react with Porcine,Rabbit,Chicken,Xenopus
Characteristics Myeloma fusion partners:
Purification Protein G
Alternative Name PP2A alpha (PPP2CA Antibody Abstract)
Background Synonyms:
B/PR55, B/PR55 alpha, PP2A alpha antibody,PP2A C antibody,PP2A-alpha antibody,PP2AA_HUMAN antibody,PP2Ac antibody,PP2CA antibody
UniProt P63331
Research Area Signaling, Kinases/Phosphatases
Pathways PI3K-Akt Signaling
Application Notes Optimal antibody dilution should be determined by titration, however as a guideline try up to 1:1,000 for western blot

PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS, 0.1 % sodium azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
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Image no. 1 for anti-Protein Phosphatase 2, Catalytic Subunit, alpha Isozyme (PPP2CA) (Isoform alpha) antibody (ABIN1042658) anti-Protein Phosphatase 2, Catalytic Subunit, alpha Isozyme (PPP2CA) (Isoform alpha) antibody
Product cited in: Sontag, Nunbhakdi-Craig, Sontag et al.: "Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 11, pp. 2751-9, 2007 (PubMed).

Sontag, Hladik, Montgomery et al.: "Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis." in: Journal of neuropathology and experimental neurology, Vol. 63, Issue 10, pp. 1080-91, 2004 (PubMed).

Catalog No. ABIN1042658
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