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Details for Product No. ABIN1042658

Protein Phosphatase 2, Catalytic Subunit, alpha Isozyme (PPP2CA) (Isoform alpha) antibody

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Antigen
Synonyms PP2Ac, PP2CA, PP2Calpha, RP-C, PP2A, R75353, Pp2a1, PPP2CA, pp2ac, Ppp2ca, pp2ca, rp-c, zgc:110641
Epitope
»Alternatives Isoform alpha
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunoprecipitation (IP)
Pubmed 2 references available
Catalog no. ABIN1042658
Quantity 0.1 mL
Price
576.05 $   Plus shipping costs $45.00
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Availability Will be delivered in 5 to 6 Business Days
Immunogen Peptide from rat PP2A isoform alpha
Myeloma Fusion Partners: X63-Ag8.653
Clone 2G9
Isotype IgG1
Specificity Rcognizes very well isoforms alpha and rat delta, weakly the human beta isoform, very weakly the rabbit gamma isoform
Cross-Reactivity Human, Mouse (Murine)
Characteristics Mouse Anti-PP2A alpha [2G9]
Purification Protein G
Alternative Name PP2A alpha
Gene ID 24672
OMIM 176915
UniProt P63331
Research Area Signaling, Kinases/Phosphatases
Application Notes Optimal antibody dilution should be determined by titration, however as a guideline try up to 1:1,000 for western blot
Comment

PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Purified antibody (from supernatant) containing PBS + 0.1% sodium azide
Preservative Sodium azide
Product cited in: Sontag, Hladik, Montgomery et al.: "Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis." in: Journal of neuropathology and experimental neurology, Vol. 63, Issue 10, pp. 1080-91, 2004 (PubMed).

Sontag, Nunbhakdi-Craig, Sontag et al.: "Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 11, pp. 2751-9, 2007 (PubMed).

Alternatives for antigen "Protein Phosphatase 2, Catalytic Subunit, alpha Isozyme (PPP2CA)", type "Antibodies"
Hosts (62), (14), (2), (2), (1)
Reactivities (76), (43), (42), (14), (12), (12), (11), (1)
Applications (69), (27), (20), (18), (16), (13), (9), (7), (2)
Conjugates (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (17), (15), (3), (3), (2), (2), (1), (1), (1), (1), (1)
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