anti-Microtubule Star antibody (MTS) (C-Term)

Details for Product anti-MTS Antibody No. ABIN1042659
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Synonyms AI115466, D8Ertd766e, PP2Ac, PP2CA, PP2Calpha, RP-C
Mouse (Murine), Rat (Rattus), Human
(2), (1), (1)
(1), (1)
Clonality (Clone)
Monoclonal ()
Western Blotting (WB), Immunoprecipitation (IP)
(2), (2), (2), (1)
Pubmed 8 references available
Quantity 0.1 mL
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Availability Will be delivered in 5 to 6 Business Days
Immunogen A KLH-coupled peptide with the sequence: KLH-C-ßA-RRTPDYFL-OMe. The c-terminal sequence (as well as the carboxy-methylation) is absolutely conserved from human, mouse to yeast
Clone 2A10
Isotype IgG1
Specificity Recognises specifically the C-terminally methylated form of PP2A C subunit
Cross-Reactivity (Details) Predicted to work with: Saccharomyces cerevisiae
Characteristics Myeloma fusion partners:
Detects a band of approximately 36 kDa (predicted molecular weight: 36 kDa)
Purification Protein G
Alternative Name PP2A C (MTS Antibody Abstract)
Background Synonyms:
PP2A alpha antibody,PP2A C antibody,PP2A-alpha antibody,PP2AA_HUMAN antibody,PP2Ac antibody,PP2CA antibody,PPP2CA antibody,Protein phosphatase 2, catalytic subunit, alpha isoform antibody,Replication protein C antibody
UniProt P63331
Pathways PI3K-Akt Signaling
Application Notes Optimal antibody dilution should be determined by titration, however as a guideline try, WB: 1,500.

PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS, 0.1 % sodium azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
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Product cited in: Benziane, Björnholm, Pirkmajer et al.: "Activation of AMP-activated protein kinase stimulates Na+,K+-ATPase activity in skeletal muscle cells." in: The Journal of biological chemistry, Vol. 287, Issue 28, pp. 23451-63, 2012 (PubMed).

Li, Huang, Liang et al.: "Microcystin-LR (MCLR) induces a compensation of PP2A activity mediated by α4 protein in HEK293 cells." in: International journal of biological sciences, Vol. 7, Issue 6, pp. 740-52, 2011 (PubMed).

Finnegan, Mackey, Cotter: "A stress survival response in retinal cells mediated through inhibition of the serine/threonine phosphatase PP2A." in: The European journal of neuroscience, Vol. 32, Issue 3, pp. 322-34, 2010 (PubMed).

Hombauer, Weismann, Mudrak et al.: "Generation of active protein phosphatase 2A is coupled to holoenzyme assembly." in: PLoS biology, Vol. 5, Issue 6, pp. e155, 2007 (PubMed).

Sontag, Nunbhakdi-Craig, Sontag et al.: "Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 11, pp. 2751-9, 2007 (PubMed).

Sontag, Hladik, Montgomery et al.: "Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis." in: Journal of neuropathology and experimental neurology, Vol. 63, Issue 10, pp. 1080-91, 2004 (PubMed).

Sontag, Luangpirom, Hladik et al.: "Altered expression levels of the protein phosphatase 2A ABalphaC enzyme are associated with Alzheimer disease pathology." in: Journal of neuropathology and experimental neurology, Vol. 63, Issue 4, pp. 287-301, 2004 (PubMed).

Fellner, Lackner, Hombauer et al.: "A novel and essential mechanism determining specificity and activity of protein phosphatase 2A (PP2A) in vivo." in: Genes & development, Vol. 17, Issue 17, pp. 2138-50, 2003 (PubMed).

Catalog No. ABIN1042659
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