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Details for Product No. ABIN108727

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 (CEACAM5) antibody

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Antigen
Synonyms CD66e, CEA, Psg30, 1600029H12Rik, RGD1311281, CEACAM5, CEACAM
Reactivity
»Alternatives Human
Host
»Alternatives Mouse (Murine)
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Flow Cytometry (FACS), Cell-ELISA (cELISA), ELISA, Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
Pubmed 13 references available
Catalog no. ABIN108727
Quantity 100 µg
Price
450.12 $   Plus shipping costs $45.00
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Availability Will be delivered in 5 to 6 Business Days
Immunogen immunisation with extracted protein of CEACAM5
Clone 26-3-13
Isotype IgG1
Specificity Anti-human CEACAM5 (CEA, CD66e)
Purification Protein G
Alternative Name CEACAM5
Background CEACAM5 or CEA is the name-giving member of the CEACAM family. CEACAM5 is used as a tumor marker for early detection of recurrent disease and is a potential target of tumor imaging, drugs and immunotargeting. 26/3/13 can be used to distinguish CEACAM5 from all other CEACAM and probably all pregnancy-specific glycoproteins molecules.
UniProt P06731
Research Area Cancer
Application Notes Flow cytometry: 1.2 µg/10^6 cells
ELISA: 1:200 - 1:400
CELISA: 1:200 Western Blot: 4 µg/mL
Immunohistology: 1-2 µg/10^6 cells (on cryosections)
For each application a titration should be performed to determine the optimal concentration.
Comment

Synonyms: CD66e, CEA

Restrictions For Research Use only
Concentration 1 mg/mL
Buffer PBS, pH 7.2
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C
Storage Comment short term: 2 °C - 8 °C, long term: -20 °C
Product cited in: Saeland, Belo, Mongera et al.: "Differential glycosylation of MUC1 and CEACAM5 between normal mucosa and tumour tissue of colon cancer patients." in: International journal of cancer. Journal international du cancer, 2011 (PubMed).

Background publications Schmitter, Agerer, Peterson et al.: "Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens." in: The Journal of experimental medicine, Vol. 199, Issue 1, pp. 35-46, 2004 (PubMed).

Partyka, McDonald, Maupin et al.: "Comparison of surgical and endoscopic sample collection for pancreatic cyst fluid biomarker identification." in: Journal of proteome research, Vol. 11, Issue 5, pp. 2904-11, 2012 (PubMed).

Peng, Oberst, Huang et al.: "The CEA/CD3-bispecific antibody MEDI-565 (MT111) binds a nonlinear epitope in the full-length but not a short splice variant of CEA." in: PLoS ONE, Vol. 7, Issue 5, pp. e36412, 2012 (PubMed).

Drukker, Tang, Ardehali et al.: "Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells." in: Nature biotechnology, Vol. 30, Issue 6, pp. 531-42, 2012 (PubMed).

Strobel, Strobel, Bross et al.: "Effects of human bone marrow stroma on the growth of human tumor cells." in: Cancer research, Vol. 49, Issue 4, pp. 1001-7, 1989 (PubMed).

Grunert, AbuHarfeil, Schwarz et al.: "Two CEA and three NCA species, although distinguishable by monoclonal antibodies, have nearly identical peptide patterns." in: International journal of cancer. Journal international du cancer, Vol. 36, Issue 3, pp. 357-62, 1985 (PubMed).

Thompson, Mössinger, Reichardt et al.: "A polymerase-chain-reaction assay for the specific identification of transcripts encoded by individual carcinoembryonic antigen (CEA)-gene-family members." in: International journal of cancer. Journal international du cancer, Vol. 55, Issue 2, pp. 311-9, 1993 (PubMed).

Krop-Watorek, Laskowska, Salwa et al.: "CEA-related proteins on human urothelial cell lines of different transformation grades." in: Cancer letters, Vol. 139, Issue 1, pp. 15-22, 1999 (PubMed).

Schölzel, Zimmermann, Schwarzkopf et al.: "Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas." in: The American journal of pathology, Vol. 156, Issue 2, pp. 595-605, 2000 (PubMed).

Baczy?ska, Wietrzyk, Madej et al.: "The tumorigenic potential of human CX-1 colon adenocarcinoma cells depends on carcinoembryonic antigen (CEACAM5) expression." in: Cellular & molecular biology letters, Vol. 8, Issue 2, pp. 471-86, 2003 (PubMed).

Kammerer, Riesenberg, Weiler et al.: "The tumour suppressor gene CEACAM1 is completely but reversibly downregulated in renal cell carcinoma." in: The Journal of pathology, Vol. 204, Issue 3, pp. 258-67, 2004 (PubMed).

Nöckel, van den Engel, Winter et al.: "Characterization of gastric adenocarcinoma cell lines established from CEA424/SV40 T antigen-transgenic mice with or without a human CEA transgene." in: BMC cancer, Vol. 6, pp. 57, 2006 (PubMed).

Alternatives for antigen "Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 (CEACAM5)", type "Antibodies"
Hosts (213), (71), (10), (3), (1), (1)
Reactivities (285), (6), (2)
Applications (127), (109), (102), (52), (49), (47), (41), (22), (21), (16), (14), (7), (3), (1), (1), (1), (1)
Conjugates (12), (7), (5), (1), (1)
Epitopes (2), (2), (1), (1), (1)
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