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Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 (CEACAM5) antibody

Details for Product No. ABIN108727, Supplier: Login to see
Antigen
  • CEACAM5
  • CEA
  • CEACAM
  • RGD1311281
  • CD66e
  • 1600029H12Rik
  • Psg30
Reactivity
Human
238
13
7
Host
Mouse
150
86
5
3
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
13
9
4
3
2
1
Application
Cell-ELISA (cELISA), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), ELISA, Western Blotting (WB)
100
74
72
55
44
38
29
15
13
11
7
7
7
3
3
1
1
1
1
1
1
1
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Immunogen immunisation with extracted protein of CEACAM5
Clone 26-3-13
Isotype IgG1
Specificity Anti-human CEACAM5 (CEA, CD66e)
Purification Protein G
Alternative Name CEACAM5 (CEACAM5 Antibody Abstract)
Background CEACAM5 or CEA is the name-giving member of the CEACAM family. CEACAM5 is used as a tumor marker for early detection of recurrent disease and is a potential target of tumor imaging, drugs and immunotargeting. 26/3/13 can be used to distinguish CEACAM5 from all other CEACAM and probably all pregnancy-specific glycoproteins molecules.
UniProt P06731
Research Area Cancer
Pathways
Application Notes Flow cytometry: 1.2 µg/10^6 cells
ELISA: 1:200 - 1:400
CELISA: 1:200 Western Blot: 4 µg/mL
Immunohistology: 1-2 µg/10^6 cells (on cryosections)
For each application a titration should be performed to determine the optimal concentration.
Comment

Synonyms: CD66e, CEA

Restrictions For Research Use only
Concentration 1 mg/mL
Buffer PBS, pH 7.2
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C
Storage Comment short term: 2 °C - 8 °C, long term: -20 °C
Supplier Images
 image for anti-Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 (CEACAM5) antibody (ABIN108727) Specificity testing of 26/3/13. Members of the CEA family were expressed on BOSC cell...
 image for anti-Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 (CEACAM5) antibody (ABIN108727) FACS analysis of BOSC23 cells using 26/3/13. BOSC23 cells were transiently transfecte...
Flow Cytometry (FACS) image for anti-Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 (CEACAM5) antibody (ABIN108727) FACS analysis of BOSC23 cells using 26/3/13. BOSC23 cells were transiently transfecte...
Flow Cytometry (FACS) image for anti-Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 (CEACAM5) antibody (ABIN108727) Specificity testing of 26/3/13. BOSC23 cells were transiently transfected with expres...
Product cited in: Saeland, Belo, Mongera et al.: "Differential glycosylation of MUC1 and CEACAM5 between normal mucosa and tumour tissue of colon cancer patients." in: International journal of cancer. Journal international du cancer, 2011 (PubMed).

Background publications Drukker, Tang, Ardehali et al.: "Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells." in: Nature biotechnology, Vol. 30, Issue 6, pp. 531-42, 2012 (PubMed).

Peng, Oberst, Huang et al.: "The CEA/CD3-bispecific antibody MEDI-565 (MT111) binds a nonlinear epitope in the full-length but not a short splice variant of CEA." in: PLoS ONE, Vol. 7, Issue 5, pp. e36412, 2012 (PubMed).

Partyka, McDonald, Maupin et al.: "Comparison of surgical and endoscopic sample collection for pancreatic cyst fluid biomarker identification." in: Journal of proteome research, Vol. 11, Issue 5, pp. 2904-11, 2012 (PubMed).

Nöckel, van den Engel, Winter et al.: "Characterization of gastric adenocarcinoma cell lines established from CEA424/SV40 T antigen-transgenic mice with or without a human CEA transgene." in: BMC cancer, Vol. 6, pp. 57, 2006 (PubMed).

Kammerer, Riesenberg, Weiler et al.: "The tumour suppressor gene CEACAM1 is completely but reversibly downregulated in renal cell carcinoma." in: The Journal of pathology, Vol. 204, Issue 3, pp. 258-67, 2004 (PubMed).

Schmitter, Agerer, Peterson et al.: "Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens." in: The Journal of experimental medicine, Vol. 199, Issue 1, pp. 35-46, 2004 (PubMed).

Baczy?ska, Wietrzyk, Madej et al.: "The tumorigenic potential of human CX-1 colon adenocarcinoma cells depends on carcinoembryonic antigen (CEACAM5) expression." in: Cellular & molecular biology letters, Vol. 8, Issue 2, pp. 471-86, 2003 (PubMed).

Schölzel, Zimmermann, Schwarzkopf et al.: "Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas." in: The American journal of pathology, Vol. 156, Issue 2, pp. 595-605, 2000 (PubMed).

Krop-Watorek, Laskowska, Salwa et al.: "CEA-related proteins on human urothelial cell lines of different transformation grades." in: Cancer letters, Vol. 139, Issue 1, pp. 15-22, 1999 (PubMed).

Hammarström: "The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues." in: Seminars in cancer biology, Vol. 9, Issue 2, pp. 67-81, 1999 (PubMed).

Thompson, Mössinger, Reichardt et al.: "A polymerase-chain-reaction assay for the specific identification of transcripts encoded by individual carcinoembryonic antigen (CEA)-gene-family members." in: International journal of cancer. Journal international du cancer, Vol. 55, Issue 2, pp. 311-9, 1993 (PubMed).

Grunert, AbuHarfeil, Schwarz et al.: "Two CEA and three NCA species, although distinguishable by monoclonal antibodies, have nearly identical peptide patterns." in: International journal of cancer. Journal international du cancer, Vol. 36, Issue 3, pp. 357-62, 1985 (PubMed).

Strobel, Strobel, Bross et al.: "Effects of human bone marrow stroma on the growth of human tumor cells." in: Cancer research, Vol. 49, Issue 4, pp. 1001-7, 1989 (PubMed).