Paired Box 5 (PAX5) (AA 235-382) antibody

Details for Product No. ABIN1098104
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Antigen
Synonyms PAX5, BSAP, Pax-5, pax5-a, RGD1565236, EBB-1, KLP, Pax[Zf-b], noi, pax2.1, pax2a, paxzf-b
Epitope
AA 235-382
(23), (9), (9), (8), (7), (5), (4), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(108), (38), (19), (13), (12), (12), (1), (1), (1), (1)
Host
Mouse
(85), (22), (6), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(4), (4), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(79), (43), (37), (23), (17), (10), (3), (2), (2), (2), (2), (1), (1)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN1098104
396.00 $
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Immunogen Purified recombinant fragment of human PAX5 (AA 235-382) expressed in E. coli.
Clone 7D3
Isotype IgG1
Purification Purified
Alternative Name PAX5
Background Synonyms:
BSAP
This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t (9,14) (p13,q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.
Molecular Weight 45 kDa
Gene ID 5079
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Buffer PBS with 0.05 % sodium azide and 0.5 % protein stabilizer
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-Paired Box 5 (PAX5) (AA 235-382) antibody Red: Control Antigen (100 ng), Purple: Antigen (10 ng), Green: Antigen (50ng), Blue: Antigen (100 ng)
anti-Paired Box 5 (PAX5) (AA 235-382) antibody (2) Figure 2: Immunohistochemical analysis of paraffin-embedded brain tumors tissues using PAX5 mouse mAb with DAB staining.
anti-Paired Box 5 (PAX5) (AA 235-382) antibody (3) Figure 3: Immunohistochemical analysis of paraffin-embedded endometrial cancer tissues using PAX5 mouse mAb with DAB staining.
anti-Paired Box 5 (PAX5) (AA 235-382) antibody (4) Figure 1: Western blot analysis using PAX5 mAb against human PAX5 recombinant protein. (Expected MW is 41.2 kDa)
Product cited in: Nasr, Rosenthal, Syrbu: "Expression profiling of transcription factors in B- or T-acute lymphoblastic leukemia/lymphoma and burkitt lymphoma: usefulness of PAX5 immunostaining as pan-Pre-B-cell marker." in: American journal of clinical pathology, Vol. 133, Issue 1, pp. 41-8, 2009 (PubMed).

OBrien, Morin, Ouellette et al.: "The Pax-5 gene: a pluripotent regulator of B-cell differentiation and cancer disease." in: Cancer research, Vol. 71, Issue 24, pp. 7345-50, 2011 (PubMed).

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