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Details for Product No. ABIN1105223

Apoptotic Chromatin Condensation Inducer 1 (ACIN1) (N-Term), (AA 1-523), (N-Term) antibody

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ACINUS, ACN, fSAP152, Acn, Acinus, C79325, acinusL, acinusS, mKIAA0670, 2610036I19Rik, 2610510L13Rik, acinus, acinusb, fi14c05, wu:fe06a10, wu:fi14c05, acinusa, acinusl, wu:fb04g06, wu:fb40f03, wu:fb6 ... show more
»Alternatives N-Term, AA 1-523, N-Term
»Alternatives Human
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN1105223
Quantity 0.1 mg
357.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen GST-human AcinusL fusion protein corresponding to N-terminal amino acids (1~523 a.a.)
Clone 3H8
Isotype IgG1
Specificity This antibody reacts withAcinusL.
Purification Protein A agarose beads
Alternative Name Acinus / ACIN1
Background Chromatin condensation and nuclear fragmentation (CCNF) are hallmarks of apoptosis. CCNF is triggered by the activation of members of the caspase family, caspase-activated DNase (CAD/DFF40) and several novel proteins including AIF and CIDE. A new inducer of chromatin condensation was recently identified and designated Acinus (Apoptotic Chromatin Condensation Inducer in the Nucleus). The 220 kDa Acinus protein is cleaved by caspase-3 and an additional unknown protease to generate a 17 kDa peptide that which causes chromatin condensation in vitro when added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Three different spliced forms of Acinus have been identified in human and mouse and designated AcinusL, AcinusS, and AcinusS'. Acinus is ubiquitously expressed.
Alternate names: Apoptotic chromatin condensation inducer in the nucleus, KIAA0670
Gene ID 22985
NCBI Accession NP_001158286.1
UniProt Q9UKV3
Research Area Cell Cycle, Apoptosis/Necrosis
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 50% glycerol, pH 7.2. Contains no preservatives.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.
Expiry Date 12 months
Background publications Sahara, Aoto, Eguchi et al.: "Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation." in: Nature, Vol. 401, Issue 6749, pp. 168-73, 1999 (PubMed).

Alternatives for antigen "Apoptotic Chromatin Condensation Inducer 1 (ACIN1)", type "Antibodies"
Hosts (132), (5)
Reactivities (130), (40), (25), (24), (24), (12)
Applications (115), (41), (35), (20), (13), (12), (8), (2), (2), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (35), (18), (12), (4), (4), (4), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)