ACIN1 antibody (AA 760-810)

Catalog No. ABIN6990317

The Rabbit Polyclonal anti-ACIN1 antibody is suitable to detect ACIN1 in samples from Human. It has been validated for WB, ELISA, ICC and IF.

Quick Overview for ACIN1 antibody (AA 760-810) (ABIN6990317)

Target: ACIN1 (Apoptotic Chromatin Condensation Inducer 1 (ACIN1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACIN1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Product Details anti-ACIN1 Antibody

Binding Specificity: AA 760-810

Purification: Acinus Antibody is affinity chromatography purified via peptide column.

Immunogen: Acinus antibody was raised against a 35 amino acid peptide near the center of human Acinus. The immunogen is located within amino acids 760 - 810 of Acinus.

Isotype: IgG

Application Details

Application Notes: Acinus antibody can be used for detection of Acinus by Western blot at 1 μ,g/mL. A 220 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Acinus Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: Acinus antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for ACIN1

Target: ACIN1 (Apoptotic Chromatin Condensation Inducer 1 (ACIN1))

Alternative Name: Acinus

Background: Acinus Antibody: Chromatin condensation and nuclear fragmentation (CCNF) is the hallmark of apoptosis. CCNF is triggered by the activation of members of caspase family, caspase activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE. A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by caspase-3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse and designated AcinusL, AcinusS and AcinusS'.

Molecular Weight: 220 kDa

Gene ID: 22985

UniProt: Q9UKV3