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Details for Product No. ABIN1105754

Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (Extracellular Domain) antibody (FITC)

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Synonyms HVEB, PRR2, CD112, PVRR2, MPH, Pvr, Pvs, Cd112, AI325026, AI987993, nectin-2, prr2
»Alternatives Extracellular Domain
»Alternatives Human, Mouse (Murine)
Clonality (Clone) Monoclonal ()
»Alternatives Western Blotting (WB), Immunoprecipitation (IP), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro))
Pubmed 3 references available
Catalog no. ABIN1105754
Quantity 0.1 mg
731.50 $   Plus shipping costs $45.00
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Immunogen Extracellular domain of mouse nectin-2
Clone 502-57
Isotype IgG2a
Specificity This antibody detects Nectin-2 at extracellular domain.
Purification Protein G
Alternative Name CD112 / Nectin 2
Background Nectin (originally isolated as poliovirus receptor-related protein (PRR)) is a cell-cell adhesion molecule of the immunoglobulin supergene family. Nectin is colocalized with afadin at cadherin-based cell-cell adherence junctions in various tissues and cell lines. The nectin family consist of nectin-1, nectin-2 and nectin-3. Nectin-2 also known as PRR2 or CD112 is a plasma membrane adhesion molecule localized at adherens junctions which is widely expressed in various cell lines including neuronal, endothelial, epithelial and hematopoietic cells. Next to its role in adherens junctions it functions as alphaherpus virus receptor and acts also as intercellular adhesion molecule and pseudorabies virus receptor. Disruption of mouse nectin-2 leads to infertility of male mice.
Alternate names: HVEB, Herpes virus entry mediator B, Nectin-2, Nectin-2, PRR2, PVRL2, Poliovirus receptor- related protein 2
UniProt P32507
Research Area CD Antigens, Surface Receptors of Immune Cells
Restrictions For Research Use only
Format Liquid
Concentration 0.1 mg/mL
Buffer PBS, 0.02% sodium azide, 0.1% bovine serum albumin
Preservative Sodium azide
Storage 4 °C
Storage Comment Store at 2 - 8 °C.
Expiry Date 12 months
Background publications Sakisaka, Nakanishi, Takahashi et al.: "Different behavior of l-afadin and neurabin-II during the formation and destruction of cell-cell adherens junction." in: Oncogene, Vol. 18, Issue 8, pp. 1609-17, 1999 (PubMed).

Takahashi, Nakanishi, Miyahara et al.: "Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein." in: The Journal of cell biology, Vol. 145, Issue 3, pp. 539-49, 1999 (PubMed).

Kawabe, Nakanishi, Asada et al.: "Pilt, a novel peripheral membrane protein at tight junctions in epithelial cells." in: The Journal of biological chemistry, Vol. 276, Issue 51, pp. 48350-5, 2001 (PubMed).

Alternatives for antigen "Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2)", type "Antibodies"
Hosts (32), (19), (10)
Reactivities (58), (24), (18), (17)
Applications (36), (23), (14), (14), (10), (9), (8), (7), (3), (2), (1), (1)
Conjugates (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (3), (1), (1), (1), (1)