CD38 antibody (APC)

Catalog No. ABIN1106333

Product Details anti-CD38 Antibody (APC)

Target: CD38

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD38 antibody is conjugated to APC

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Specificity: Clone T16 produces mouse IgG1 immunoglobulins reactive with a 45 kDa antigen on lymphocytes [3]. CD38, clone T16, is widely used in flow cytometry to study T cell activation, B cell differentiation and in monitoring immunodeficiency diseases. CD38 is also reactive with multiple myelomas, most cases of ALL (both T and B lineage) and some cases of AML. In immunohistochemistry CD38, clone T16, reacts strongly with plasma cells and cortical thymocytes, less strongly with germinal center B cells. In clinical research CD38 is mainly used for leukemia and lymphoma typing and detection of plasma cells [4].

Purification: Affinity chromatography

Clone: T16

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: 0.01 M sodium phosphate, 0.15 M NaCl, pH 7.3, 0.2 % BSA, 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C. Fluorochrome labelled product is photosensitive and should be protected from light.

Target Details for CD38

Target: CD38

Abstract: CD38 Products

Background: CD38 is present in low density on human B cells and pre-B cells, subsets of CD4 and CD8 T cells, NK cells and monocytes. CD38 is also found in high density on Ig secreting plasma cells, germinal center B cells, mitogen-activated T cells, and several B and T cells. CD38 is a type II membrane glycoprotein, with the transmembrane sequence near the N-terminus. Antibodies to human CD38 have a wide range of biological effects, incuding the induction of B and T cell proliferation, protection of B cells from apoptosis, inhibition of B lymphopoiesis and enhancement of macrophage APC function [2].Synonyms: ADP-ribosyl cyclase 1, Cyclic ADP-ribose hydrolase 1, T10, cADPr hydrolase 1

Gene ID: 952

NCBI Accession: NP_001766

UniProt: P28907