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FAS antibody (Fas (TNF Receptor Superfamily, Member 6))

Details for Product anti-FAS Antibody No. ABIN1106610, Supplier: Log in to see
Antigen
  • AI196731
  • APO1
  • APT1
  • CD95
  • TNFR6
  • Tnfrsf6
  • lpr
  • TNFRSF6
  • ALPS1A
  • APO-1
  • FAS1
  • FASTM
  • A630082H08Rik
  • FAS
Alternatives
anti-Human FAS antibody for Immunohistochemistry (Paraffin-embedded Sections)
Reactivity
Human
629
101
81
11
7
5
4
3
3
3
2
2
1
1
Host
Mouse
417
286
11
6
4
3
3
Clonality (Clone)
Monoclonal ()
Conjugate
This FAS antibody is un-conjugated
71
62
48
30
14
7
6
6
4
4
4
4
4
4
4
3
3
2
2
2
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
335
283
198
131
104
73
60
54
46
44
23
13
12
8
7
5
4
4
3
3
3
2
2
2
1
1
1
1
Supplier
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Immunogen Recombinant human Fas
Clone UB2
Isotype IgG1
Specificity This antibody recognizes the human Fas antigen specifically.
No Cross-Reactivity Mouse (Murine)
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ammonium sulfate precipitation and affinity chromatography on protein A agarose
Alternative Name CD95 / FAS (FAS Antibody Abstract)
Background It is now widely accepted that apoptosis plays an important role in the selection of immature thymocytes and Ag-primed peripheral T cells. Fas antigen is a cell-surface protein that mediates apoptosis. It is expressed in various tissues including the thymus and has structural homology with a number of cell-surface receptors, including tumor necrosis factor receptor and nerve growth factor receptor.Synonyms: APT1, Apo-1 antigen, FAS1, FASLG receptor, TNFRSF6, Tumor necrosis factor receptor superfamily member 6
Gene ID 355
NCBI Accession NP_000034
UniProt P25445
Pathways p53 Signaling, Apoptosis, TCR Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Reconstitution Prepare a stock solution by dissolving the lyophilized antibody in 100 μL of distilled water.
Buffer PBS ( pH 7.2), 0.09 % NaN3, 1 % sucrose
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8 °C. Following reconstitution store (in aliquots) at -20 °C.
Supplier Images
Flow Cytometry (FACS) image for anti-FAS antibody (Fas (TNF Receptor Superfamily, Member 6)) (ABIN1106610) anti-Fas (TNF Receptor Superfamily, Member 6) (FAS) antibody
Product cited in: Hata, Matsuzaki, Takeya et al.: "Expression of Fas/Apo-1 (CD95) and apoptosis in tumor cells from patients with plasma cell disorders." in: Blood, Vol. 86, Issue 5, pp. 1939-45, 1995 (PubMed).

Background publications Vega, Jazirehi, Huerta-Yepez et al.: "Rituximab-induced inhibition of YY1 and Bcl-xL expression in Ramos non-Hodgkin's lymphoma cell line via inhibition of NF-kappa B activity: role of YY1 and Bcl-xL in Fas resistance and chemoresistance, respectively." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 4, pp. 2174-83, 2005 (PubMed).

Hauptschein, Sloan, Torella et al.: "Functional proteomic screen identifies a modulating role for CD44 in death receptor-mediated apoptosis." in: Cancer research, Vol. 65, Issue 5, pp. 1887-96, 2005 (PubMed).

Mezosi, Wang, Utsugi et al.: "Induction and regulation of Fas-mediated apoptosis in human thyroid epithelial cells." in: Molecular endocrinology (Baltimore, Md.), Vol. 19, Issue 3, pp. 804-11, 2005 (PubMed).

Suhara, Fukuo, Yasuda et al.: "Homocysteine enhances endothelial apoptosis via upregulation of Fas-mediated pathways." in: Hypertension, Vol. 43, Issue 6, pp. 1208-13, 2004 (PubMed).

Suhara, Kim, Kirshenbaum et al.: "Suppression of Akt signaling induces Fas ligand expression: involvement of caspase and Jun kinase activation in Akt-mediated Fas ligand regulation." in: Molecular and cellular biology, Vol. 22, Issue 2, pp. 680-91, 2001 (PubMed).

Shinohara, Yagita, Ikawa et al.: "Fas drives cell cycle progression in glioma cells via extracellular signal-regulated kinase activation." in: Cancer research, Vol. 60, Issue 6, pp. 1766-72, 2000 (PubMed).

Sata, Suhara, Walsh: "Vascular endothelial cells and smooth muscle cells differ in expression of Fas and Fas ligand and in sensitivity to Fas ligand-induced cell death: implications for vascular disease and therapy." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 20, Issue 2, pp. 309-16, 2000 (PubMed).

Hiromatsu, Hoshino, Yagita et al.: "Functional Fas ligand expression in thyrocytes from patients with Graves' disease." in: The Journal of clinical endocrinology and metabolism, Vol. 84, Issue 8, pp. 2896-902, 1999 (PubMed).

Kuwano, Miyazaki, Hagimoto et al.: "The involvement of Fas-Fas ligand pathway in fibrosing lung diseases." in: American journal of respiratory cell and molecular biology, Vol. 20, Issue 1, pp. 53-60, 1999 (PubMed).

Dai, Price, Brunner et al.: "Fas ligand is present in human erythroid colony-forming cells and interacts with Fas induced by interferon gamma to produce erythroid cell apoptosis." in: Blood, Vol. 91, Issue 4, pp. 1235-42, 1998 (PubMed).

Ando, Hiroishi, Kaneko et al.: "Perforin, Fas/Fas ligand, and TNF-alpha pathways as specific and bystander killing mechanisms of hepatitis C virus-specific human CTL." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 158, Issue 11, pp. 5283-91, 1997 (PubMed).

Boirivant, Pica, DeMaria et al.: "Stimulated human lamina propria T cells manifest enhanced Fas-mediated apoptosis." in: The Journal of clinical investigation, Vol. 98, Issue 11, pp. 2616-22, 1997 (PubMed).

Yonehara, Ishii, Yonehara: "A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor." in: The Journal of experimental medicine, Vol. 169, Issue 5, pp. 1747-56, 1989 (PubMed).

Kobayashi, Hamamoto, Yamamoto et al.: "Anti-Fas monoclonal antibody is cytocidal to human immunodeficiency virus-infected cells without augmenting viral replication." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 24, pp. 9620-4, 1991 (PubMed).

Watanabe-Fukunaga, Brannan, Copeland et al.: "Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis." in: Nature, Vol. 356, Issue 6367, pp. 314-7, 1992 (PubMed).