p53 Signaling

p53 is one of the most prominent tumor suppressors and is often called “the guardian of the genome”. Mutations of p53 or parts of its regulatory circuit are found in almost all cancers, which highlights its importance. It is conserving the stability of the genome by preventing mutations caused by cellular stress or DNA damage. p53 stabilizes the genome by regulating the expression of a wide variety of genes involved in Apoptosis, Inhibition of cell cycle progression, Differentiation, Growth arrest and accelerated DNA repair. p53 is a sequence-specific DNAbinding transcription factor which is maintained at low levels in mammalian cells which are not under cellular stress since p53 has a very short half-life. This is achieved through the continuous ubiquitination of p53 by its suppressor MDM2 and its subsequent degradation by the 26S Proteasome. Signals of cellular stress, like for example DNA damage, suppress the ubiquitylation of p53 and lead to its stabilization and activation. Once p53 is activated it binds to the regulatory elements of its downstream targets and regulates their transcription. This in turn starts several cellular programs which account for the different tumor-suppressing functions of p53.


Antigens in this category:
BAI1 (Brain-Specific Angiogenesis Inhibitor 1): BAI1 antibodies BAI1 ELISA Kits BAI1 Proteins
SERPINE1 (serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1): SERPINE1 antibodies SERPINE1 ELISA Kits SERPINE1 Proteins
CD82 (CD82 Molecule): CD82 antibodies CD82 ELISA Kits CD82 Proteins
PRSS55 (Protease, Serine, 55): PRSS55 antibodies   PRSS55 Proteins
SERPINB5 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 5): SERPINB5 antibodies SERPINB5 ELISA Kits SERPINB5 Proteins


Antigens in this category:
APAF1 (Apoptotic Peptidase Activating Factor 1): APAF1 antibodies APAF1 ELISA Kits APAF1 Proteins
PIDD (P53-Induced Death Domain Protein): PIDD antibodies   PIDD Proteins
BBC3 (BCL2 Binding Component 3): BBC3 antibodies BBC3 ELISA Kits BBC3 Proteins
BAX (BCL2-Associated X Protein): BAX antibodies BAX ELISA Kits BAX Proteins
FAS (Fas (TNF Receptor Superfamily, Member 6)): FAS antibodies FAS ELISA Kits FAS Proteins
MRPL41 (Mitochondrial Ribosomal Protein L41): MRPL41 antibodies MRPL41 ELISA Kits MRPL41 Proteins
PMAIP1 - NOXA: PMAIP1 antibodies PMAIP1 ELISA Kits PMAIP1 Proteins
PDCD6IP (Programmed Cell Death 6 Interacting Protein): PDCD6IP antibodies PDCD6IP ELISA Kits PDCD6IP Proteins
TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b): TNFRSF10B antibodies TNFRSF10B ELISA Kits TNFRSF10B Proteins
TP53I3 (Tumor Protein P53 Inducible Protein 3): TP53I3 antibodies   TP53I3 Proteins

Core regulation

Antigens in this category:
NRAS - GTPase NRas: NRAS antibodies NRAS ELISA Kits NRAS Proteins
TP53 - p53: TP53 antibodies TP53 ELISA Kits TP53 Proteins
MDM2 (Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse)): MDM2 antibodies MDM2 ELISA Kits MDM2 Proteins

DNA repair

Antigens in this category:
RRM2B (Ribonucleotide Reductase M2 B (TP53 Inducible)): RRM2B antibodies RRM2B ELISA Kits RRM2B Proteins
XPC (Xeroderma Pigmentosum, Complementation Group C): XPC antibodies XPC ELISA Kits XPC Proteins
CRLF3 (Cytokine Receptor-Like Factor 3): CRLF3 antibodies   CRLF3 Proteins


Antigens in this category:
PRDX1 - Peroxiredoxin 1: PRDX1 antibodies PRDX1 ELISA Kits PRDX1 Proteins
PPP1R13B (Protein Phosphatase 1, Regulatory Subunit 13B): PPP1R13B antibodies PPP1R13B ELISA Kits PPP1R13B Proteins
EP300 - p300: EP300 antibodies EP300 ELISA Kits EP300 Proteins
KAT2B (K(lysine) Acetyltransferase 2B): KAT2B antibodies   KAT2B Proteins
PAG1 (phosphoprotein Associated with Glycosphingolipid Microdomains 1): PAG1 antibodies PAG1 ELISA Kits PAG1 Proteins
TANK (TRAF Family Member-Associated NFKB Activator): TANK antibodies TANK ELISA Kits TANK Proteins

Growth arrest

Antigens in this category:
CDKN1A (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1)): CDKN1A antibodies CDKN1A ELISA Kits CDKN1A Proteins
GADD45A (Growth Arrest and DNA-Damage-Inducible, alpha): GADD45A antibodies GADD45A ELISA Kits GADD45A Proteins
SFN - Stratifin: SFN antibodies SFN ELISA Kits SFN Proteins


Antigens in this category:
ATM (Ataxia Telangiectasia Mutated): ATM antibodies ATM ELISA Kits ATM Proteins
HMGB1 (High Mobility Group Box 1): HMGB1 antibodies HMGB1 ELISA Kits HMGB1 Proteins
ARFGAP1 (ADP-Ribosylation Factor GTPase Activating Protein 1): ARFGAP1 antibodies   ARFGAP1 Proteins
ATR (Ataxia Telangiectasia and Rad3 Related): ATR antibodies    
CHEK1 (Checkpoint Kinase 1): CHEK1 antibodies CHEK1 ELISA Kits CHEK1 Proteins
CHEK2 (Checkpoint Kinase 2): CHEK2 antibodies CHEK2 ELISA Kits CHEK2 Proteins
NFKB1 (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 1): NFKB1 antibodies NFKB1 ELISA Kits NFKB1 Proteins
PML (Promyelocytic Leukemia): PML antibodies PML ELISA Kits PML Proteins
SCYL1 (SCY1-Like 1 (S. Cerevisiae)): SCYL1 antibodies   SCYL1 Proteins
TRIM29 (Tripartite Motif Containing 29): TRIM29 antibodies   TRIM29 Proteins

Oncogene activation

Antigens in this category:
HRAS (V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog): HRAS antibodies HRAS ELISA Kits HRAS Proteins
MYC - C-MYC: MYC antibodies MYC ELISA Kits MYC Proteins
DMP1 (Dentin Matrix Acidic phosphoprotein 1):   DMP1 ELISA Kits DMP1 Proteins
E2F1 (E2F Transcription Factor 1): E2F1 antibodies E2F1 ELISA Kits E2F1 Proteins
NRAS - GTPase NRas: NRAS antibodies NRAS ELISA Kits NRAS Proteins
TBX2 (T-Box 2): TBX2 antibodies TBX2 ELISA Kits TBX2 Proteins
TWIST1 (Twist Homolog 1 (Drosophila)): TWIST1 antibodies TWIST1 ELISA Kits TWIST1 Proteins


Antigens in this category:
CCNG1 - Cyclin G1: CCNG1 antibodies CCNG1 ELISA Kits CCNG1 Proteins
MAP4 (Microtubule-Associated Protein 4): MAP4 antibodies MAP4 ELISA Kits MAP4 Proteins
PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D): PPM1D antibodies   PPM1D Proteins