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Estrogen Receptor Binding Site Associated, Antigen, 9 (EBAG9) antibody

Details for Product No. ABIN1107048
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Antigen
Synonyms EB9, PDAF, AI835379, Rcas1, RCAS1, MGC56608, zgc:56608, MGC84425, EBAG9, eb9, pdaf, rcas1
Reactivity
Human
(63), (26), (26), (22), (18), (17), (17)
Host
Mouse
(54), (8), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
(32), (25), (15), (14), (14), (3), (3), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Catalog No. ABIN1107048
390.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Human uterine cervical adenocarcinoma cell
Clone 22-1-1
Isotype IgM
Specificity This antibody recognizes RCAS1.
Purification Protein-L Sepharose
Alternative Name EBAG9 / RCAS1
Background RCAS1 (receptor-binding cancer antigen expressed on SiSo cells) is a novel tumoreassociated antigen expressed in human uterine and ovarian carcinomas. The predicted amino acid sequence of RCAS1 (213 a.a.) possesses an N-terminal transmembrane region and a coiled-coil structure in the C-terminal portion, indicating that RCAS1 is a type II membrane protein able to form oligomers through the coiled-coil structure. RCAS1 revealed different expression pattern from the known tumore associated antigens such as, YH206, GA733, CA125, CEA and sialyl Le molecules in human tumore cell lines. Recent study indicated RCAS1 acts as a ligand for a putative receptor present on various human cells including T, B and NK cells. RCAS1 inhibited the in vitro growth of receptor-expressing cells and induced apoptosis. It was suggested that tumore cells might evade immune surveillance by expression of RCAS1.
Alternate names: Cancer-associated surface antigen RCAS1, EB9, Estrogen receptor-binding fragment- associated gene 9 protein, PDAF, Receptor-binding cancer antigen expressed on SiSo cells
Gene ID 9166
NCBI Accession NP_004206.1
UniProt O00559
Restrictions For Research Use only
Format Liquid
Buffer 100 micrograms of IgM in 100 microliter volume of PBS containing 50% glycerol containing no preservatives 0.5 M NaCl
Preservative Azide free
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.
Expiry Date 12 months
Background publications Sonoda, Kaku, Kamura et al.: "Tumor-associated antigen 22-1-1 expression in the uterine cervical squamous neoplasias." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 4, Issue 6, pp. 1517-20, 1998 (PubMed).

Nakashima, Sonoda, Watanabe: "Inhibition of cell growth and induction of apoptotic cell death by the human tumor-associated antigen RCAS1." in: Nature medicine, Vol. 5, Issue 8, pp. 938-42, 1999 (PubMed).

Wicherek, Dutsch, Mak et al.: "Comparative analysis of RCAS1 level in neoplasms and placenta." in: Acta biochimica Polonica, Vol. 50, Issue 4, pp. 1187-94, 2004 (PubMed).

Hosts (54), (8), (3)
Reactivities (63), (26), (26), (22), (18), (17), (17)
Applications (32), (25), (15), (14), (14), (3), (3), (1), (1)
Conjugates (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (13), (9), (6), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN1107048
390.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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