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Tenascin C (TNC) antibody

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Synonyms tn, 150-225, GMEM, GP, HXB, JI, TN, TN-C, AI528729, C130033P17Rik, Hxb, Ten, cytotactin, tenascin-C, P230, tenc, wu:fk04d02
Guinea Pig, Human, Rabbit
(196), (51), (44), (5), (3), (1), (1), (1), (1), (1), (1)
(117), (78), (14), (5), (4)
Clonality (Clone)
Monoclonal ()
(18), (16), (12), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
(134), (89), (53), (51), (27), (24), (22), (21), (14), (7), (5), (4), (2), (2), (1), (1), (1), (1)
Pubmed 16 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Purified Tenascin-C from human fetal fibroblasts. Hybridoma produced by fusion between myeloma cells and Balb/c spleen cells.
Clone EB2
Isotype IgG1
Specificity The antibody clone EB2 reacts with the 4th and 5th fibronectin-like repeats of Human Tenascin-C polypeptides of Mr 250000 and 180000.
Cross-Reactivity (Details) Species reactivity (tested):Human, Guinea Pig and Rabbit.
Purification Ig Fraction
Alternative Name Tenascin / TNC / HXB (TNC Antibody Abstract)
Background Tenascins were first characterized in the early 1980's. Since then hundreds of publications on tenascin in normal tissues, pathologically reactive tissues and carcinomas have been published. However, only recently more elective studies have been done. In these studies retrospective material from pathology files has been studied as well as larger fresh material collected during several years from patients. These studies have now attempted to reveal more specific points in carcinogenesis and pathological tissue reactions. It has been demonstrated that tenascin immunoreactivity in breast carcinoma cells could be indicative of metastasis and survival. Recent studies using retrospective material showed that the expression of tenascin in invasion border of early breast cancer significantly correlates with higher risk of distant metastasis. These studies have been continued now and the preliminary results clearly suggest that expression of tenascin in invasion border of early breast cancer is significantly associated with proliferative activity and higher risk of local recurrence. This result implicates a wide application for tenascin antibodies in the breast pathology. The point is that tenascin expression may suggest situations in which even small breast carcinomas may need more intensive complementary therapy (chemotherapy etc.). Recent studies have also shown that tenascin is significantly increased in airway basement membrane of asthmatics and rapidly decreases by inhaled steroid. This result suggests that tenascin expression may be used to monitor the disease status and outcome of treatment in different types of asthma.Synonyms: Cytotactin, GMEM, GP 150-225, Glioma-associated-extracellular matrix antigen, Hexabrachion, Myotendinous antigen, Neuronectin, TN-C, Tenascin-C
Gene ID 3371
NCBI Accession NP_002151
UniProt P24821
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, 0.09 % Sodium Azide, 1.0 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Background publications Karjalainen, Laitinen, Sue-Chu et al.: "Evidence of airway inflammation and remodeling in ski athletes with and without bronchial hyperresponsiveness to methacholine." in: American journal of respiratory and critical care medicine, Vol. 161, Issue 6, pp. 2086-91, 2000 (PubMed).

Dvorak, Morgan, Lichtenstein et al.: "RNA is closely associated with human mast cell secretory granules, suggesting a role(s) for granules in synthetic processes." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 48, Issue 1, pp. 1-12, 2000 (PubMed).

Günaydin, Terhorst, Eckstein et al.: "Assessment of keratoconjunctivitis sicca in patients with fibromyalgia: results of a prospective study." in: Rheumatology international, Vol. 19, Issue 1-2, pp. 7-9, 2000 (PubMed).

Feng, Yang, Huang et al.: "Transcriptional profile of mechanically induced genes in human vascular smooth muscle cells." in: Circulation research, Vol. 85, Issue 12, pp. 1118-23, 2000 (PubMed).

Järvinen, Jozsa, Kannus et al.: "Mechanical loading regulates tenascin-C expression in the osteotendinous junction." in: Journal of cell science, Vol. 112 Pt 18, pp. 3157-66, 2000 (PubMed).

Yamamoto, Dang, Kennedy et al.: "Induction of tenascin-C in cardiac myocytes by mechanical deformation. Role of reactive oxygen species." in: The Journal of biological chemistry, Vol. 274, Issue 31, pp. 21840-6, 1999 (PubMed).

Ferrannini, Camastra: "Relationship between impaired glucose tolerance, non-insulin-dependent diabetes mellitus and obesity." in: European journal of clinical investigation, Vol. 28 Suppl 2, pp. 3-6; discussion 6-7, 1998 (PubMed).

Tsuji, Minhaz, Shioya et al.: "The importance of polymorphonuclear leukocytes in lipopolysaccharide-induced superoxide anion production and lung injury: ex vivo observation in rat lungs." in: Lung, Vol. 176, Issue 1, pp. 1-13, 1998 (PubMed).

Baughman: "Cytomegalovirus: the monster in the closet?" in: American journal of respiratory and critical care medicine, Vol. 156, Issue 1, pp. 1-2, 1997 (PubMed).

Tuori, Virtanen, Aine et al.: "The expression of tenascin and fibronectin in keratoconus, scarred and normal human cornea." in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, Vol. 235, Issue 4, pp. 222-9, 1997 (PubMed).

Törnwall, Konttinen, Uusitalo: "Immunohistochemical distribution of calcitonin gene-related peptide in nerve fibres of the anterior buccal gland of the rat." in: The Histochemical journal, Vol. 28, Issue 1, pp. 1-5, 1996 (PubMed).

Crapo, Turino: "Should the American Thoracic Society seek a separate corporate structure apart from the American Lung Association?" in: American journal of respiratory and critical care medicine, Vol. 154, Issue 1, pp. 1-5, 1996 (PubMed).

Vesaluoma, Ylätupa, Mertaniemi et al.: "Increased release of tenascin in tear fluid after photorefractive keratectomy." in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, Vol. 233, Issue 8, pp. 479-83, 1996 (PubMed).

Linnala, Kinnula, Laitinen et al.: "Transforming growth factor-beta regulates the expression of fibronectin and tenascin in BEAS 2B human bronchial epithelial cells." in: American journal of respiratory cell and molecular biology, Vol. 13, Issue 5, pp. 578-85, 1995 (PubMed).

Koukoulis, Gould, Bhattacharyya et al.: "Tenascin in normal, reactive, hyperplastic, and neoplastic tissues: biologic and pathologic implications." in: Human pathology, Vol. 22, Issue 7, pp. 636-43, 1991 (PubMed).

Howeedy, Virtanen, Laitinen et al.: "Differential distribution of tenascin in the normal, hyperplastic, and neoplastic breast." in: Laboratory investigation, a journal of technical methods and pathology, Vol. 63, Issue 6, pp. 798-806, 1991 (PubMed).

Catalog No. ABIN1109217
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