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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Keratin 18 (KRT18) antibody
|Synonyms||K18, CYK18, CK18, Krt1-18, MGC109143, cb83, dapk1, DreK18, sb:cb83, wu:fa13f02, wu:fb36b04, krt18, MGC64569, MGC75922, KRT18, MGC131121|
Trout, Cow (Bovine), Dog (Canine), Hamster, Human, Mouse (Murine), Pig (Porcine), Rat (Rattus), Sheep (Ovine), Zebrafish (Danio rerio)
Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
|5 references available|
|Price||374.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 6 to 8 Business Days|
|Alternative name||Cytokeratin 18|
|Immunogen||Human keratin K18 from HeLa cytoskeletal preparation|
|Cross-Reactivity||Cow (Bovine), Dog (Canine), Hamster, Human, Mouse (Murine), Pig (Porcine), Rat (Rattus), Sheep (Ovine)|
|Description||Cytokeratin 18 is an acidic keratin which is found primarily in non squamous epithelia andis present in a majority of adenocarcinomas and ductal carcinomas but not in squamouscell carcinomas. Cytokeratin 18 exists in combination with Cytokeratin 8, a basic keratin. Hepatocellular carcinomas have been reportedly defined by the use of antibodies thatrecognize only Cytokeratins 8 and 18.|
|Characteristics||Synonyms: Cytokeratin-18, CK18, Keratin-18, Keratin 18, KRT18, CYK18, K18, Cell proliferation-inducinggene 46 protein, Keratin type I cytoskeletal 18|
|Application Notes||Western blot. Immunohistochemistry (dilute 1: 20 with PBS): suitable for cytological material, frozen andparaffin-embedded tissue (for best performance, microwave treatment is recommended). Incubation time: 1h at 37C, extended with paraffin sections (overnight at 2-8C). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.|
|Buffer||PBS, pH 7.4, containing 0.5% BSA ans 0.09% sodium azideReconstitution: Restore in 1.0 ml distilled water.|
|Storage||Store the original vial at 2-8°C. Following reconstitution store the antibody undiluted at 2-8°C for one month or (inaliquots)at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.|
|Research Area||Signaling, Cytoskeleton, Extracellular Matrix|
|Restrictions||For Research Use only|
Bártek, Vojtĕsek, Stasková et al.: "A series of 14 new monoclonal antibodies to keratins: characterization and value in diagnostic histopathology." in: The Journal of pathology, Vol. 164, Issue 3, pp. 215-24, 1991 (PubMed).
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Ikenouchi, Matsuda, Furuse et al.: "Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail." in: Journal of cell science, Vol. 116, Issue Pt 10, pp. 1959-67, 2003 (PubMed).