Neural Cell Adhesion Molecule 1 (NCAM1) antibody (APC)

Details for Product No. ABIN111261
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Synonyms NCAM1, ncam, n-cam, CD56, MSK39, NCAM, E-NCAM, NCAM-1, Ncam, Cd56, N-CAM, N-CAM-1, NCAM-C, NCAMC, fj56g09, ncam1, wu:fj56g09
Human, Primate
(460), (81), (56), (6), (5), (5), (3), (3), (2), (2), (1), (1), (1)
(395), (86), (14), (9), (2), (2)
Clonality (Clone)
Monoclonal ()
(44), (43), (38), (14), (7), (6), (4), (4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Flow Cytometry (FACS)
(295), (206), (99), (97), (78), (76), (66), (52), (26), (20), (7), (6), (5), (4), (4), (3), (3), (3), (3), (1), (1)
Pubmed 10 references available
Quantity 100 tests
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN111261
434.50 $
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Immunogen KG-1 human acute myelogenous leukaemia cell line
Clone MEM-188
Isotype IgG2a
Specificity The antibody reacts with a 180 kDa isoform of CD56 (NCAM) expressed in leukocytes. It has been suggested that the antibody could react with rhesus monkey lymphocytes. Reactivity with other NCAM isoforms has not been tested.
Cross-Reactivity (Details) Species reactivity (tested):Human, Non-Human Primates
Purification Size-Exclusion Chromatography
Alternative Name CD56
Background CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of immunoglobulin family serving as adhesive molecule which is ubiquitously expressed in nervous system, usually as 120 kDa, 140 kDa or 180 kDa isoform, and it is also found on T cells and NK cells. Polysialic modification results in reduction of CD56-mediated cell adhesion and is involved in cell migration, axonal growth, pathfinding and synaptic plasticity. CD56 is a widely used neuroendocrine marker with a high sensitivity for neuroendocrine tumours and ovarian granulosa cell tumours.Synonyms: N-CAM-1, NCAM, NCAM-1, Neural cell adhesion molecule 1
Gene ID 4684
NCBI Accession NP_000606
UniProt P13591
Research Area CD Antigens, Surface Receptors of Immune Cells, Signaling
Application Notes Flow Cytometry: Use 10 μL to label 10^6 cells or 100 μL whole blood or blood or 10^6 cells ina suspension.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 15 mM Sodium Azide and 0.2 % (w/v) high-grade BSA (Protease free) as a stabilizing agent, 15 mM Sodium Azide, 0.2 % (w/v) high-grade BSA (Protease free)
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody prior to reconstitution at 2-8 °C. Following reconstitution store (in aliquots) at -20 °C.
Background publications Xu, Hao, Sun et al.: "2:1 multiplexing function in a simple molecular system." in: Sensors (Basel, Switzerland), Vol. 12, Issue 4, pp. 4421-30, 2012 (PubMed).

Jakovcevski, Mo, Zecevic: "Down-regulation of the axonal polysialic acid-neural cell adhesion molecule expression coincides with the onset of myelination in the human fetal forebrain." in: Neuroscience, Vol. 149, Issue 2, pp. 328-37, 2007 (PubMed).

Ohishi, Kaku, Oya et al.: "CD56 expression in ovarian granulosa cell tumors, and its diagnostic utility and pitfalls." in: Gynecologic oncology, Vol. 107, Issue 1, pp. 30-8, 2007 (PubMed).

McCluggage, McKenna, McBride: "CD56 is a sensitive and diagnostically useful immunohistochemical marker of ovarian sex cord-stromal tumors." in: International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, Vol. 26, Issue 3, pp. 322-7, 2007 (PubMed).

Yates, Rovis, Mitchell et al.: "The maintenance of human CD4+ CD25+ regulatory T cell function: IL-2, IL-4, IL-7 and IL-15 preserve optimal suppressive potency in vitro." in: International immunology, Vol. 19, Issue 6, pp. 785-99, 2007 (PubMed).

Drbal, Moertelmaier, Holzhauser et al.: "Single-molecule microscopy reveals heterogeneous dynamics of lipid raft components upon TCR engagement." in: International immunology, Vol. 19, Issue 5, pp. 675-84, 2007 (PubMed).

Lin, Liu, Chen et al.: "CD94 1A transcripts characterize lymphoblastic lymphoma/leukemia of immature natural killer cell origin with distinct clinical features." in: Blood, Vol. 106, Issue 10, pp. 3567-74, 2005 (PubMed).

Brdicková, Brdicka, Angelisová et al.: "LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling." in: The Journal of experimental medicine, Vol. 198, Issue 10, pp. 1453-62, 2003 (PubMed).

Brdicka, Imrich, Angelisová et al.: "Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling." in: The Journal of experimental medicine, Vol. 196, Issue 12, pp. 1617-26, 2002 (PubMed).

Lanier, Chang, Azuma et al.: "Molecular and functional analysis of human natural killer cell-associated neural cell adhesion molecule (N-CAM/CD56)." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 146, Issue 12, pp. 4421-6, 1991 (PubMed).

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