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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Keratin 13 (KRT13) antibody
|Synonyms||K13, CK13, MGC3781, MGC161462, Krt1-13, Krt-1.13, Ka13, k13, ck13, MGC84388, MGC115054, krt13, KRT15|
Cow (Bovine), Human, Rat (Rattus)
Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
|4 references available|
|Quantity||50 µg (Variants)|
|Price||396.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 6 to 8 Business Days|
|Alternative name||Cytokeratin 13|
|Immunogen||Keratin K13 of Mr 54. 000 purified from human esophagus.|
|Cross-Reactivity||Cow (Bovine), Human, Rat (Rattus)|
|Description||Cytokeratin 13 is a member of the keratin gene family. The keratins are intermediatefilament proteins responsible for the structural integrity of epithelial cells and aresubdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist ofacidic proteins which are arranged in pairs of heterotypic keratin chains. This type Icytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornifiedstratified epithelia. Mutations in this gene and keratin 4 have been associated with theautosomal dominant disorder White Sponge Nevus.|
|Characteristics||Synonyms: CK-13, CK13, Keratin-13, KRT13, K13, KRT-13, Keratin type I cytoskeletal 13|
|Application Notes||Immunofluorescence. Immunohistochemistry on frozen and paraffin sections: 1: 10, protease pretreatmentimproves the performance of this excellent marker in immunohisto-chemistry: 1/10 withPBS, pH 7.4. Western Blot. Incubation time: 1h at RT, extended with parafin. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.|
|Buffer||Contains 0.09 % sodium azide, 0.5% BSA in PBS buffer, pH 7.4Reconstitution: Restore in 1 ml dist. water.|
|Storage||Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.|
|Research Area||Signaling, Cytoskeleton, Extracellular Matrix|
|Restrictions||For Research Use only|
Dallenbach-Hellweg, Lang: "Immunohistochemical studies on uterine tumors. I. Invasive squamous cell carcinomas of the cervix and their precursors." in: Pathology, research and practice, Vol. 187, Issue 1, pp. 36-43, 1991 (PubMed).
Moll, Achtstaetter, Becht et al.: "Cytokeratins in normal and malignant transitional epithelium. Maintenance of expression of urothelial differentiation features in transitional cell carcinomas and bladder carcinoma cell culture lines." in: The American journal of pathology, Vol. 132, Issue 1, pp. 123-44, 1988 (PubMed).
Moll, Franke, Schiller et al.: "The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells." in: Cell, Vol. 31, Issue 1, pp. 11-24, 1983 (PubMed).
Demirkesen, Hoede, Moll: "Epithelial markers and differentiation in adnexal neoplasms of the skin: an immunohistochemical study including individual cytokeratins." in: Journal of cutaneous pathology, Vol. 22, Issue 6, pp. 518-35, 1996 (PubMed).
|Hosts||Mouse (39), Rabbit (24), Goat (5), Guinea Pig (2)|
|Reactivities||Human (63), Rat (Rattus) (19), Mouse (Murine) (13), Cow (Bovine) (5), Cat (Feline) (4), Rabbit (3), Chicken (2), Dog (Canine) (2), Pig (Porcine) (2), Zebrafish (Danio rerio) (2), Xenopus laevis (1), Zebrafish (1)|
|Applications||Western Blotting (WB) (57), Immunohistochemistry (IHC) (30), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (23), ELISA (22), Immunofluorescence (IF) (18), Immunohistochemistry (Fixed) (IHC (fx)) (9), Immunohistochemistry (Frozen Sections) (IHC (fro)) (8), Immunocytochemistry (ICC) (7), Immunoprecipitation (IP) (5), Flow Cytometry (FACS) (4)|
|Epitopes||C-Term (3), Internal Region (3), N-Term (3), AA 143-295 (1), Isoform A,C-Term (1), N-Term,AA 115-144 (1)|