Low Density Lipoprotein Receptor (LDLR) (Extracellular Domain), (AA 184-195) antibody

Details for Product No. ABIN113461
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Antigen
Synonyms FH, FHC, LDLCQ2, Hlb301, LDLRA
Epitope
Extracellular Domain, AA 184-195
(8), (6), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(77), (36), (26), (22), (12), (12), (12), (8), (2), (1)
Host
Rabbit
(57), (21), (9), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(14), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB), Flow Cytometry (FACS)
(71), (32), (31), (14), (14), (13), (13), (10), (7), (6), (4), (2)
Pubmed 2 references available
Catalog no. ABIN113461
Quantity 0.25 mL
Price
478.50 $   Plus shipping costs $45.00
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Immunogen Specific synthetic peptide (sequence not conserved in VLDL receptor and LRP) of the LDL receptor extracellular domain (epitope between residues 184-195, the linker region between repeats 4 and 5)
Specificity The antibody reacts specifically with The LDL Receptor (160 kD mature or glycosylated receptor, 120 kD precursor or unglycosylated receptor) plays a key role in cellular cholesterol homeostasis. It does not inhibit binding of LDL.
Purification Immunoaffinity Chromatography
Alternative Name LDLR
Background The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia
Alternate names: LDL receptor, LDLR, Low-density lipoprotein receptor
Gene ID 3949
NCBI Accession NP_000518.1
UniProt P01130
Application Notes Flow Cytometry: 1/10. Immunobloting: 1/100-1/200. Recognizes the 160 kDa band of LDLR and a 120 kDa band ofthe LDLR precursor from Fibroblasts, Hepatocytes, and monocytic cells cultured in thepresence of lipoprotein-deficient serum. Immunohistochemistry: 1/20. Receptor Binding Studies. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.1 mg/mL
Buffer PBS 0.5% BSA
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the lyophilized antibody at -20°C. Following reconstitution, the product ist stable at 2-8°C for up one week or (in aliquots) at -20°C for up to six months.
Expiry Date 12 months
Product cited in: Akazawa, Date, Morikawa et al.: "CD81 expression is important for the permissiveness of Huh7 cell clones for heterogeneous hepatitis C virus infection." in: Journal of virology, Vol. 81, Issue 10, pp. 5036-45, 2007 (PubMed).

Background publications Eden, Patel, Sun et al.: "Restoration of LDL receptor function in cells from patients with autosomal recessive hypercholesterolemia by retroviral expression of ARH1." in: The Journal of clinical investigation, Vol. 110, Issue 11, pp. 1695-702, 2002 (PubMed).

Hosts (57), (21), (9), (2)
Reactivities (77), (36), (26), (22), (12), (12), (12), (8), (2), (1)
Applications (71), (32), (31), (14), (14), (13), (13), (10), (7), (6), (4), (2)
Conjugates (14), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (8), (6), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1)
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