LDLR antibody (C-Term)

Catalog No. ABIN7268296

This Rabbit Polyclonal antibody specifically detects LDLR in WB, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for LDLR antibody (C-Term) (ABIN7268296)

Target: LDLR (Low Density Lipoprotein Receptor (LDLR))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LDLR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Grade: KO Validated

Product Details anti-LDLR Antibody

Binding Specificity: C-Term

Purpose: [KO Validated] LDL Receptor (LDLR) Rabbit pAb

Sequence: VFLCLGVFLL WKNWRLKNIN SINFDNPVYQ KTTEDEVHIC HNQDGYSYPS RQMVSLEDDV A

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 800 to the C-terminus of human LDL Receptor (LDLR) (NP_000518.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for LDLR

Target: LDLR (Low Density Lipoprotein Receptor (LDLR))

Alternative Name: LDLR

Background: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.,LDLR,FH,FHC,LDLCQ2,Cancer,Signal Transduction,Endocrine & Metabolism,Lipid Metabolism,Cholesterol Metabolism,Cardiovascular,Heart,Lipids,Cardiovascular diseases,Heart disease,LDLR

Molecular Weight: 75kDa/76kDa/82kDa/90kDa/95kDa

Gene ID: 3949

UniProt: P01130

Pathways: Hepatitis C, Lipid Metabolism