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Pancreatic Polypeptide (PPY) antibody

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Synonyms PPY, PNP, PP, AV061413, IGSPP
(67), (29), (24), (7), (5), (3), (2), (1)
(58), (22), (11)
(4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(44), (25), (21), (21), (11), (10), (4), (4), (3), (2), (1), (1), (1), (1), (1), (1)
Pubmed 4 references available
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Quantity 1 mL
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Immunogen Synthetic Human Pancreatic Polypeptide conjugated to Keyhole Limpet Hemocyanin.
Specificity This antibody reacts with Pancreatic Polypeptide. It stains the periphery of islets, exocrine pancreatic parenchyma, and the epithelium of small and medium sized ducts and acinar cells.
Cellular Localization: Cytoplasmic.
Purification Purified
Alternative Name Pancreatic Prohormone (PPY Antibody Abstract)
Background Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma levels of this hormone have been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain.Synonyms: Obinepitide, PNP, PPY, Pancreatic polypeptide
Gene ID 5539
NCBI Accession NP_002713
UniProt P01298
Application Notes Immunohistochemistry on Frozen and Paraffin Embedded Sections: diluted of 1/25-1/50 inan ABC method (30 minutes at room temperature)Recommended Positive Control: Pancreas.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one mounth or (in aliquots) at -20 °C for longer.
Background publications Nurse, Bissett: "Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast." in: Nature, Vol. 292, Issue 5823, pp. 558-60, 1981 (PubMed).

Matsushime, Roussel, Ashmun et al.: "Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle." in: Cell, Vol. 65, Issue 4, pp. 701-13, 1991 (PubMed).

Meyerson, Enders, Wu et al.: "A family of human cdc2-related protein kinases." in: The EMBO journal, Vol. 11, Issue 8, pp. 2909-17, 1992 (PubMed).

Xiong, Zhang, Beach: "D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA." in: Cell, Vol. 71, Issue 3, pp. 505-14, 1992 (PubMed).

Catalog No. ABIN115336
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