PPY antibody (AA 1-95)

Catalog No. ABIN1098139

Product Details anti-PPY Antibody

Target: PPY (Pancreatic Polypeptide (PPY))

Binding Specificity: AA 1-95

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PPY antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Purification: purified

Immunogen: Purified recombinant fragment of human PPY (AA: 1-95) expressed in E. coli.

Clone: 2G5D12

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000, FCM: 1:200 - 1:400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

References for anti-PPY antibody (ABIN1098139)

Banerjee, Onyuksel: "Human pancreatic polypeptide in a phospholipid-based micellar formulation." in: Pharmaceutical research, Vol. 29, Issue 6, pp. 1698-711, (2012) (PubMed).

Naessén, Carlström, Holst, Hellström, Hirschberg: "Women with bulimia nervosa exhibit attenuated secretion of glucagon-like peptide 1, pancreatic polypeptide, and insulin in response to a meal." in: The American journal of clinical nutrition, Vol. 94, Issue 4, pp. 967-72, (2011) (PubMed).

Target Details for PPY

Target: PPY (Pancreatic Polypeptide (PPY))

Alternative Name: PPY (PPY Products)

Synonyms: PPY antibody, PNP antibody, PP antibody, AV061413 antibody, IGSPP antibody, pancreatic polypeptide antibody, peptide YY antibody, PPY antibody, Ppy antibody, PYY antibody

Background:

Description: This gene belongs to the NPY family and it encodes a protein that is synthesized as a 95 aa polypeptide precursor in the pancreatic islets of Langerhans. It is cleaved into two peptide products, the active hormone of 36 aa and an icosapeptide of unknown function. The hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain. , , , ,

Aliases: PNP

Molecular Weight: 10.4 kDa

Gene ID: 5539

HGNC: 5539

Pathways: Feeding Behaviour