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Details for Product No. ABIN115447

AMACR / RACE antibody

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Antigen
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 3 references available
Catalog no. ABIN115447
Quantity 1 mL
Price
511.50 $   Plus shipping costs $45.00
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anti-AMACR / RACE antibody

Product details

Target Details Application Details Handling Images References Alternatives back to top
Immunogen A synthetic human AMACR peptide.
Specificity Reacts to P504S Alpha-Methylacyl-CoA Racemace. Cellular Localization: Cytoplasmic.
Purification Purified

Target Details

Application Details Handling Images References Alternatives back to top
Background P504S (AMARC) has been recently described as prostate cancer-specific gene that encodes a protein involved in the beta-oxidation of branched chain fatty acids. Expression of P504S protein is found in prostatic adenocarcinoma but not in benign prostatic tissue. It stains premalignant lesions of prostate: high-grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia. P504S can be used as a positive marker for PIN.
Alternate names: 2-methylacyl-CoA racemase, Alpha-methylacyl-CoA racemase, P504S
Gene ID 23600
NCBI Accession NP_055139.4
UniProt Q9UHK6

Application Details

Target Details Handling Images References Alternatives back to top
Application Notes Immunohistochemistry on Formalin-Fixed Paraffin Embedded Sections: 1/25-1/50 in anABC method (30 minutes at room temperature). Formalin fixed paraffin embedded tissue sections require high temperature antigenunmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining. Recommended Positive Control: Prostate carcinoma. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Target Details Application Details Images References Alternatives back to top
Format Liquid
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months

References

Target Details Application Details Handling Images Alternatives back to top
Background publications Beach, Gown, De Peralta-Venturina et al.: "P504S immunohistochemical detection in 405 prostatic specimens including 376 18-gauge needle biopsies." in: The American journal of surgical pathology, Vol. 26, Issue 12, pp. 1588-96, 2002 (PubMed).

Douglas, Shi, Sang: "Computational sequence analysis of the tissue inhibitor of metalloproteinase family." in: Journal of protein chemistry, Vol. 16, Issue 4, pp. 237-55, 1997 (PubMed).

Liu, Wang, Greene et al.: "Preparation and characterization of recombinant tissue inhibitor of metalloproteinase 4 (TIMP-4)." in: The Journal of biological chemistry, Vol. 272, Issue 33, pp. 20479-83, 1997 (PubMed).

Alternatives

Target Details Application Details Handling Images References back to top
Alternatives for antigen "AMACR / RACE", type "Antibodies"
Hosts (7), (2)
Reactivities (10), (3), (2)
Applications (6), (5), (4), (2), (2), (1), (1), (1)
Epitopes (2), (1), (1), (1)
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