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AMACR / RACE antibody

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Antigen
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 3 references available
Catalog no. ABIN115447
Quantity 1 mL  (Variants)
Price
511.50 $   Plus shipping costs $45.00
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anti-AMACR / RACE antibody

Product details

Target Details Application Details Handling Images References Alternatives Variants back to top
Immunogen A synthetic human AMACR peptide.
Specificity Reacts to P504S Alpha-Methylacyl-CoA Racemace. Cellular Localization: Cytoplasmic.
Purification Purified

Target Details

Application Details Handling Images References Alternatives Variants back to top
Background P504S (AMARC) has been recently described as prostate cancer-specific gene that encodes a protein involved in the beta-oxidation of branched chain fatty acids. Expression of P504S protein is found in prostatic adenocarcinoma but not in benign prostatic tissue. It stains premalignant lesions of prostate: high-grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia. P504S can be used as a positive marker for PIN.
Alternate names: 2-methylacyl-CoA racemase, Alpha-methylacyl-CoA racemase, P504S
Gene ID 23600
NCBI Accession NP_055139.4
UniProt Q9UHK6

Application Details

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Application Notes Immunohistochemistry on Formalin-Fixed Paraffin Embedded Sections: 1/25-1/50 in anABC method (30 minutes at room temperature). Formalin fixed paraffin embedded tissue sections require high temperature antigenunmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining. Recommended Positive Control: Prostate carcinoma. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

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Format Liquid
Handling Advice Avoid repeated freezing and thawing.
Storage 2-8 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months

References

Target Details Application Details Handling Images Alternatives Variants back to top
Background publications Beach, Gown, De Peralta-Venturina et al.: "P504S immunohistochemical detection in 405 prostatic specimens including 376 18-gauge needle biopsies." in: The American journal of surgical pathology, Vol. 26, Issue 12, pp. 1588-96, 2002 (PubMed).

Douglas, Shi, Sang: "Computational sequence analysis of the tissue inhibitor of metalloproteinase family." in: Journal of protein chemistry, Vol. 16, Issue 4, pp. 237-55, 1997 (PubMed).

Liu, Wang, Greene et al.: "Preparation and characterization of recombinant tissue inhibitor of metalloproteinase 4 (TIMP-4)." in: The Journal of biological chemistry, Vol. 272, Issue 33, pp. 20479-83, 1997 (PubMed).

Alternatives

Target Details Application Details Handling Images References Variants back to top
Alternatives for antigen "AMACR / RACE", type "Antibodies"
Hosts (6), (1)
Reactivities (8), (3), (2)
Applications (5), (4), (3), (2), (2), (1), (1), (1)
Epitopes (1), (1), (1)
Beacon
Guglhupf
Guglhupf Guglhupf Guglhupf