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NFKB2 antibody (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (p49/p100)) (N-Term)

Details for Product anti-NFKB2 Antibody No. ABIN116523, Supplier: Login to see New
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Synonyms NF-kappaB2, lyt, p49, p49/p100, p50B, p52
(17), (17), (14), (13), (9), (6), (5), (5), (5), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(135), (63), (37), (2), (2), (2), (1), (1)
(141), (10)
This NFKB2 antibody is un-conjugated
(7), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Immunoprecipitation (IP), Western Blotting (WB)
(118), (47), (38), (35), (30), (22), (12), (11), (5), (4), (3), (1), (1), (1), (1)
Pubmed 2 references available
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Quantity 0.1 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Human NFkB p52/p100 peptide corresponding to a region near the N-terminus of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).
Specificity Anti-Human NFKB2 p52 may react non-specifically with other proteins. Control peptide (R1011CP) will compete only with the specific reaction of antiserum with Human NFKB2 p52.
Purification Prepared from monospecific antiserum by delipidation and defibrination.
Alternative Name NFKB2 / NF-kappa-B p100/p52 (NFKB2 Antibody Abstract)
Background NFκB was originally identified as a factor that binds to the immunoglobulin kappa light chain enhancer in B cells. It was subsequently found in non-B cells in an inactive cytoplasmic form consisting of NFκB bound to IκB. NFκB was originally identified as a heterodimeric DNA binding protein complex consisting of p65 (RelA) and p50 (NFKB1) subunits. Other identified subunits include p52 (NFKB2), c-Rel, and RelB. The p65, cRel, and RelB subunits are responsible for transactivation. The p50 and p52 subunits possess DNA binding activity but limited ability to transactivate. p52 has been reported to form transcriptionally active heterodimers with the NFκB subunit p65, similar to p50/p65 heterodimers. The heterodimers of p52/p65 and p50/p65 are regulated by physical inactivation in the cytoplasm by an inhibitor called IκB-α. IκB-α binds to the p65 subunit, preventing nuclear localization and DNA binding. Low levels of p52 and p50 homodimers can also exist in cells.Synonyms: DNA-binding factor KBF2, H2TF1, KBF2, LYT10, Lymphocyte translocation chromosome 10, NF kappa B, NF-kB p100, NF-kB p52, Nuclear factor NF-kappa-B p100 subunit, Oncogene Lyt-10
Gene ID 4791
NCBI Accession NP_001070961
UniProt Q00653
Application Notes Suitable for Western blotting (1/1000), Immunoprecipitation and ELISA. Use control peptide at 1 l per l of antiserum. Recommended Dilutions: This product was assayed by immunoblot and found to bereactive against Human NFKB2 p52 at a dilution of 1: 1000 followed by reaction withPeroxidase conjugated Affinity Purified anti-Rabbit IgG [H&L] (Goat). Anti-Human NFKB2p52 is suitable for the detection by immunoblot of Human NFKB2 p52 and its precursorprotein p100. Cross reactivity with p52 from other species may occur but has not beenspecifically determined. Reactivity in supershift assays has not been determined.
Restrictions For Research Use only
Format Liquid
Concentration 90.0 mg/mL (by Refractometry)
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Background publications Wang, Cui, Schroering et al.: "NF-kappa B2 p100 is a pro-apoptotic protein with anti-oncogenic function." in: Nature cell biology, Vol. 4, Issue 11, pp. 888-93, 2002 (PubMed).

Baldwin: "The NF-kappa B and I kappa B proteins: new discoveries and insights." in: Annual review of immunology, Vol. 14, Issue 8, pp. 649-83, 1996 (PubMed).

Catalog No. ABIN116523
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