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NFKB2 Antibodies

(Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (NFKB2))
NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF- kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14- activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form\; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65 (By similarity).
anti-Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (NFKB2) (AA 1-340) antibody anti-Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (NFKB2) (AA 1-340) antibody anti-Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (NFKB2) (AA 1-340) antibody (ABIN3043293)

NFKB2 Reactivity: Human, Mouse, Rat IHC (p), WB Host: Rabbit Polyclonal unconjugated

anti-Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (NFKB2) (C-Term) antibody anti-Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (NFKB2) (C-Term) antibody anti-Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (NFKB2) (C-Term) antibody (ABIN2779436)

NFKB2 Reactivity: Human, Rat, Cow, Horse, Pig, Rabbit IHC, WB Host: Rabbit Polyclonal unconjugated

anti-Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (NFKB2) (C-Term) antibody anti-Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (NFKB2) (C-Term) antibody anti-Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (NFKB2) (C-Term) antibody (ABIN2854310)

NFKB2 Reactivity: Human, Mouse IP, WB Host: Rabbit Polyclonal unconjugated

NFKB2 Antibodies by Grade

Find NFKB2 Antibodies with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

NFKB2 Antibodies by Reactivity

Find NFKB2 Antibodies for a variety of species such as anti-Human NFKB2, anti-Mouse NFKB2, anti-Rat NFKB2. The species listed below are among those available. Click on a link to go to the corresponding products.

NFKB2 Antibodies by Application

Find NFKB2 Antibodies validated for a specific application such as WB, ELISA, IHC, IF. Some of the available applications are listed below. Click on a link to go to the corresponding products.

NFKB2 Antibodies by Host

Find NFKB2 Antibodies with a specific Host. The Host listed below are among those available. Click on a link to go to the corresponding products.

NFKB2 Antibodies by Binding Specificity

Find NFKB2 Antibodies with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

NFKB2 Antibodies by Clonality

Find available monoclonal or polyclonal NFKB2 Antibodies. Click on a link to go to the corresponding products.

NFKB2 Antibodies by Clone

Find NFKB2 Antibodies with a specific Clone. The Clone listed below are among those available. Click on a link to go to the corresponding products.

NFKB2 Antibodies by Conjugate

Find NFKB2 Antibodies with a specific conjugate such as Biotin, FITC, Alexa Fluor 488. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular NFKB2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse, Rat
Application IHC (p), WB
Validations
  • (7)
  • (3)
Cat. No. ABIN3044018
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, ICC, IF, IHC, IP, WB
Validations
  • (4)
Cat. No. ABIN6256439
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, ICC, IF, IHC, IP, WB
Validations
  • (4)
Cat. No. ABIN6255542
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, IF, IHC, IP, WB
Validations
  • (3)
Cat. No. ABIN3185875
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application ELISA, FACS, ICC, IF (cc), IF (p), IHC (fro), IHC (p)
Validations
  • (3)
Cat. No. ABIN1386117
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Application IHC, WB
Validations
  • (1)
  • (2)
Cat. No. ABIN2777546
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, ICC, IF, IHC, IP, WB
Validations
  • (3)
Cat. No. ABIN6263614
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application IF, IHC (p), WB
Validations
  • (3)
Cat. No. ABIN197572
Quantity 0.1 mL
Datasheet Datasheet
Reactivity Chicken, Cow, Human, Mouse, Pig, Rat
Application IC, IF, IP, IHC, WB
Validations
  • (3)
Cat. No. ABIN2705037
Quantity 200 μL
Datasheet Datasheet
Reactivity Cow, Horse, Human
Application IHC, IHC (p), WB
Validations
  • (3)
Cat. No. ABIN6735824
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, IHC, IP, WB
Validations
  • (2)
Cat. No. ABIN1531919
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, IHC, IP, WB
Validations
  • (2)
Cat. No. ABIN1532950
Quantity 100 μg
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application WB
Validations
  • (2)
Cat. No. ABIN2777184
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application ELISA, ICC, IF, WB
Validations
  • (2)
Cat. No. ABIN6255544
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (2)
Cat. No. ABIN3032044
Quantity 0.4 mL
Datasheet Datasheet

Latest Publications for our NFKB2 Antibodies

Li, Xiao, Li, Li, Zeng, Liu, Liang, Li, Chu, Yang: "Hydrogen sulfide reduced renal tissue fibrosis by regulating autophagy in diabetic rats." in: Molecular medicine reports, Vol. 16, Issue 2, pp. 1715-1722, (2018) (PubMed).

Sun, Xue, Xue, Ren, Wu, Wang: "Acetylpuerarin protects against OGD-induced cell injury in BV2 microglia by inhibiting HMGB1 release." in: Die Pharmazie, Vol. 73, Issue 2, pp. 92-97, (2018) (PubMed).

Liu, Jia, Chong, Jiang, Yang, Li, Ma, Sun, Zhou: "Effects of oral cimetidine on the reproductive system of male rats." in: Experimental and therapeutic medicine, Vol. 15, Issue 6, pp. 4643-4650, (2018) (PubMed).

Yu, Wang, He, Wang, Gao, Ren, Shi et al.: "Curcumin exerts anti-inflammatory and antioxidative properties in 1-methyl-4-phenylpyridinium ion (MPP(+))-stimulated mesencephalic astrocytes by interference with TLR4 and downstream signaling ..." in: Cell stress & chaperones, Vol. 21, Issue 4, pp. 697-705, (2017) (PubMed).

Yao, Lu, Shi, Xu, Cai: "Neuroprotective effect of combining tanshinone IIA with low-dose methylprednisolone following acute spinal cord injury in rats." in: Experimental and therapeutic medicine, Vol. 13, Issue 5, pp. 2193-2202, (2017) (PubMed).

Suen, Uddin, Prow, Bowen, Hall, Bielefeldt-Ohmann: "Tissue-specific transcription profile of cytokine and chemokine genes associated with flavivirus control and non-lethal neuropathogenesis in rabbits." in: Virology, Vol. 494, pp. 1-14, (2016) (PubMed).

Kan, Zhou, Jin, Yang: "Effects of PDTC on NF-?B expression and apoptosis in rats with severe acute pancreatitis-associated lung injury." in: International journal of clinical and experimental medicine, Vol. 8, Issue 3, pp. 3258-70, (2015) (PubMed).

Wang, Wang, Fang, Zhou, Liu, Su: "High glucose induces and activates Toll-like receptor 4 in endothelial cells of diabetic retinopathy." in: Diabetology & metabolic syndrome, Vol. 7, pp. 89, (2015) (PubMed).

Yang, Wang, Wang, Xu, He, Wen, Yan, Su, Zhu: "Toll-like receptor 4 prompts human breast cancer cells invasiveness via lipopolysaccharide stimulation and is overexpressed in patients with lymph node metastasis." in: PLoS ONE, Vol. 9, Issue 10, pp. e109980, (2014) (PubMed).

Chang, Al-Alwan, Risse, Halayko, Martin, Baglole, Eidelman, Hamid: "Th17-associated cytokines promote human airway smooth muscle cell proliferation." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 26, Issue 12, pp. 5152-60, (2012) (PubMed).

Aliases for NFKB2 Antibodies

nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 (Nfkb2) Antibodies
lyt Antibodies
NF-kappaB2 Antibodies
p49 Antibodies
p49/p100 Antibodies
p50B Antibodies
p52 Antibodies
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