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Details for Product No. ABIN117945

Cullin-Associated and Neddylation-Dissociated 1 (CAND1) (C-Term), (AA 1130-1143) antibody

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TIP120, TIP120A, Tip120, Tip120A, fb78a05, zgc:55729, wu:fb78a05, tip120, tip120a, 2310038O07Rik, 6330512O03Rik, AI195005, AI846556, D10Ertd516e, Tp120a, mKIAA0829, ATCAND1, CULLIN-ASSOCIATED AND NEDD ... show more
»Alternatives C-Term, AA 1130-1143
»Alternatives Human, Mouse (Murine), Rat (Rattus)
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives ELISA, Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 9 references available
Catalog no. ABIN117945
Quantity 0.1 mL
379.50 $   Plus shipping costs $45.00
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Immunogen This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 1130-1143 of Human CAND2/TIP120B (C-terminal) coupled to KLH.
Sequence Human CAND2 (TIP120B) (1143 aa 125.4 kDa): 1 mstaafhiss llekmtssdk dfrfmatsdl mselqkdsiq ldedserkvv kmllrlledk 61 ngevqnlavk wlgvplgafh asllhcllpq lssprlavrk ravgalghla aacstdlfve 121 ladhlldrlp gprvptspta irtliqclgs vgrqaghrlg ahldrlvplv edfcnlddde 181 lresclqafe aflrkcpkem gphvpnvtsl clqyikhdpn ynydsdedee qmetedsefs 241 eqesedeysd dddmswkvrr aaakciaali ssrpdllpdf hctlapvlir rfkereenvk --- 901 vkflisdqph pidpllksfi gefmeslqdp dlnvrratla ffnsavhnkp slvrdllddi 961 lpllyqetki rrdlirevem gpfkhtvddg ldvrkaafec mysllesclg qldiceflnh 1021 vedglkdhyd irmltfimva rlatlcpapv lqrvdrliep lratctakvk agsvkqefek 1081 qdelkrsamr avaalltipe vgkspimadf ssqirsnpel aalfesiqkd sasapstdsm 1141 els
Specificity This antibody is monospecific antiserum processed by delipidation and defibrination followed by sterile filtration. It reacts with human, rat and mouse CAND2/TIP120B. Cross reactivity does occur with human, rat and mouse CAND1/TIP120A. Cross reactivity with CAND2 from other sources is not known.
Purification Delipidation and defibrination.
Alternative Name CAND1
Background CAND2 is also known as TIP120B, and TATA-binding protein-interacting protein 120B. While both CAND1 (TIP120A) and CAND2 (TIP120B) are TATA-binding proteins and form complexes with various nuclear proteins involved in the control of eukaryotic gene transcription, CAND2 (TIP120B) is expressed specifically in muscle and heart tissue. This is contrary to the ubiquitous expression of CAND1 (TIP120A). TIP120 homologs exist in various higher eukaryotes including D. melanogaster, C. elegans, and A. thaliana. TIP120B is 60% identical in amino acid sequence to TIP120A.
Alternate names: Cullin-associated NEDD8-dissociated protein 1, Cullin-associated and neddylation- dissociated protein 1, KIAA0829, TBP-interacting protein TIP120A, TBP-interacting protein of 120 kDa A, TIP120, TIP120A, p120 CAND1
Gene ID 55832
NCBI Accession NP_060918.2
UniProt Q86VP6
Research Area Apoptosis/Necrosis, Proteasome
Application Notes Western blot (1: 500-1: 1,000). Immunoprecipitation: The antibody immunoprecipitates in vitro translated protein andprotein from transfected cell lysates (using HeLa and NIH-3T3, and others). Coimmunoprecipitation of related proteins has not been tested. A 125.4 kDa bandcorresponding to human CAND2 is detected. CAND2 is specifically expressed in muscle
Restrictions For Research Use only
Format Liquid
Concentration 85 mg/mL (by Refractometry)
Handling Advice Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Makino, Yoshida, Yogosawa et al.: "Multiple mammalian proteasomal ATPases, but not proteasome itself, are associated with TATA-binding protein and a novel transcriptional activator, TIP120." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 4, Issue 9, pp. 529-39, 1999 (PubMed).

Makino, Yogosawa, Kayukawa et al.: "TATA-Binding protein-interacting protein 120, TIP120, stimulates three classes of eukaryotic transcription via a unique mechanism." in: Molecular and cellular biology, Vol. 19, Issue 12, pp. 7951-60, 2000 (PubMed).

Jentsch, Pyrowolakis: "Ubiquitin and its kin: how close are the family ties?" in: Trends in cell biology, Vol. 10, Issue 8, pp. 335-42, 2000 (PubMed).

Liu, Furukawa, Matsumoto et al.: "NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases." in: Molecular cell, Vol. 10, Issue 6, pp. 1511-8, 2002 (PubMed).

Zheng, Yang, Harrell et al.: "CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex." in: Molecular cell, Vol. 10, Issue 6, pp. 1519-26, 2002 (PubMed).

Oshikawa, Matsumoto, Yada et al.: "Preferential interaction of TIP120A with Cul1 that is not modified by NEDD8 and not associated with Skp1." in: Biochemical and biophysical research communications, Vol. 303, Issue 4, pp. 1209-16, 2003 (PubMed).

Cheng, Dai, Zhao: "AtCAND1, a HEAT-repeat protein that participates in auxin signaling in Arabidopsis." in: Plant physiology, Vol. 135, Issue 2, pp. 1020-6, 2004 (PubMed).

Feng, Shen, Sullivan et al.: "Arabidopsis CAND1, an unmodified CUL1-interacting protein, is involved in multiple developmental pathways controlled by ubiquitin/proteasome-mediated protein Degradation." in: The Plant cell, Vol. 16, Issue 7, pp. 1870-82, 2004 (PubMed).

Concejero, Chen, Wang et al.: "Living donor liver transplantation for hepatocellular carcinoma: a single-center experience in Taiwan." in: Transplantation, Vol. 85, Issue 3, pp. 398-406, 2008 (PubMed).

Alternatives for antigen "Cullin-Associated and Neddylation-Dissociated 1 (CAND1)", type "Antibodies"
Hosts (12), (10)
Reactivities (21), (11), (11), (2), (2), (2), (2)
Applications (22), (16), (8), (8), (5), (1), (1)
Epitopes (9), (6), (2), (1), (1), (1)