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Alanyl (Membrane) Aminopeptidase (ANPEP) antibody

Details for Product No. ABIN118526
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Antigen
Synonyms Apn, pepN, SC8E4A.13, APN, CD13, GP150, LAP1, P150, PEPN, AP-M, AP-N, Cd13, Apm, KZP, Lap1, rAPN, APDE, p150
Reactivity
Human, Primate
(176), (51), (7), (6), (6), (6), (3), (1)
Host
Mouse
(151), (47), (33), (1), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(40), (21), (16), (11), (9), (2), (2), (2), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), ELISA, Functional Studies (Func), Immunoprecipitation (IP), Flow Cytometry (FACS)
(174), (50), (44), (37), (30), (28), (24), (13), (4), (3), (3), (1), (1), (1)
Pubmed 6 references available
Quantity 0.1 mg
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Catalog No. ABIN118526
308.00 $
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Immunogen Human AML cells.
Clone WM15
Isotype IgG1
Specificity The antibody recognises the Human CD13 cell surface glycoprotein, a 150 kD molecule expressed by granulocytes and monocytes, and by myeloid leukaemia cells.
Purification Affinity Chromatography on Protein G
Alternative Name CD13
Background CD13 is a 150 kDa type II transmembrane zinc-binding ectopeptidase expressed on various cell types. This metalloprotease preferentially catalyzes removal of neutral amino acids from small peptides, thus activating or inactivating bioactive peptides. CD13 has also role in extracellular matrix degradation, antigen processing and signal transduction, is important in inflammatory responses, regulates intercellular contact, cell motility and vascularization. CD13 is involved in protection of leukemic cells against apoptosis and its expression associated with poor prognosis of carcinomas. CD13 functions as an aminopeptidase enzyme and is also a receptor for coronavirus.
Alternate names: ANPEP, APN, Alanyl aminopeptidase, Aminopeptidase M, Aminopeptidase N, Microsomal aminopeptidase, Myeloid plasma membrane glycoprotein CD13, PEPN, gp150
Gene ID 290
NCBI Accession NP_001141.2
UniProt P15144
Research Area Stem Cells, Hematopoietic Progenitors, CD Antigens, Surface Receptors of Immune Cells, Extracellular Matrix, Signaling
Application Notes Flow Cytometry. Immunoprecipitation. Immunohistochemistry (frozen sections). ELISA. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: Clone WM15 inhibits infection of cells by human coronavirus and inhibits aminopeptidase N activity of the CD13 molecule immunoprecipitates.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, pH~7.4 containing 15 mM Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Bradstock, Favaloro, Kabral et al.: "Myeloid progenitor surface antigen identified by monoclonal antibody." in: British journal of haematology, Vol. 61, Issue 1, pp. 11-20, 1985 (PubMed).

Favaloro, Browning, Facey: "CD13 (GP150; aminopeptidase-N): predominant functional activity in blood is localized to plasma and is not cell-surface associated." in: Experimental hematology, Vol. 21, Issue 13, pp. 1695-701, 1993 (PubMed).

Tokuhara, Hattori, Ishida et al.: "Clinical significance of aminopeptidase N in non-small cell lung cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 12, Issue 13, pp. 3971-8, 2006 (PubMed).

Petrovic, Schacke, Gahagan et al.: "CD13/APN regulates endothelial invasion and filopodia formation." in: Blood, Vol. 110, Issue 1, pp. 142-50, 2007 (PubMed).

Terauchi, Kajiyama, Shibata et al.: "Inhibition of APN/CD13 leads to suppressed progressive potential in ovarian carcinoma cells." in: BMC cancer, Vol. 7, pp. 140, 2007 (PubMed).

General Tavernier, Boiron, Huguet et al.: "Outcome of treatment after first relapse in adults with acute lymphoblastic leukemia initially treated by the LALA-94 trial." in: Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, Vol. 21, Issue 9, pp. 1907-14, 2007 (PubMed).

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