CD72 Molecule (CD72) antibody

Details for Product No. ABIN118793
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Antigen
Synonyms CD72c, Ly-19, Ly-32, Ly-m19, Lyb-2, CD72b, LYB2
Reactivity
Human
(79), (32), (1)
Host
Mouse
(83), (28), (1), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(22), (14), (13), (1), (1), (1)
Application
Flow Cytometry (FACS), Immunoprecipitation (IP)
(71), (32), (22), (21), (11), (6), (5), (3), (2), (2), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN118793
308.00 $
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Immunogen Normal human lymphocytes from a lymph node
Clone 3F3
Isotype IgG2b
Specificity The antibody reacts with CD72, a 39-43 kDa type II membrane glycoprotein (C-type lectin family).
Purification Precipitation methods and ion exchange chromatography
Purity > 95 % (by SDS-PAGE)
Alternative Name CD72
Background CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation. CD72 is a pan-B cell marker expressed throughout the B lymphocytes diferentiation with the exception of plasma cells, it is also present on follicular dendritic cells.Synonyms: B-Cell marker, B-cell differentiation antigen CD72, Ly-32, Ly32, Lyb-2, Lymphocyte antigen 32
Gene ID 971
NCBI Accession NP_001773
UniProt P21854
Research Area Stem Cells, Hematopoietic Progenitors, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Application Notes Immunoprecipitation. Flow Cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing. Dilute only prior to immediate use
Storage 4 °C/-20 °C
Storage Comment Store the antibody (undiluted) at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Kumanogoh, Watanabe, Lee et al.: "Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling." in: Immunity, Vol. 13, Issue 5, pp. 621-31, 2001 (PubMed).

Kumanogoh, Kikutani: "The CD100-CD72 interaction: a novel mechanism of immune regulation." in: Trends in immunology, Vol. 22, Issue 12, pp. 670-6, 2001 (PubMed).

Kumanogoh, Shikina, Watanabe et al.: "Requirement for CD100-CD72 interactions in fine-tuning of B-cell antigen receptor signaling and homeostatic maintenance of the B-cell compartment." in: International immunology, Vol. 17, Issue 10, pp. 1277-82, 2005 (PubMed).

Mizrahi, Markel, Porgador et al.: "CD100 on NK cells enhance IFNgamma secretion and killing of target cells expressing CD72." in: PLoS ONE, Vol. 2, Issue 9, pp. e818, 2007 (PubMed).

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