Keratin 14 (KRT14) (C-Term) antibody (FITC)

Details for Product No. ABIN118964
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Antigen
Synonyms Krt14, KRT14, CK14, ouro2, EBS3, EBS4, K14, NFJ, AI626930, Krt-1.14, Krt1-14, Ka14
Epitope
C-Term
(56), (6), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(132), (27), (22), (7), (5), (3), (2)
Host
Mouse
(74), (56), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
FITC
(3), (1)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FACS)
(88), (78), (45), (31), (26), (21), (18), (16), (3), (2)
Pubmed 7 references available
Quantity 0.1 mg
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Catalog No. ABIN118964
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Immunogen Last 15 C-terminal residues of Human cytokeratin 14 conjugated to thyroglobulin.
Clone LL002
Isotype IgG3
Specificity Recognizes Cytokeratin 14, a type I intermediate filament, expressed by stratifying epithelial cells and can be used to distinguish these cell types from simple epithelial cells, which do not express Cytokeratin 14.
Purification Affinity Chromatography on Protein A
Alternative Name Cytokeratin 14
Background Keratin 14 is a member of the keratin family, the most diverse group of intermediate filaments. It is usually found as a heterotetramer with two molecules of keratin 5, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. Keratin 14 has been studied as a prognostic marker in breast cancer.
Alternate names: CK14, Cytokeratin-14, K14, KRT14, Keratin 14, Keratin Type I Cytoskeletal 14
Gene ID 3861
NCBI Accession NP_000517
UniProt P02533
Research Area Signaling, Cytoskeleton, Cytokeratins, Extracellular Matrix, Cancer
Application Notes Flow Cytometry: Use 10 ul of neat - 1/10 diluted antibody to label 10e6 cells in 100 ul (Requires Cell Permeabilisation). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.1 mg/mL
Buffer PBS with 0.09% Sodium Azide as preservative and 1% BSA as stabilizer
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Purkis, Steel, Mackenzie et al.: "Antibody markers of basal cells in complex epithelia." in: Journal of cell science, Vol. 97 ( Pt 1), pp. 39-50, 1991 (PubMed).

Lane, Alexander: "Use of keratin antibodies in tumor diagnosis." in: Seminars in cancer biology, Vol. 1, Issue 3, pp. 165-79, 1991 (PubMed).

Wetzels, Holland, van Haelst et al.: "Detection of basement membrane components and basal cell keratin 14 in noninvasive and invasive carcinomas of the breast." in: The American journal of pathology, Vol. 134, Issue 3, pp. 571-9, 1989 (PubMed).

Moll, Franke, Schiller et al.: "The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells." in: Cell, Vol. 31, Issue 1, pp. 11-24, 1983 (PubMed).

Matos, Faustino, Lopes et al.: "Detection of lymph node micrometastases in malignant mammary tumours in dogs by cytokeratin immunostaining." in: The Veterinary record, Vol. 158, Issue 18, pp. 626-30, 2006 (PubMed).

Turner, Subramanian, Thomas et al.: "Transplantation of autologous differentiated urothelium in an experimental model of composite cystoplasty." in: European urology, Vol. 59, Issue 3, pp. 447-54, 2011 (PubMed).

Abdeen, Salah, Maly et al.: "Wwox inactivation enhances mammary tumorigenesis." in: Oncogene, Vol. 30, Issue 36, pp. 3900-6, 2011 (PubMed).

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