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Keratin 19 (KRT19) antibody

Details for Product No. ABIN119586, Supplier: Login to see
Antigen
  • k19
  • ck19
  • k1cs
  • krt9
  • krt15
  • MGC76282
  • MGC83069
  • KRT19
  • CK19
  • K19
  • K1CS
  • GK-19
  • Ka19
  • Krt1-19
  • AI663979
  • EndoC
  • Krt-1.19
Reactivity
Human
520
74
51
7
7
6
4
3
3
3
2
1
1
1
Host
Mouse
326
196
18
5
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
30
18
12
6
6
6
2
2
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
363
205
202
186
96
74
63
58
54
12
9
4
3
3
2
1
1
1
1
1
1
1
1
Supplier
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Immunogen Mammary organoids
Clone BA-17
Isotype IgG1
Specificity The antibody reacts with Cytokeratin 19 (40 kDa) in Human Tissue. Cytokeratin 19 is not expressed in hepatocytes, it is often co-expressed with Cytokeratin 7.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Protein A Affinity Chromatography.
Alternative Name Cytokeratin 19 (KRT19 Antibody Abstract)
Background Cytokeratins are a subfamily of intermediate filaments and characterized by remarkable biochemical diversity. Cytokeratins are represented in epithelial tissues by at least 20 different polypeptides, molecular weight between 40 kDa and 68 kDa. The individual cytokeratin polypeptides are designated 1 to 20 and divided into the type I (acidic cytokeratins 9-20) and type II (basic to neutral cytokeratins 1-8) families.Synonyms: CK19, Cytokeratin-19, K19, KRT19, Keratin type I cytoskeletal 19, Keratin-19
Gene ID 3880
NCBI Accession NP_002267
UniProt P08727
Research Area Signaling, Cytoskeleton, Cytokeratins, Extracellular Matrix
Pathways
Application Notes Immunohistochemistry on frozen and paraffin embedded sections: 1/50 - 1/100, this product requires protein digestion pre-treatment of paraffin sections e.g. trypsin or pronase. Recommended Positive Control Tissue: Normal breast. Western blotting. Flow Cytometry. Immunoprecipitation. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline (PBS), pH ~7.4, 15 mM Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Viswaroop, B, Gopalakrishnan: "Evaluating erectile dysfunction: oral sildenafil versus intracavernosal injection of papaverine." in: The National medical journal of India, Vol. 18, Issue 6, pp. 299-301, 2006 (PubMed).

Lewis, Klimstra, Varmus: "The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer." in: Genes & development, Vol. 17, Issue 24, pp. 3127-38, 2003 (PubMed).

Bartek, Durban, Hallowes et al.: "A subclass of luminal epithelial cells in the human mammary gland, defined by antibodies to cytokeratins." in: Journal of cell science, Vol. 75, pp. 17-33, 1985 (PubMed).

Bartek, Taylor-Papadimitriou, Miller et al.: "Patterns of expression of keratin 19 as detected with monoclonal antibodies in human breast tissues and tumours." in: International journal of cancer. Journal international du cancer, Vol. 36, Issue 3, pp. 299-306, 1985 (PubMed).