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Interferon Regulatory Factor 5 (IRF5) (AA 176-240) antibody

Details for Product No. ABIN121152, Supplier: Log in to see
Antigen
  • IRF5
  • irf5
  • SLEB10
  • AW491843
  • mirf5
  • im:7155364
  • zgc:76986
Alternatives
anti-Human Interferon Regulatory Factor 5 antibody for Enzyme Immunoassay
Epitope
AA 176-240
20
12
7
4
4
4
4
3
3
3
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
99
34
24
9
4
4
2
2
2
1
1
1
Host
Mouse
56
36
16
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
95
49
24
18
18
11
7
6
6
4
2
2
2
1
Supplier
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Immunogen Recombinant human IRF-5 (176-240 aa) purified from E. coli
Clone 10T1
Isotype IgG1
Specificity The antibody recognizes Human and Mouse Interferon Regulatory Factor 5 (IRF-5). Other species not tested.
Purification Protein-G affinity chromatography
Alternative Name IRF5 (IRF5 Antibody Abstract)
Background IRF-5 is a member of IRF family, which plays a critical role in the regulation of genes induced by viral infection, immunostimulation and cell growth regulation. The expression of IRF-5 is limited to lymphoid organs, dendritic cells, and peripheral blood lymphocytes, but is not expressed in numerous leukemia and lymphoma cell lines. Three IRFs(IRF-3, IRF-5, IRF-7) function as direct transducers of virus-mediated signaling and play a critical role in the expression of type I interferon genes and some chemokines.Synonyms: IRF-5, Interferon regulatory factor 5
Gene ID 3663
UniProt Q13568
Research Area Chromatin and Nuclear Signaling, Transcription Factors, Innate Immunity, Cytokines
Pathways TLR Signaling
Application Notes ELISA. Western blot (1/500 - 1/1,000). Immunoprecipitation. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, pH 7.4, 0.09 % Sodium Azide
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-Interferon Regulatory Factor 5 (IRF5) (AA 176-240) antibody (ABIN121152) Western blot analysis The extracts of Ramos, THP-1, A20 and NIH3T3 were resolved by S...
Background publications Ning, Huye, Pagano: "Interferon regulatory factor 5 represses expression of the Epstein-Barr virus oncoprotein LMP1: braking of the IRF7/LMP1 regulatory circuit." in: Journal of virology, Vol. 79, Issue 18, pp. 11671-6, 2005 (PubMed).

Barnes, Kellum, Pinder et al.: "Interferon regulatory factor 5, a novel mediator of cell cycle arrest and cell death." in: Cancer research, Vol. 63, Issue 19, pp. 6424-31, 2003 (PubMed).

Barnes, Moore, Pitha: "Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes." in: The Journal of biological chemistry, Vol. 276, Issue 26, pp. 23382-90, 2001 (PubMed).