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Details for Product No. ABIN121152

Interferon Regulatory Factor 5 (IRF5) (AA 176-240) antibody

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Antigen
Synonyms SLEB10, mirf5, AW491843, im:7155364, zgc:76986, IRF5, irf5
Epitope
»Alternatives AA 176-240
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Application
»Alternatives ELISA, Immunoprecipitation (IP), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 3 references available
Catalog no. ABIN121152
Quantity 0.1 mL
Price
401.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Recombinant human IRF-5 (176-240 aa) purified from E. coli
Clone 10T1
Isotype IgG1
Purification Protein-G affinity chromatography
Alternative Name IRF5
Background IRF-5 is a member of IRF family, which plays a critical role in the regulation of genes induced by viral infection, immunostimulation and cell growth regulation. The expression of IRF-5 is limited to lymphoid organs, dendritic cells, and peripheral blood lymphocytes, but is not expressed in numerous leukemia and lymphoma cell lines. Three IRFs(IRF-3, IRF-5, IRF-7) function as direct transducers of virus-mediated signaling and play a critical role in the expression of type I interferon genes and some chemokines. Alternate Names: Interferon Regulatory Factor 5, IRF-5.
UniProt Q13568
Research Area Chromatin and Nuclear Signaling, Transcription Factors, Innate Immunity, Cytokines
Application Notes ELISA. Western blot (1/500 - 1/1,000). Immunoprecipitation. Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, pH 7.4 with 0.02% Thimerosal as preservative.
Preservative Thimerosal (Merthiolate)
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Barnes, Moore, Pitha: "Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes." in: The Journal of biological chemistry, Vol. 276, Issue 26, pp. 23382-90, 2001 (PubMed).

Barnes, Kellum, Pinder et al.: "Interferon regulatory factor 5, a novel mediator of cell cycle arrest and cell death." in: Cancer research, Vol. 63, Issue 19, pp. 6424-31, 2003 (PubMed).

Ning, Huye, Pagano: "Interferon regulatory factor 5 represses expression of the Epstein-Barr virus oncoprotein LMP1: braking of the IRF7/LMP1 regulatory circuit." in: Journal of virology, Vol. 79, Issue 18, pp. 11671-6, 2005 (PubMed).

Alternatives for antigen "Interferon Regulatory Factor 5 (IRF5)", type "Antibodies"
Hosts (25), (23), (11), (1)
Reactivities (60), (20), (11), (5), (2), (1), (1), (1), (1)
Applications (56), (34), (14), (12), (8), (8), (4), (3), (3), (2), (2), (2), (1), (1)
Epitopes (9), (8), (4), (3), (3), (2), (2), (2), (1)
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