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OLR1 antibody (Extracellular Domain)

OLR1 Reactivity: Human WB, IP, FACS, IHC (fro) Host: Sheep Polyclonal unconjugated
Catalog No. ABIN121884
  • Target See all OLR1 Antibodies
    OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))
    Binding Specificity
    • 16
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Extracellular Domain
    Reactivity
    • 58
    • 25
    • 22
    • 18
    • 2
    Human
    Host
    • 40
    • 22
    • 2
    • 1
    • 1
    • 1
    Sheep
    Clonality
    • 44
    • 23
    Polyclonal
    Conjugate
    • 36
    • 6
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This OLR1 antibody is un-conjugated
    Application
    • 46
    • 26
    • 22
    • 13
    • 13
    • 13
    • 10
    • 9
    • 7
    • 7
    • 6
    • 4
    • 3
    • 3
    Western Blotting (WB), Immunoprecipitation (IP), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Purification
    Affinity Chromatography
    Immunogen
    Recombinant human extracellular domain LOX-1 protein from bacteria
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    Discover our top product OLR1 Primary Antibody
  • Application Notes
    Immunohistochemistry on frozen sections. Immunoprecipitation. Flow Cytometry: 1:10, Use 10 μL of the suggested working dilution to label 10^6 cells in 100 μL. Western Blot: 1:10 - 1/100, This antibody detects intact 50 kDa LOX-1 and also a prominent 30 kDa proteolytic fragment in western blotting.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.1 mg/mL
    Buffer
    PBS, 0.09 % Sodium Azide, 1 % BSA
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
    Shelf Life: one year from despatch.
    Expiry Date
    12 months
  • Target
    OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))
    Alternative Name
    OLR1 / LOX1 (OLR1 Products)
    Synonyms
    OLR1 antibody, LOX1 antibody, Olr1 antibody, CLEC8A antibody, LOXIN antibody, SCARE1 antibody, SLOX1 antibody, LOX-1 antibody, SR-EI antibody, Scare1 antibody, Oldlr1 antibody, Oldr1 antibody, PLOX-1 antibody, oxidized low density lipoprotein receptor 1 antibody, oxidized low density lipoprotein (lectin-like) receptor 1 antibody, OLR1 antibody, Olr1 antibody
    Background
    LOX-1 is a 40-50 kDa class E scavenger receptor, expressed by endothelial cells, macrophages, activated platelets and smooth muscle cells. LOX-1 binds to a wide range of ligands, including oxidized low-density lipoprotein (oxLDL), hypochlorite modified high-density lipoprotein (HDL), aged/apoptotic cells, activated platelets and bacteria, reflecting its versatile physiological functions. Expression of the LOX-1 gene is upregulated by oxLDL and the binding of LOX-1 to oxLDL results in the activation of NF-kappaB. Furthermore, LOX-1 antibodies have been shown to suppress the oxidized HDL (oxHDL) activation of NF-KappaB in endothelial cells, suggesting that this activation may be due to the binding of oxHDL to LOX-1. Angiotensin II and the inflammatory cytokine Tumour Necrosis Factor alpha (TNFalpha) also invoke an increase in LOX-1 gene expression and studies have focused on its role in endothelial dysfunction (1,4) and inflammatory diseases such as atherosclerosis (1) and rheumatoid arthritis, as well as its affect on CD40/CD40L signaling in both atherosclerosis and human coronary artery endothelial cells (HCAECs).Synonyms: C-type lectin domain family 8 member A, CLEC8A, LOX-1, Lectin-like oxidized LDL receptor 1, Lectin-type oxidized LDL receptor 1, Ox-LDL receptor 1, Ox-LDL receptor 1 soluble form, Oxidized low-density lipoprotein receptor 1, sLOX-1, sLOX1
    UniProt
    P78380
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