Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1) (Extracellular Domain) antibody

Details for Product No. ABIN121884
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Antigen
Synonyms OLR1, LOX1, Olr1, CLEC8A, LOXIN, SCARE1, SLOX1, LOX-1, SR-EI, Scare1, Oldlr1, Oldr1, PLOX-1
Epitope
Extracellular Domain
(9), (8), (5), (4), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(84), (35), (32), (24), (12), (2)
Host
Sheep
(64), (24), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB)
(55), (36), (20), (13), (12), (3), (3), (3), (3), (3), (2), (1), (1)
Pubmed 3 references available
Quantity 50 μg
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Catalog No. ABIN121884
500.50 $
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Immunogen Recombinant human extracellular domain LOX-1 protein from bacteria
Purification Affinity Chromatography
Alternative Name OLR1 / LOX1
Background LOX-1 is a 40-50 kDa class E scavenger receptor, expressed by endothelial cells, macrophages, activated platelets and smooth muscle cells. LOX-1 binds to a wide range of ligands, including oxidized low-density lipoprotein (oxLDL), hypochlorite modified high-density lipoprotein (HDL), aged/apoptotic cells, activated platelets and bacteria, reflecting its versatile physiological functions. Expression of the LOX-1 gene is upregulated by oxLDL and the binding of LOX-1 to oxLDL results in the activation of NF-kappaB. Furthermore, LOX-1 antibodies have been shown to suppress the oxidized HDL (oxHDL) activation of NF-KappaB in endothelial cells, suggesting that this activation may be due to the binding of oxHDL to LOX-1. Angiotensin II and the inflammatory cytokine Tumour Necrosis Factor alpha (TNFalpha) also invoke an increase in LOX-1 gene expression and studies have focused on its role in endothelial dysfunction (1,4) and inflammatory diseases such as atherosclerosis (1) and rheumatoid arthritis, as well as its affect on CD40/CD40L signaling in both atherosclerosis and human coronary artery endothelial cells (HCAECs).Synonyms: C-type lectin domain family 8 member A, CLEC8A, LOX-1, Lectin-like oxidized LDL receptor 1, Lectin-type oxidized LDL receptor 1, Ox-LDL receptor 1, Ox-LDL receptor 1 soluble form, Oxidized low-density lipoprotein receptor 1, sLOX-1, sLOX1
UniProt P78380
Application Notes Immunohistochemistry on frozen sections. Immunoprecipitation. Flow Cytometry: 1:10, Use 10 μL of the suggested working dilution to label 10^6 cells in 100 μL. Western Blot: 1:10 - 1/100, This antibody detects intact 50 kDa LOX-1 and also a prominent 30 kDa proteolytic fragment in western blotting.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, 0.09 % Sodium Azide, 1 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1) (Extracellular Domain) antibody Anti-LOX-1 antibody ABIN121884 staining human umbilical vein endothelial cells
General Yoshida, Kondratenko, Green et al.: "Identification of the lectin-like receptor for oxidized low-density lipoprotein in human macrophages and its potential role as a scavenger receptor." in: The Biochemical journal, Vol. 334 ( Pt 1), pp. 9-13, 1998 (PubMed).

Morawietz, Rueckschloss, Niemann et al.: "Angiotensin II induces LOX-1, the human endothelial receptor for oxidized low-density lipoprotein." in: Circulation, Vol. 100, Issue 9, pp. 899-902, 1999 (PubMed).

Li, Liu, Chen et al.: "LOX-1, an oxidized LDL endothelial receptor, induces CD40/CD40L signaling in human coronary artery endothelial cells." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 23, Issue 5, pp. 816-21, 2003 (PubMed).

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