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TSC1 antibody (Tuberous Sclerosis 1)

Details for Product anti-TSC1 Antibody No. ABIN121908, Supplier: Login to see
Antigen
  • tsc1
  • wu:fc38b04
  • LAM
  • TSC
  • hamartin
  • mKIAA0243
Alternatives
anti-Human TSC1 antibody for Immunofluorescence
Reactivity
Human, Mouse (Murine), Rat (Rattus)
426
357
152
5
1
1
1
1
1
1
Host
Rabbit
728
37
19
1
Clonality
Polyclonal
Conjugate
This TSC1 antibody is un-conjugated
67
67
67
64
64
64
4
3
3
3
3
3
3
3
3
Application
Immunofluorescence (IF), Western Blotting (WB)
532
490
153
62
34
34
17
14
7
5
4
2
1
Supplier
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Specificity This antibody recognises an epitope within the internal region of the 130 kDa tumour suppressor protein, Tumour sclerosis complex 1 (TSC1).
Purification Affinity chromatography
Alternative Name TSC1 / Hamartin (TSC1 Antibody Abstract)
Background Mutation within the TSC1 gene is responsible for Tuberous sclerosis (TSC), an autosomal dominant genetic disorder associated with the development of benign tumors (hamartomas), a condition also induced by mutation of the Tumour sclerosis complex 2 (TSC2) gene. Many proteins have been shown to play a role in the regulation of the serine/threonine kinase known as target of rapamycin (TOR), a central component in a complex signaling pathway which controls cell proliferation and cell cycle progression. Negative regulation of TOR activity occurs following the over-expression of the TSC1 and TSC2 gene products, hamartin and tuberin. These act by suppressing the phosphorylation of eukaryotic translation initiation factor 4E binding protein 1 (4EBP1) and ribosomal protein S6 kinase (S6K), downstream targets of TOR involved in mRNA translation. Furthermore the TOR activator protein Rheb has been identified as a target of TSC1-TSC2 complexes.Synonyms: KIAA0243, TSC, Tuberous sclerosis 1 protein
Gene ID 7248
UniProt Q92574
Pathways RTK Signaling, AMPK Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline, 0.02 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Background publications Inoki, Ouyang, Li et al.: "Signaling by target of rapamycin proteins in cell growth control." in: Microbiology and molecular biology reviews : MMBR, Vol. 69, Issue 1, pp. 79-100, 2005 (PubMed).

Tee, Fingar, Manning et al.: "Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 21, pp. 13571-6, 2002 (PubMed).