Receptor Tyrosine Kinases (RTKs) are membrane bound kinases that are activated upon binding of receptor specific ligands. They make up the largest class of membrane receptors that trigger signaling cascades through their inherent enzymatic activity. These structures, activation mechanisms and key components of the signaling pathways are highly conserved in metazoans. There are 58 known RTKs in humans, which are grouped into 20 classes depending on topology.
RTKs are fairly promiscuous receptors, and activating stimuli comprise a plethora of growth factors, hormones, and cytokines. Most RTKs form dimers and become active upon ligand binding. The active RTK phosphorylates activators of downstream signaling cascades such as NF-kB, MAPK, Ca2+ dependent signaling, and the JAK-STAT pathway.
RTKs affect a wide spectrum of processes ranging from cytoskeleton dynamics, cell growth and differentiation to inflammation, apoptosis, and tumor progression. In spite of the exceptionally high variety of receptors and outcomes, RTKs engage only a limited set of core processes. Therefore, quantitative analysis of factors like an RTK’s expression profile are crucial for the understanding of the signaling processes and predicting qualitative outcomes.
ALK (Anaplastic Lymphoma Receptor tyrosine Kinase): | |||
ROS1 (C-Ros Oncogene 1 , Receptor tyrosine Kinase): | ROS1 antibodies | ROS1 ELISA Kits | ROS1 Proteins |
CSF1R (Colony Stimulating Factor 1 Receptor): | CSF1R antibodies | CSF1R ELISA Kits | CSF1R Proteins |
DDR1 (Discoidin Domain Receptor tyrosine Kinase 1): | DDR1 antibodies | DDR1 ELISA Kits | DDR1 Proteins |
DDR2 (Discoidin Domain Receptor tyrosine Kinase 2): | DDR2 antibodies | DDR2 ELISA Kits | DDR2 Proteins |
EPHA10 - EPH Receptor A10: | EPHA10 antibodies | EPHA10 ELISA Kits | EPHA10 Proteins |
EPHA2 - EPH Receptor A2: | EPHA2 antibodies | EPHA2 ELISA Kits | EPHA2 Proteins |
EPHA7 - EPH Receptor A7: | EPHA7 antibodies | EPHA7 ELISA Kits | EPHA7 Proteins |
EPHB1 - EPH Receptor B1: | EPHB1 antibodies | EPHB1 ELISA Kits | EPHB1 Proteins |
EPHB2 - EPH Receptor B2: | EPHB2 antibodies | EPHB2 ELISA Kits | EPHB2 Proteins |
EPHB3 - EPH Receptor B3: | EPHB3 antibodies | EPHB3 ELISA Kits | EPHB3 Proteins |
EPHB4 - EPH Receptor B4: | EPHB4 antibodies | EPHB4 ELISA Kits | EPHB4 Proteins |
EPHB6 - EPH Receptor B6: | EPHB6 antibodies | EPHB6 ELISA Kits | EPHB6 Proteins |
EGFR (Epidermal Growth Factor Receptor): | EGFR antibodies | EGFR ELISA Kits | EGFR Proteins |
FGFR3 (Fibroblast Growth Factor Receptor 3): | FGFR3 antibodies | FGFR3 ELISA Kits | FGFR3 Proteins |
FGFR4 (Fibroblast Growth Factor Receptor 4): | FGFR4 antibodies | FGFR4 ELISA Kits | FGFR4 Proteins |
FGFRL1 (Fibroblast Growth Factor Receptor-Like 1): | FGFRL1 antibodies | FGFRL1 ELISA Kits | FGFRL1 Proteins |
FLT1 (Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor)): | FLT1 antibodies | FLT1 ELISA Kits | FLT1 Proteins |
FLT3 (Fms-Related tyrosine Kinase 3): | FLT3 antibodies | FLT3 ELISA Kits | FLT3 Proteins |
FLT4 (Fms-Related Tyrosine Kinase 4): | FLT4 antibodies | FLT4 ELISA Kits | FLT4 Proteins |
INSRR (Insulin Receptor-Related Receptor): | INSRR antibodies | INSRR ELISA Kits | INSRR Proteins |
IGF1R (Insulin-Like Growth Factor 1 Receptor): | IGF1R antibodies | IGF1R ELISA Kits | IGF1R Proteins |
KDR - VEGFR2: | KDR antibodies | KDR ELISA Kits | KDR Proteins |
LMTK2 (Lemur tyrosine Kinase 2): | LMTK2 antibodies | LMTK2 ELISA Kits | LMTK2 Proteins |
LTK (Leukocyte Receptor tyrosine Kinase): | LTK antibodies | LTK ELISA Kits | LTK Proteins |
KIT (Mast/stem Cell Growth Factor Receptor): | KIT antibodies | KIT ELISA Kits | KIT Proteins |
MME (Membrane Metallo-Endopeptidase): | MME antibodies | MME ELISA Kits | MME Proteins |
MET (Met Proto-Oncogene): | MET antibodies | MET ELISA Kits | MET Proteins |
MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase): | MUSK antibodies | MUSK ELISA Kits | MUSK Proteins |
NTRK3 (Neurotrophic tyrosine Kinase, Receptor, Type 3): | NTRK3 antibodies | NTRK3 ELISA Kits | NTRK3 Proteins |
PDGFRA (Platelet-Derived Growth Factor Receptor, alpha Polypeptide): | PDGFRA antibodies | PDGFRA ELISA Kits | PDGFRA Proteins |
KCNH8 (Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 8): | KCNH8 antibodies | KCNH8 Proteins | |
PTK7 (PTK7 Protein tyrosine Kinase 7): | PTK7 antibodies | PTK7 ELISA Kits | PTK7 Proteins |
ROR1 (Receptor Tyrosine Kinase-Like Orphan Receptor 1): | ROR1 antibodies | ROR1 ELISA Kits | ROR1 Proteins |
ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2): | ROR2 antibodies | ROR2 ELISA Kits | ROR2 Proteins |
RET - Ret Proto-Oncogene: | RET antibodies | RET ELISA Kits | RET Proteins |
RYK (RYK Receptor-Like Tyrosine Kinase): | RYK antibodies | RYK ELISA Kits | RYK Proteins |
TEK (TEK Tyrosine Kinase, Endothelial): | TEK antibodies | TEK ELISA Kits | TEK Proteins |
TIE1 (tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1): | TIE1 antibodies | TIE1 ELISA Kits | TIE1 Proteins |
ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian)): | ERBB4 antibodies | ERBB4 ELISA Kits | ERBB4 Proteins |
ERBB2 - HER2: | ERBB2 antibodies | ERBB2 ELISA Kits | ERBB2 Proteins |
ERBB3 (V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian)): | ERBB3 antibodies | ERBB3 ELISA Kits | ERBB3 Proteins |
GAB1 (GRB2-Associated Binding Protein 1): | |||
GRB2 (Growth Factor Receptor-Bound Protein 2): | GRB2 antibodies | GRB2 ELISA Kits | GRB2 Proteins |
SHC3 (SHC (Src Homology 2 Domain Containing) Transforming Protein 3): | SHC3 antibodies | SHC3 Proteins |
RAPGEF5 - GFR: | RAPGEF5 antibodies | RAPGEF5 Proteins | |
SOS2 (Son of Sevenless Homolog 2 (Drosophila)): | SOS2 antibodies | SOS2 Proteins |
CDC42 (Cell Division Cycle 42 (GTP Binding Protein, 25kDa)): | CDC42 antibodies | CDC42 ELISA Kits | CDC42 Proteins |
NRAS - GTPase NRas: | NRAS antibodies | NRAS ELISA Kits | NRAS Proteins |
HRAS (V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog): | HRAS antibodies | HRAS ELISA Kits | HRAS Proteins |
RAC3 (Ras-Related C3 Botulinum Toxin Substrate 3 (Rho Family, Small GTP Binding Protein Rac3)): | RAC3 antibodies | RAC3 Proteins |
FRAP1 - MTOR: | FRAP1 antibodies | FRAP1 ELISA Kits | FRAP1 Proteins |
MAP2K1 (Mitogen-Activated Protein Kinase Kinase 1): | MAP2K1 antibodies | MAP2K1 ELISA Kits | MAP2K1 Proteins |
MAP2K2 (Mitogen-Activated Protein Kinase Kinase 2): | MAP2K2 antibodies | MAP2K2 ELISA Kits | MAP2K2 Proteins |
PIK3CA (Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide): | PIK3CA antibodies | PIK3CA ELISA Kits | PIK3CA Proteins |
PIK3CG (Phosphoinositide-3-Kinase, Catalytic, gamma Polypeptide): | PIK3CG antibodies | PIK3CG Proteins | |
PRKCZ - PKC zeta: | PRKCZ antibodies | PRKCZ ELISA Kits | PRKCZ Proteins |
PDK1 (Pyruvate Dehydrogenase Kinase, Isozyme 1): | PDK1 antibodies | PDK1 ELISA Kits | PDK1 Proteins |
PDK2 (Pyruvate Dehydrogenase Kinase, Isozyme 2): | PDK2 antibodies | PDK2 ELISA Kits | PDK2 Proteins |
RPS6KB1 (Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1): | RPS6KB1 antibodies | RPS6KB1 ELISA Kits | RPS6KB1 Proteins |
RPS6KB2 (Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2): | RPS6KB2 antibodies | RPS6KB2 ELISA Kits | RPS6KB2 Proteins |
Calm2 - Calmodulin 2: | Calm2 antibodies | Calm2 Proteins | |
CALM3 - Calmodulin 3: | CALM3 antibodies | CALM3 ELISA Kits |
PPP3CB (Protein Phosphatase 3, Catalytic Subunit, beta Isozyme): | PPP3CB antibodies | PPP3CB Proteins | |
PPP3CC (Protein Phosphatase 3, Catalytic Subunit, gamma Isozyme): | PPP3CC antibodies | PPP3CC Proteins | |
PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, alpha): | PPP3R1 antibodies | PPP3R1 ELISA Kits | PPP3R1 Proteins |
CHUK (conserved Helix-Loop-Helix Ubiquitous Kinase): | CHUK antibodies | CHUK ELISA Kits | CHUK Proteins |
IKBKG (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma): | IKBKG antibodies | IKBKG ELISA Kits | IKBKG Proteins |
JAK3 (Tyrosine-Protein Kinase JAK3): | JAK3 antibodies | JAK3 ELISA Kits | JAK3 Proteins |
ARAF (V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog): | ARAF antibodies | ARAF ELISA Kits | ARAF Proteins |
BRAF (V-Raf Murine Sarcoma Viral Oncogene Homolog B1): | BRAF antibodies | BRAF ELISA Kits | BRAF Proteins |
RAF1 (V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1): | RAF1 antibodies | RAF1 ELISA Kits | RAF1 Proteins |
NFAT5 (Nuclear Factor of Activated T-Cells 5, Tonicity-Responsive): | NFAT5 antibodies | NFAT5 ELISA Kits | NFAT5 Proteins |
NFAT1 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2): | NFAT1 antibodies | NFAT1 ELISA Kits | NFAT1 Proteins |
NFATC3 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 3): | NFATC3 antibodies | NFATC3 ELISA Kits | NFATC3 Proteins |
NFATC4 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 4): | NFATC4 antibodies | NFATC4 ELISA Kits | NFATC4 Proteins |
NFKB1 (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 1): | NFKB1 antibodies | NFKB1 ELISA Kits | NFKB1 Proteins |
STAT5A (Signal Transducer and Activator of Transcription 5A): | STAT5A antibodies | STAT5A ELISA Kits | STAT5A Proteins |
STAT5B (Signal Transducer and Activator of Transcription 5B): | STAT5B antibodies | STAT5B ELISA Kits | STAT5B Proteins |
RELB - V-Rel Reticuloendotheliosis Viral Oncogene Homolog B: | RELB antibodies | RELB ELISA Kits | RELB Proteins |
CYFIP2 (Cytoplasmic FMR1 Interacting Protein 2): | CYFIP2 antibodies | CYFIP2 ELISA Kits | CYFIP2 Proteins |
ARPC2 (Actin Related Protein 2/3 Complex, Subunit 2, 34kDa): | ARPC2 antibodies | ARPC2 ELISA Kits | ARPC2 Proteins |
ARPC3 (Actin Related Protein 2/3 Complex, Subunit 3, 21kDa): | ARPC3 antibodies | ARPC3 ELISA Kits | ARPC3 Proteins |
ARPC4 (Actin Related Protein 2/3 Complex, Subunit 4, 20kDa): | ARPC4 antibodies | ARPC4 ELISA Kits | ARPC4 Proteins |
ARPC5 (Actin Related Protein 2/3 Complex, Subunit 5, 16kDa): | ARPC5 antibodies | ARPC5 ELISA Kits | ARPC5 Proteins |
ACTR3 (ARP3 Actin-Related Protein 3 Homolog (Yeast)): | ACTR3 antibodies | ACTR3 ELISA Kits | ACTR3 Proteins |
BRK1 (BRICK1, SCAR/WAVE Actin-Nucleating Complex Subunit): | BRK1 antibodies | BRK1 ELISA Kits | BRK1 Proteins |
RPTOR - Raptor: | RPTOR antibodies | RPTOR ELISA Kits | RPTOR Proteins |
WASF1 (WAS Protein Family, Member 1): | WASF1 antibodies | WASF1 ELISA Kits | WASF1 Proteins |
WASF2 (WAS Protein Family, Member 2): | WASF2 antibodies | WASF2 ELISA Kits | WASF2 Proteins |
WASF3 (WAS Protein Family, Member 3): | WASF3 antibodies | WASF3 Proteins | |
WIPF1 (WAS/WASL Interacting Protein Family, Member 1): | WIPF1 antibodies | WIPF1 Proteins |