Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) antibody

Details for Product No. ABIN121915
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Synonyms AW556805, Mcl-1, BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, TM, bcl2-L-3, mcl1/EAT, mcl-1
(290), (86), (61), (8), (4), (4), (4), (3), (2), (1), (1), (1)
(200), (74), (17), (2)
(10), (7), (7), (5), (5), (5), (2), (2), (2), (2), (2), (2), (2), (2)
Immunofluorescence (IF), Western Blotting (WB)
(250), (114), (96), (74), (56), (39), (27), (25), (20), (11), (10), (6), (6), (5), (1), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
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Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN121915
456.50 $
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Specificity This antibody recognizes an epitope within the central region (IN) of Myeloid cell leukaemia sequence 1 (MCL-1). SP2170P recognises both the MCL-1L (38 kDa) and MCL-1S (30 kDa) isoforms of MCL-1.
Purification Ion Exchange Chromatography.
Alternative Name MCL1
Background MCL-1 is an anti-apoptotic member of the Bcl-2 family of proteins, first identified in differentiating ML-1 myeloid cells, and expressed in many different cell lines, tissues and a variety of tumours. The MCL-1 protein, localised to intracellular membranes and particularly mitochondrial membranes, has since been isolated in two distinct isoforms, known as MCL-1 long (MCL-1L) and MCL-1 short (MCL-1S). MCL-1S has been identified as a pro-apoptotic splice variant of MCL-1L, missing the transmembrane and BH1 and BH2 (Bcl-2 homology) domains. Interaction between these two antagonistic variants can act to regulate cell survival.Synonyms: BCL2L3, Bcl-2-like protein 3, Bcl-2-related protein, EAT, Induced myeloid leukemia cell differentiation protein Mcl-1, mcl1/EAT, r004
Gene ID 4170
UniProt Q07820
Research Area Cancer, Apoptosis/Necrosis
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
General Bae, Leo, Hsu et al.: "MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain." in: The Journal of biological chemistry, Vol. 275, Issue 33, pp. 25255-61, 2000 (PubMed).

Rinkenberger, Horning, Klocke et al.: "Mcl-1 deficiency results in peri-implantation embryonic lethality." in: Genes & development, Vol. 14, Issue 1, pp. 23-7, 2000 (PubMed).

Kozopas, Yang, Buchan et al.: "MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 8, pp. 3516-20, 1993 (PubMed).

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