Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) antibody

Details for Product No. ABIN121915
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Antigen
Synonyms AW556805, Mcl-1, BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, TM, bcl2-L-3, mcl1/EAT, mcl-1
Reactivity
Human
(229), (82), (59), (18), (12), (3), (3), (2), (2), (1)
Host
Rabbit
(162), (64), (5), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(7), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Immunofluorescence (IF), Western Blotting (WB)
(192), (84), (74), (66), (52), (43), (22), (20), (19), (11), (11), (6), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN121915
456.50 $
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Specificity This antibody recognizes an epitope within the central region (IN) of Myeloid cell leukaemia sequence 1 (MCL-1). SP2170P recognises both the MCL-1L (38 kDa) and MCL-1S (30 kDa) isoforms of MCL-1.
Purification Ion Exchange Chromatography.
Alternative Name MCL1
Background MCL-1 is an anti-apoptotic member of the Bcl-2 family of proteins, first identified in differentiating ML-1 myeloid cells, and expressed in many different cell lines, tissues and a variety of tumours. The MCL-1 protein, localised to intracellular membranes and particularly mitochondrial membranes, has since been isolated in two distinct isoforms, known as MCL-1 long (MCL-1L) and MCL-1 short (MCL-1S). MCL-1S has been identified as a pro-apoptotic splice variant of MCL-1L, missing the transmembrane and BH1 and BH2 (Bcl-2 homology) domains. Interaction between these two antagonistic variants can act to regulate cell survival.Synonyms: BCL2L3, Bcl-2-like protein 3, Bcl-2-related protein, EAT, Induced myeloid leukemia cell differentiation protein Mcl-1, mcl1/EAT, r004
Gene ID 4170
UniProt Q07820
Research Area Cancer, Apoptosis/Necrosis
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
General Kozopas, Yang, Buchan et al.: "MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 8, pp. 3516-20, 1993 (PubMed).

Rinkenberger, Horning, Klocke et al.: "Mcl-1 deficiency results in peri-implantation embryonic lethality." in: Genes & development, Vol. 14, Issue 1, pp. 23-7, 2000 (PubMed).

Bae, Leo, Hsu et al.: "MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain." in: The Journal of biological chemistry, Vol. 275, Issue 33, pp. 25255-61, 2000 (PubMed).

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