Ring Finger Protein 216 (RNF216) (N-Term) antibody

Details for Product No. ABIN121917
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Antigen
Synonyms RGD1565135, TRIAD3, RNF216, zin, u7i1, triad3, ubce7ip1, MGC147026, 2810055g22rik, 2810055G22Rik, AI647468, AU019462, C86502, F830018F18Rik, UIP83, Ubce7ip1, CAHH, U7I1, UBCE7IP1, ZIN
Epitope
N-Term
(12), (8), (3), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine)
(38), (31), (12), (12)
Host
Rabbit
(48), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(37), (16), (15), (14), (10), (5), (4), (2), (1)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN121917
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Purification Ion exchange chromatography
Alternative Name RNF216
Background TRIAD3A is a ubiquitously expressed E3 ubiquitin-protein ligase which plays an important role in the innate immune response. Regulation of the level and duration of Toll-like receptor (TLR) activation is vital in controlling a pro-inflammatory response, to prevent harm to the host. Several proteins involved in the regulation of TLR signaling have been described including ST2 and IL-1R-associated kinase M, along with many other adaptor proteins of the MyD88 family, which mediate TLR signal transduction. TRIAD3A, identified as a RING finger member of the E3 ligase family of proteins, binds to the cytoplasmic tail of several TLRs, notably TLR4 and TLR9, resulting in ubiquitination and proteolytic degradation, thereby regulating their expression. TRIAD3A does not appear to regulate the expression of TLR2.Synonyms: E3 ubiquitin-protein ligase RNF216, RING finger protein 216, TRIAD3, Triad domain-containing protein 3, UBCE7IP1, Ubiquitin-conjugating enzyme 7-interacting protein 1, ZIN, Zinc finger protein inhibiting NF-kappa-B
UniProt Q9NWF9
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline, 0.02 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
General Brint, Xu, Liu et al.: "ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance." in: Nature immunology, Vol. 5, Issue 4, pp. 373-9, 2004 (PubMed).

Chuang, Ulevitch: "Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors." in: Nature immunology, Vol. 5, Issue 5, pp. 495-502, 2004 (PubMed).

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