RNF216 antibody

Catalog No. ABIN1386955

This Rabbit Polyclonal antibody specifically detects RNF216 in IF, IHC (p) and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for RNF216 antibody (ABIN1386955)

Target: RNF216 (Ring Finger Protein 216 (RNF216))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF216 antibody is un-conjugated

Application: Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-RNF216 Antibody

Purpose: RNF216 Polyclonal Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TRIAD3

Isotype: IgG

Application Details

Application Notes: IHC-P(1:200-400), IHC-F(1:100-500), IF()

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for RNF216

Target: RNF216 (Ring Finger Protein 216 (RNF216))

Alternative Name: TRIAD3

Background:

Synonyms: E3 ubiquitin ligase TRIAD3, ring finger protein 216, RNF216, Triad domain-containing protein 3, U7I1, UBCE7IP1, Ubiquitin conjugating enzyme 7 interacting protein 1, UiP83, ZIN, Zinc finger protein inhibiting NF kappa B, RN216_HUMAN.

Background: The TRIAD3 gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known.

Gene ID: 54476