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Synaptophysin antibody (SYP)

Details for Product anti-SYP Antibody No. ABIN126707, Supplier: Login to see
Antigen
  • syp-B
  • xsypii
  • MGC86267
  • MRXSYP
  • A230093K24Rik
  • AI848995
  • Syn
  • p38
  • Syp1
  • mrxsyp
  • syp
  • xsypi
Reactivity
Cow (Bovine), Human, Mouse (Murine), Rat (Rattus)
251
87
69
28
8
6
4
3
3
3
1
1
1
1
Host
Mouse
188
121
6
1
Clonality (Clone)
Monoclonal ()
Conjugate
This Synaptophysin antibody is un-conjugated
8
5
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
234
123
84
58
43
31
18
17
12
4
4
4
4
3
1
1
Supplier
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Immunogen Synaptophysin from presynaptic vesicles, prepared from bovine brain.
Clone SY38
Isotype IgG1
Specificity SY38 represents an excellent Marker for several neuroendocrine, neuronal and adrenal tumors. Neuronal and adrenal tumors such as pheochromocytomas, paragangliomas, neuroblastomas, ganglioneuroblastomas. Neuroendocrine tumors of epithelial origin: Pancreatic islet cell carcinoma, bronchial and gastrointestinal carcinoids, medullary carcinoma of thyroid. Polypeptide Reacting: Mr 38 000 transmembrane glycoprotein of presynaptic vesicles. Reactivity on Cultured Cell Lines: Rat PC-12 cell line.
Purification Affinity Chromatography on Protein A.
Alternative Name Synaptophysin / SYP (SYP Antibody Abstract)
Background Synaptophysin is a glycoprotein present in the membrane of neuronal presynaptic vesicles in brain, spinal cord, retina, vesicles of adrenal medulla, neuromuscular junctions, and endocrine cells. It is also expressed by neuroendocrine cells throughout the body, both normal and neoplastic. Synaptophysin is a useful marker for the identification of normal neuroendocrine cells and neuroendocrine neoplasms. This antibody reacts with neuroendocrine cells of human adrenal medulla, carotid body, skin, pituitary gland, thyroid, lung, pancreas, and gastointestinal mucosa. It also reacts with a wide spectrum of neuroendocrine neoplasms of neural type including neuroblastomas, ganglioneuroblastomas, ganglioneuromas, pheochromocytomas, chromaffin, and non chromaffin paragangliomas.Synonyms: Major synaptic vesicle protein p38, Neuroendocrine Marker
Gene ID 6855
NCBI Accession NP_003170
UniProt P08247
Pathways
Application Notes Immunoblotting. Immunofluorescence. Cytological Material. Immunohistochemistry on Frozen and Paraffin Sections: 1/50 with PBS, pH 7.4. In no case Protease Pretreatment. Incubation Time: 1 h at RT, extended with Paraffin.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore in 1 mL distilled water.
Buffer Final Solution contains PBS, pH 7.4 with 0.09 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8 °C. Following reconstitution store the antibody (in aliquots) at -20 °C.
Background publications Kelly, Delclos, Morice et al.: "High-dose-rate endobronchial brachytherapy effectively palliates symptoms due to airway tumors: the 10-year M. D. Anderson cancer center experience." in: International journal of radiation oncology, biology, physics, Vol. 48, Issue 3, pp. 697-702, 2000 (PubMed).

Kelly, Buckley, Burgess et al.: "Membrane traffic in neurons and peptide-secreting cells." in: Cold Spring Harbor symposia on quantitative biology, Vol. 48 Pt 2, pp. 697-705, 1984 (PubMed).

Wiedenmann, Franke: "Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles." in: Cell, Vol. 41, Issue 3, pp. 1017-28, 1985 (PubMed).

Gould: "Synaptophysin. A new and promising pan-neuroendocrine marker." in: Archives of pathology & laboratory medicine, Vol. 111, Issue 9, pp. 791-4, 1987 (PubMed).

Gould, Wiedenmann, Lee et al.: "Synaptophysin expression in neuroendocrine neoplasms as determined by immunocytochemistry." in: The American journal of pathology, Vol. 126, Issue 2, pp. 243-57, 1987 (PubMed).

Gould, Lee, Wiedenmann et al.: "Synaptophysin: a novel marker for neurons, certain neuroendocrine cells, and their neoplasms." in: Human pathology, Vol. 17, Issue 10, pp. 979-83, 1986 (PubMed).

Wiedenmann, Franke, Kuhn et al.: "Synaptophysin: a marker protein for neuroendocrine cells and neoplasms." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, Issue 10, pp. 3500-4, 1986 (PubMed).