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Details for Product No. ABIN1449192

Milk Fat Globule-EGF Factor 8 Protein (MFGE8) antibody

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BA46, EDIL1, HMFG, HsT19888, MFG-E8, MFGM, OAcGD3S, SED1, SPAG10, hP47, AA408458, AI325141, Mfgm, P47, lactadherin, AGS, MFGME8, MFGMP-E8, ba46, edil1, oacgd3s, MGC75581, hst19888, MGC145109, MFGE8, m ... show more
»Alternatives Mouse (Murine)
»Alternatives Hamster
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives Flow Cytometry (FACS), Immunoprecipitation (IP)
Pubmed 4 references available
Catalog no. ABIN1449192
Quantity 0.1 mg
324.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Thioglycollate-elicited mouse peritoneal macrophages
Clone YT1-24
Isotype IgG
Specificity This antibody reacts with MFG-E8 short and long form.
Purification Protein A agarose
Alternative Name Lactadherin
Background Apoptotic cells are rapidly removed by phagocytosis to clear the living cells and tissues of intracellular materials being released from dying cells. Phagocytes recognize apoptotic cells through milk fat globule-EGF-factor 8 (MFG-E8). MFG-E8 is a secreted glycoprotein from thioglycollate-elicited macrophages and bind to phosphatidylserine exposed on the cell surface of apoptotic cells, then bind strongly to cells expressing alphanybeta3 integrin via its RGD (arginine-glycine-aspartate) motif. Thus, MFG-E8 is an important protein to mediate the engulfment of apoptotic cells by activated macrophages.
Alternate names: Breast epithelial antigen BA46, HMFG, MFGE8, MFGM, Milk fat globule-EGF factor 8
Gene ID 4240
NCBI Accession NP_001108086.1
UniProt Q08431
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 50% glycerol, pH 7.2. No preservative is contained.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Upon receipt, store (in aliqouts) at -20 °C.
Expiry Date 12 months
Background publications Hanayama, Tanaka, Miyasaka et al.: "Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice." in: Science (New York, N.Y.), Vol. 304, Issue 5674, pp. 1147-50, 2004 (PubMed).

Morelli, Larregina, Shufesky et al.: "Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells." in: Blood, Vol. 104, Issue 10, pp. 3257-66, 2004 (PubMed).

Fens, Mastrobattista, de Graaff et al.: "Angiogenic endothelium shows lactadherin-dependent phagocytosis of aged erythrocytes and apoptotic cells." in: Blood, Vol. 111, Issue 9, pp. 4542-50, 2008 (PubMed).

Montecalvo, Shufesky, Stolz et al.: "Exosomes as a short-range mechanism to spread alloantigen between dendritic cells during T cell allorecognition." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 5, pp. 3081-90, 2008 (PubMed).

Alternatives for antigen "Milk Fat Globule-EGF Factor 8 Protein (MFGE8)", type "Antibodies"
Hosts (28), (23), (2), (1)
Reactivities (50), (3)
Applications (43), (25), (18), (17), (11), (10), (5), (5), (4), (3), (3), (1), (1), (1)
Conjugates (5), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (3), (3), (2), (2)