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MFGE8 antibody

MFGE8 Reactivity: Mouse FACS, IP Host: Hamster Monoclonal 2422 unconjugated
Catalog No. ABIN1449192
  • Target See all MFGE8 Antibodies
    MFGE8 (Milk Fat Globule-EGF Factor 8 Protein (MFGE8))
    Reactivity
    • 67
    • 9
    • 4
    • 3
    Mouse
    Host
    • 49
    • 22
    • 3
    • 1
    Hamster
    Clonality
    • 53
    • 22
    Monoclonal
    Conjugate
    • 44
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MFGE8 antibody is un-conjugated
    Application
    • 59
    • 22
    • 22
    • 18
    • 13
    • 13
    • 12
    • 12
    • 10
    • 7
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    Flow Cytometry (FACS), Immunoprecipitation (IP)
    Specificity
    This antibody reacts with MFG-E8 short and long form.
    Cross-Reactivity (Details)
    Species reactivity (tested):Mouse
    Purification
    Protein A agarose
    Immunogen
    Thioglycollate-elicited mouse peritoneal macrophages
    Clone
    2422
    Isotype
    IgG
    Top Product
    Discover our top product MFGE8 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
    Preservative
    Without preservative
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Upon receipt, store (in aliqouts) at -20 °C.
  • Target
    MFGE8 (Milk Fat Globule-EGF Factor 8 Protein (MFGE8))
    Alternative Name
    Lactadherin (MFGE8 Products)
    Background
    Apoptotic cells are rapidly removed by phagocytosis to clear the living cells and tissues of intracellular materials being released from dying cells. Phagocytes recognize apoptotic cells through milk fat globule-EGF-factor 8 (MFG-E8). MFG-E8 is a secreted glycoprotein from thioglycollate-elicited macrophages and bind to phosphatidylserine exposed on the cell surface of apoptotic cells, then bind strongly to cells expressing ανβ3 integrin via its RGD (arginine-glycine-aspartate) motif. Thus, MFG-E8 is an important protein to mediate the engulfment of apoptotic cells by activated macrophages.Synonyms: Breast epithelial antigen BA46, HMFG, MFGE8, MFGM, Milk fat globule-EGF factor 8
    Gene ID
    4240
    NCBI Accession
    NP_001108086
    UniProt
    Q08431
    Pathways
    SARS-CoV-2 Protein Interactome
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