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Details for Product No. ABIN1449223

Milk Fat Globule-EGF Factor 8 Protein (MFGE8) antibody

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BA46, EDIL1, HMFG, HsT19888, MFG-E8, MFGM, OAcGD3S, SED1, SPAG10, hP47, AA408458, AI325141, Mfgm, P47, lactadherin, AGS, MFGME8, MFGMP-E8, ba46, edil1, oacgd3s, MGC75581, hst19888, MGC145109, MFGE8, m ... show more
»Alternatives Mouse (Murine)
»Alternatives Hamster
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN1449223
Quantity 0.1 mg
324.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Recombinant mouse MFG-E8
Clone 18A2-G10
Isotype IgG
Specificity This antibody reacts withMFG-E8 short and long forms.
Purification Protein A agarose
Alternative Name Lactadherin
Background Apoptotic cells are rapidly removed by phagocytosis to clear the living cells and tissues of intracellular materials being released from dying cells. Phagocytes recognize apoptotic cells through milk fat globule-EGF-factor 8 (MFG-E8). MFG-E8 is a secreted glycoprotein from thioglycollate-elicited macrophages and bind to phosphatidylserine exposed on the cell surface of apoptotic cells, then bind strongly to cells expressing avß3 integrin via its RGD (arginine-glycine-aspartate) motif. Thus, MFG-E8 is an important protein to mediate the engulfment of apoptotic cells by activated macrophages.
Alternate names: Breast epithelial antigen BA46, HMFG, MFGE8, MFGM, Milk fat globule-EGF factor 8
Gene ID 4240
NCBI Accession NP_001108086.1
UniProt Q08431
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 50% glycerol, pH 7.2. No preservative is contained.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Upon receipt, store (in aliquots) at -20 °C.
Expiry Date 12 months
Background publications Hanayama, Tanaka, Miwa et al.: "Expression of developmental endothelial locus-1 in a subset of macrophages for engulfment of apoptotic cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 6, pp. 3876-82, 2004 (PubMed).

Miyasaka, Hanayama, Tanaka et al.: "Expression of milk fat globule epidermal growth factor 8 in immature dendritic cells for engulfment of apoptotic cells." in: European journal of immunology, Vol. 34, Issue 5, pp. 1414-22, 2004 (PubMed).

Hanayama, Tanaka, Miyasaka et al.: "Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice." in: Science (New York, N.Y.), Vol. 304, Issue 5674, pp. 1147-50, 2004 (PubMed).

Hanayama, Nagata: "Impaired involution of mammary glands in the absence of milk fat globule EGF factor 8." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 46, pp. 16886-91, 2005 (PubMed).

Kranich, Krautler, Heinen et al.: "Follicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge8." in: The Journal of experimental medicine, Vol. 205, Issue 6, pp. 1293-302, 2008 (PubMed).

Alternatives for antigen "Milk Fat Globule-EGF Factor 8 Protein (MFGE8)", type "Antibodies"
Hosts (28), (23), (2), (1)
Reactivities (50), (3)
Applications (42), (25), (18), (18), (11), (10), (6), (5), (3), (3), (3), (1), (1), (1)
Conjugates (5), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (3), (3), (2), (2)