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Details for Product No. ABIN1449223

Milk Fat Globule-EGF Factor 8 Protein (MFGE8) antibody

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Antigen
Synonyms
BA46, EDIL1, HMFG, HsT19888, MFG-E8, MFGM, OAcGD3S, SED1, SPAG10, hP47, AA408458, AI325141, Mfgm, P47, lactadherin, AGS, MFGME8, MFGMP-E8, ba46, edil1, oacgd3s, MGC75581, hst19888, MGC145109, MFGE8, m ... show more
Reactivity
»Alternatives Mouse (Murine)
Host
»Alternatives Hamster
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN1449223
Quantity 0.1 mg
Price
324.50 $   Plus shipping costs $45.00
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anti-Milk Fat Globule-EGF Factor 8 Protein (MFGE8) antibody

Product details

Target Details Application Details Handling Images References Alternatives back to top
Immunogen Recombinant mouse MFG-E8
Clone 18A2-G10
Isotype IgG
Specificity This antibody reacts withMFG-E8 short and long forms.
Purification Protein A agarose

Target Details

Application Details Handling Images References Alternatives back to top
Alternative Name Lactadherin
Background Apoptotic cells are rapidly removed by phagocytosis to clear the living cells and tissues of intracellular materials being released from dying cells. Phagocytes recognize apoptotic cells through milk fat globule-EGF-factor 8 (MFG-E8). MFG-E8 is a secreted glycoprotein from thioglycollate-elicited macrophages and bind to phosphatidylserine exposed on the cell surface of apoptotic cells, then bind strongly to cells expressing avß3 integrin via its RGD (arginine-glycine-aspartate) motif. Thus, MFG-E8 is an important protein to mediate the engulfment of apoptotic cells by activated macrophages.
Alternate names: Breast epithelial antigen BA46, HMFG, MFGE8, MFGM, Milk fat globule-EGF factor 8
Gene ID 4240
NCBI Accession NP_001108086.1
UniProt Q08431

Application Details

Target Details Handling Images References Alternatives back to top
Restrictions For Research Use only

Handling

Target Details Application Details Images References Alternatives back to top
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 50% glycerol, pH 7.2. No preservative is contained.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Upon receipt, store (in aliquots) at -20 °C.
Expiry Date 12 months

References

Target Details Application Details Handling Images Alternatives back to top
Background publications Hanayama, Tanaka, Miwa et al.: "Expression of developmental endothelial locus-1 in a subset of macrophages for engulfment of apoptotic cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 6, pp. 3876-82, 2004 (PubMed).

Miyasaka, Hanayama, Tanaka et al.: "Expression of milk fat globule epidermal growth factor 8 in immature dendritic cells for engulfment of apoptotic cells." in: European journal of immunology, Vol. 34, Issue 5, pp. 1414-22, 2004 (PubMed).

Hanayama, Tanaka, Miyasaka et al.: "Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice." in: Science (New York, N.Y.), Vol. 304, Issue 5674, pp. 1147-50, 2004 (PubMed).

Hanayama, Nagata: "Impaired involution of mammary glands in the absence of milk fat globule EGF factor 8." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 46, pp. 16886-91, 2005 (PubMed).

Kranich, Krautler, Heinen et al.: "Follicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge8." in: The Journal of experimental medicine, Vol. 205, Issue 6, pp. 1293-302, 2008 (PubMed).

Alternatives

Target Details Application Details Handling Images References back to top
Alternatives for antigen "Milk Fat Globule-EGF Factor 8 Protein (MFGE8)", type "Antibodies"
Hosts (28), (23), (2), (1)
Reactivities (50), (3)
Applications (42), (25), (18), (18), (11), (10), (6), (5), (3), (3), (3), (1), (1), (1)
Conjugates (5), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (3), (3), (2), (2)
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