DBN1 antibody (N-Term)
-
- Target See all DBN1 Antibodies
- DBN1 (Drebrin 1 (DBN1))
-
Binding Specificity
- AA 1-326, N-Term
-
Reactivity
- Human
-
Host
- Mouse
-
Clonality
- Monoclonal
-
Conjugate
- This DBN1 antibody is un-conjugated
-
Application
- Western Blotting (WB), Flow Cytometry (FACS)
- Cross-Reactivity (Details)
- Species reactivity (tested):Human.
- Purification
- Affinity Chromatography on Protein A
- Immunogen
- Bacterially expressed N-terminal fragment of recombinant human drebrin (aa 1-326)
- Clone
- DBN-N-03
- Isotype
- IgG2b
- Top Product
- Discover our top product DBN1 Primary Antibody
-
-
- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
-
- Concentration
- 1.0 mg/mL
- Buffer
- Tris buffered saline (TBS), pH ~8.0, 15 mM Sodium Azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
-
- Target
- DBN1 (Drebrin 1 (DBN1))
- Alternative Name
- Drebrin (DBN1 Products)
- Background
- Drebrin is an actin-binding protein, which is expressed mainly in neurons and plays important role in their morphogenesis. The highest level of its expression is in developing brain. Both in neurons and non-neuronal cells drebrin acts as a key regulator of actin cytoskeleton remodelling, affecting especially intercellular junctions, such as dendritic spines of neurons or the immune synapses of T cells. Decrease of drebrin amount in the brain seems to be associated with Alzheimer's disease and Down syndrome, and in case of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) lower drebrin expression correlates with higher risk of relapse.Synonyms: D0S117E, DBN-1, DBN1, DKFZp434D064, Developmentally-regulated brain protein, drebrin 1
- Gene ID
- 1627
- NCBI Accession
- NP_004386
- UniProt
- Q16643
- Pathways
- Maintenance of Protein Location
-