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TFG antibody

Details for Product No. ABIN1449384, Supplier: Login to see
Antigen
  • wu:fb11c10
  • zgc:55342
  • zgc:77230
  • HMSNP
  • SPG57
  • TF6
  • TRKT3
  • AI173908
Reactivity
Human
68
11
10
3
3
3
3
3
2
2
1
Host
Mouse
58
10
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
4
4
4
4
4
4
Application
Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
63
32
11
8
7
4
1
1
Supplier
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Immunogen Human recombinant protein Trx-his-NTFG.
Clone TFG-03
Isotype IgG2b
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity Chromatography on Protein A
Background TFG (TRK-fused gene protein) is a regulatory protein with not fully understood function. Its defects are associated with various carcinomas, such as e.g. melanoma, thyroid papillary carcinoma, or glioma. TFG structure (multiple protein interaction motifs) indicated it can be an adaptor protein. It has been demonstrated TFG interacts with proteins modulating the NFkappaB pathway (TANK and NEMO). TNG enhances the effect of TNFalpha, TANK, TRAF2 and TRAF6 in inducing NFkappaB activity.Synonyms: TRK-fused gene protein
Gene ID 10342
NCBI Accession NP_001007566
UniProt Q92734
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Azide Free PBS, pH ~7.4 preserved by filter sterilization
Preservative Azide free
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Matsuda, Suzuki, Honda et al.: "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways." in: Oncogene, Vol. 22, Issue 21, pp. 3307-18, 2003 (PubMed).