C-Type Lectin Domain Family 7, Member A (CLEC7A) (Middle Region) antibody

Details for Product No. ABIN1449932
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Antigen
Synonyms CLEC7A, BGR, Clecsf12, beta-GR, CANDF4, CLECSF12, DECTIN1, Clec7b, RGD1565140
Epitope
Middle Region
(12), (7), (7), (7), (4), (2), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(51), (48), (19)
Host
Rabbit
(40), (23), (17)
Clonality
Polyclonal
Conjugate
Un-conjugated
(13), (9), (5), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(39), (26), (17), (10), (8), (8), (7), (6), (4), (2)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN1449932
401.50 $
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  • +1 404 474 4654
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Immunogen 17 amino acid synthetic peptide near the center of Human CLEC7A
Isotype IgG
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse, Rat.
Purification Affinity chromatography purified via peptide column
Alternative Name CLEC7A / Dectin-1
Background CLEC7A, also known as dectin-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily and is predominantly expressed on myeloid cells. It is a small glycoprotein type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM). CLEC7A functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, triggering a massive oxidative burst through the formation of reactive oxygen species.Synonyms: BGR, Beta-glucan receptor, C-type lectin domain family 7 member A, C-type lectin superfamily member 12, CLECSF12, DC-associated C-type lectin 1, DECTIN1, Dendritic cell-associated C-type lectin 1
Gene ID 64581
NCBI Accession NP_922938
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Taylor, Brown, Reid et al.: "The beta-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 7, pp. 3876-82, 2002 (PubMed).

Ebner, Sharon, Ben-Tal: "Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily." in: Proteins, Vol. 53, Issue 1, pp. 44-55, 2003 (PubMed).

Underhill, Rossnagle, Lowell et al.: "Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production." in: Blood, Vol. 106, Issue 7, pp. 2543-50, 2005 (PubMed).

Kerrigan, Brown: "Syk-coupled C-type lectin receptors that mediate cellular activation via single tyrosine based activation motifs." in: Immunological reviews, Vol. 234, Issue 1, pp. 335-52, 2010 (PubMed).

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