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Details for Product No. ABIN1449932

C-Type Lectin Domain Family 7, Member A (CLEC7A) (Middle Region) antibody

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Antigen
Synonyms BGR, beta-GR, Clecsf12, CANDF4, CLECSF12, DECTIN1, Clec7b, RGD1565140, CLEC7A
Epitope
»Alternatives Middle Region
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (IF), ELISA, Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN1449932
Quantity 0.1 mg
Price
390.50 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 6 to 8 Business Days
Immunogen 17 amino acid synthetic peptide near the center of Human CLEC7A
Isotype IgG
Specificity Multiple isoforms of CLEC7A are known to exist.
Purification Affinity chromatography purified via peptide column
Alternative Name CLEC7A / Dectin-1
Background CLEC7A, also known as dectin-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily and is predominantly expressed on myeloid cells. It is a small glycoprotein type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM). CLEC7A functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, triggering a massive oxidative burst through the formation of reactive oxygen species.
Alternate names: BGR, Beta-glucan receptor, C-type lectin domain family 7 member A, C-type lectin superfamily member 12, CLECSF12, DC-associated C-type lectin 1, DECTIN1, Dendritic cell- associated C-type lectin 1
Gene ID 64581
NCBI Accession NP_922938
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% Sodium Azide as preservative
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Taylor, Brown, Reid et al.: "The beta-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 7, pp. 3876-82, 2002 (PubMed).

Ebner, Sharon, Ben-Tal: "Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily." in: Proteins, Vol. 53, Issue 1, pp. 44-55, 2003 (PubMed).

Underhill, Rossnagle, Lowell et al.: "Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production." in: Blood, Vol. 106, Issue 7, pp. 2543-50, 2005 (PubMed).

Kerrigan, Brown: "Syk-coupled C-type lectin receptors that mediate cellular activation via single tyrosine based activation motifs." in: Immunological reviews, Vol. 234, Issue 1, pp. 335-52, 2010 (PubMed).

Alternatives for antigen "C-Type Lectin Domain Family 7, Member A (CLEC7A)", type "Antibodies"
Hosts (33), (27), (26)
Reactivities (53), (50), (17), (1)
Applications (56), (17), (12), (10), (9), (8), (8), (6), (3), (3), (2), (1)
Conjugates (18), (6), (5), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (12), (4), (3), (2), (2), (1), (1)
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