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C-Type Lectin Domain Family 7, Member A (CLEC7A) (Middle Region) antibody

Details for Product No. ABIN1449932, Supplier: Login to see
Antigen
  • CLEC7A
  • BGR
  • Clecsf12
  • beta-GR
  • CANDF4
  • CLECSF12
  • DECTIN1
  • Clec7b
  • RGD1565140
Epitope
Middle Region
17
8
8
5
3
2
2
2
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
111
92
19
4
1
Host
Rabbit
66
61
55
Clonality
Polyclonal
Conjugate
Un-conjugated
35
24
12
7
4
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
120
38
25
20
20
13
13
11
9
4
2
Supplier
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Immunogen 17 amino acid synthetic peptide near the center of Human CLEC7A
Isotype IgG
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse, Rat.
Purification Affinity chromatography purified via peptide column
Alternative Name CLEC7A / Dectin-1 (CLEC7A Antibody Abstract)
Background CLEC7A, also known as dectin-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily and is predominantly expressed on myeloid cells. It is a small glycoprotein type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM). CLEC7A functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, triggering a massive oxidative burst through the formation of reactive oxygen species.Synonyms: BGR, Beta-glucan receptor, C-type lectin domain family 7 member A, C-type lectin superfamily member 12, CLECSF12, DC-associated C-type lectin 1, DECTIN1, Dendritic cell-associated C-type lectin 1
Gene ID 64581
NCBI Accession NP_922938
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-C-Type Lectin Domain Family 7, Member A (CLEC7A) (Middle Region) antibody (ABIN1449932) Immunohistochemistry of CLEC7A in human spleen tissue with CLEC7A antibody at 5 µg/ml.
Western Blotting (WB) image for anti-C-Type Lectin Domain Family 7, Member A (CLEC7A) (Middle Region) antibody (ABIN1449932) Western blot analysis of CLEC7A in rat spleen tissue lysate with CLEC7A antibody at (...
Background publications Kerrigan, Brown: "Syk-coupled C-type lectin receptors that mediate cellular activation via single tyrosine based activation motifs." in: Immunological reviews, Vol. 234, Issue 1, pp. 335-52, 2010 (PubMed).

Underhill, Rossnagle, Lowell et al.: "Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production." in: Blood, Vol. 106, Issue 7, pp. 2543-50, 2005 (PubMed).

Ebner, Sharon, Ben-Tal: "Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily." in: Proteins, Vol. 53, Issue 1, pp. 44-55, 2003 (PubMed).

Taylor, Brown, Reid et al.: "The beta-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 7, pp. 3876-82, 2002 (PubMed).