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CLEC7A antibody (Middle Region)

CLEC7A Reactivity: Human, Mouse, Rat WB, IHC (p), IF, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1449932
  • Target See all CLEC7A Antibodies
    CLEC7A (C-Type Lectin Domain Family 7, Member A (CLEC7A))
    Binding Specificity
    • 14
    • 8
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 56
    • 35
    • 5
    • 1
    Human, Mouse, Rat
    Host
    • 40
    • 17
    • 17
    Rabbit
    Clonality
    • 41
    • 28
    Polyclonal
    Conjugate
    • 24
    • 11
    • 9
    • 8
    • 7
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CLEC7A antibody is un-conjugated
    Application
    • 43
    • 37
    • 23
    • 22
    • 8
    • 8
    • 7
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, Mouse, Rat.
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    17 amino acid synthetic peptide near the center of Human CLEC7A
    Isotype
    IgG
    Top Product
    Discover our top product CLEC7A Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS containing 0.02 % Sodium Azide as preservative
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    CLEC7A (C-Type Lectin Domain Family 7, Member A (CLEC7A))
    Alternative Name
    CLEC7A / Dectin-1 (CLEC7A Products)
    Synonyms
    CLEC7A antibody, BGR antibody, Clecsf12 antibody, beta-GR antibody, CANDF4 antibody, CLECSF12 antibody, DECTIN1 antibody, Clec7b antibody, RGD1565140 antibody, C-type lectin domain containing 7A antibody, C-type lectin domain family 7, member a antibody, CLEC7A antibody, Clec7a antibody
    Background
    CLEC7A, also known as dectin-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily and is predominantly expressed on myeloid cells. It is a small glycoprotein type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM). CLEC7A functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, triggering a massive oxidative burst through the formation of reactive oxygen species.Synonyms: BGR, Beta-glucan receptor, C-type lectin domain family 7 member A, C-type lectin superfamily member 12, CLECSF12, DC-associated C-type lectin 1, DECTIN1, Dendritic cell-associated C-type lectin 1
    Gene ID
    64581
    NCBI Accession
    NP_922938
    Pathways
    Activation of Innate immune Response
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