Thymus High Mobility Group Box Protein (TOX) (N-Term) antibody

Details for Product No. ABIN1449998
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Antigen
Synonyms 1700007F02Rik, TOX1
Epitope
N-Term
(8)
Reactivity
Human
(10), (2), (2), (2), (2), (2)
Host
Rabbit
(10)
Clonality
Polyclonal
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), ELISA, Western Blotting (WB)
(10), (5), (2)
Pubmed 4 references available
Catalog no. ABIN1449998
Quantity 0.1 mg
Price
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Immunogen A 17 amino acid synthetic peptide near the amino terminus of Human TOX
Isotype IgG
Specificity This antibody is Human reactive. No alternatively spliced transcript variants have been observed.
Purification Affinity chromatography purified via peptide column
Alternative Name TOX
Background TOX (thymocyte selection-associated high mobility group (HMG) box protein) is a member of the HMG box family of DNA-binding proteins and likely plays a role in the regulation of T- cell development (1,2). It is a 526 amino acid nuclear protein and the expression of TOX is upregulated by pre-T cell receptor (pre-TCR) and TCR activation in immature thymocytes. TOX-mediated positive selection is associated with up-regulation of RUNX3 and is calcineurin dependent. TOX-dependent transition to the CD4+CD8 stage is required for development of class II major histocompatibility complex-specific T cells.
Alternate names: KIAA0808, Thymocyte selection-associated high mobility group box protein TOX, Thymus high mobility group box protein TOX
Gene ID 9760
NCBI Accession NP_055544
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% Sodium Azide as preservative
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Saito, Watanabe: "Positive and negative thymocyte selection." in: Critical reviews in immunology, Vol. 18, Issue 4, pp. 359-70, 1998 (PubMed).

Wilkinson, Chen, Han et al.: "TOX: an HMG box protein implicated in the regulation of thymocyte selection." in: Nature immunology, Vol. 3, Issue 3, pp. 272-80, 2002 (PubMed).

Aliahmad, OFlaherty, Han et al.: "TOX provides a link between calcineurin activation and CD8 lineage commitment." in: The Journal of experimental medicine, Vol. 199, Issue 8, pp. 1089-99, 2004 (PubMed).

Aliahmad, Kadavallore, de la Torre et al.: "TOX is required for development of the CD4 T cell lineage gene program." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 187, Issue 11, pp. 5931-40, 2011 (PubMed).

Hosts (10)
Reactivities (10), (2), (2), (2), (2), (2)
Applications (10), (5), (2)
Epitopes (8)
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