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Thymus High Mobility Group Box Protein (TOX) (N-Term) antibody

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Synonyms TOX1, 1700007F02Rik
(9), (1), (1)
(15), (8), (4), (3), (3), (3)
(15), (3)
(1), (1)
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
(15), (4), (3), (2), (2), (2), (2), (1), (1)
Pubmed 4 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen A 17 amino acid synthetic peptide near the amino terminus of Human TOX
Isotype IgG
Purification Affinity chromatography purified via peptide column
Alternative Name TOX (TOX Antibody Abstract)
Background TOX (thymocyte selection-associated high mobility group (HMG) box protein) is a member of the HMG box family of DNA-binding proteins and likely plays a role in the regulation of T-cell development (1,2). It is a 526 amino acid nuclear protein and the expression of TOX is upregulated by pre-T cell receptor (pre-TCR) and TCR activation in immature thymocytes. TOX-mediated positive selection is associated with up-regulation of RUNX3 and is calcineurin dependent. TOX-dependent transition to the CD4+CD8 stage is required for development of class II major histocompatibility complex-specific T cells.Synonyms: KIAA0808, Thymocyte selection-associated high mobility group box protein TOX, Thymus high mobility group box protein TOX
Molecular Weight 58 kDa
Gene ID 9760
NCBI Accession NP_055544
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-Thymus High Mobility Group Box Protein (TOX) (N-Term) antibody (ABIN1449998) Western blot analysis of TOX in human colon tissue lysate with TOX Antibody  at (A) 1...
Background publications Aliahmad, Kadavallore, de la Torre et al.: "TOX is required for development of the CD4 T cell lineage gene program." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 187, Issue 11, pp. 5931-40, 2011 (PubMed).

Aliahmad, OFlaherty, Han et al.: "TOX provides a link between calcineurin activation and CD8 lineage commitment." in: The Journal of experimental medicine, Vol. 199, Issue 8, pp. 1089-99, 2004 (PubMed).

Wilkinson, Chen, Han et al.: "TOX: an HMG box protein implicated in the regulation of thymocyte selection." in: Nature immunology, Vol. 3, Issue 3, pp. 272-80, 2002 (PubMed).

Saito, Watanabe: "Positive and negative thymocyte selection." in: Critical reviews in immunology, Vol. 18, Issue 4, pp. 359-70, 1998 (PubMed).

Catalog No. ABIN1449998
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