Thymus High Mobility Group Box Protein (TOX) (N-Term) antibody

Details for Product No. ABIN1449998
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Antigen
Synonyms TOX1, 1700007F02Rik
Epitope
N-Term
(9), (1)
Reactivity
Human
(10), (3), (3), (3), (3), (3)
Host
Rabbit
(10)
Clonality
Polyclonal
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
(10), (5), (2)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN1449998
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Immunogen A 17 amino acid synthetic peptide near the amino terminus of Human TOX
Isotype IgG
Purification Affinity chromatography purified via peptide column
Alternative Name TOX
Background TOX (thymocyte selection-associated high mobility group (HMG) box protein) is a member of the HMG box family of DNA-binding proteins and likely plays a role in the regulation of T-cell development (1,2). It is a 526 amino acid nuclear protein and the expression of TOX is upregulated by pre-T cell receptor (pre-TCR) and TCR activation in immature thymocytes. TOX-mediated positive selection is associated with up-regulation of RUNX3 and is calcineurin dependent. TOX-dependent transition to the CD4+CD8 stage is required for development of class II major histocompatibility complex-specific T cells.Synonyms: KIAA0808, Thymocyte selection-associated high mobility group box protein TOX, Thymus high mobility group box protein TOX
Molecular Weight 58 kDa
Gene ID 9760
NCBI Accession NP_055544
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Saito, Watanabe: "Positive and negative thymocyte selection." in: Critical reviews in immunology, Vol. 18, Issue 4, pp. 359-70, 1998 (PubMed).

Wilkinson, Chen, Han et al.: "TOX: an HMG box protein implicated in the regulation of thymocyte selection." in: Nature immunology, Vol. 3, Issue 3, pp. 272-80, 2002 (PubMed).

Aliahmad, OFlaherty, Han et al.: "TOX provides a link between calcineurin activation and CD8 lineage commitment." in: The Journal of experimental medicine, Vol. 199, Issue 8, pp. 1089-99, 2004 (PubMed).

Aliahmad, Kadavallore, de la Torre et al.: "TOX is required for development of the CD4 T cell lineage gene program." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 187, Issue 11, pp. 5931-40, 2011 (PubMed).

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