Podoplanin (PDPN) antibody (Biotin)

Details for Product No. ABIN155160
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Synonyms PDPN, AGGRUS, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A, T1A-2, OTS-8, RANDAM-2, T1-alpha, T1a, T1alpha, E11, RTI40
(125), (47), (19), (1)
(83), (54), (14), (13), (4), (4), (1)
Clonality (Clone)
Monoclonal ()
(8), (6), (5), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Flow Cytometry (FACS)
(103), (46), (43), (42), (31), (26), (24), (23), (9), (9), (1), (1), (1), (1)
Pubmed 6 references available
Quantity 50 μg
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Catalog No. ABIN155160
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Immunogen Podoplanin-expressing MDCK cells.
Clone 18H5
Isotype IgG1
Specificity This antibody reacts with Podoplanin (gp36). The unconjugated monoclonal antibody will detect native Human Podoplanin in Western Blot and on the surface of Human LEC. Species Reactivity: Tested: Human.
Purification Affinity Chromatography on Protein G
Alternative Name Podoplanin
Background Podoplanin (PDPN) is a small mucin-like transmembrane protein, widely expressed in various specialized cell types throughout the body. This is a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. Podoplanin is specifically expressed in the endothelium of lymphatic capillaries but not in the blood v asculature. In normal skin and kidney, podoplanin colocalized with VEGFR3/FLT4, another marker for lymphatic endothelial cells.
Alternate names: Aggrus, GP36, Glycoprotein 36, PA2.26 antigen, PDPN, PSEC0003, PSEC0025, T1-alpha
Gene ID 10630
NCBI Accession NP_001006625
UniProt Q86YL7
Application Notes Flow cytometry: use at 2-5 ug/ml together with the appropriate secondary reagents. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Centrifuge vial prior to opening. Restore in sterile water to a concentration of 0.1-1.0 mg/mL.
Buffer PBS, 0.02% Sodium azide BSA (50x)
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8°C. Following reconstitution store the antibody at -20°C.
Expiry Date 12 months
Product cited in: Kilic, Oliveira-Ferrer, Neshat-Vahid et al.: "Lymphatic reprogramming of microvascular endothelial cells by CEA-related cell adhesion molecule-1 via interaction with VEGFR-3 and Prox1." in: Blood, Vol. 110, Issue 13, pp. 4223-33, 2007 (PubMed).

Conrad, Niess, Huss et al.: "Multipotent mesenchymal stem cells acquire a lymphendothelial phenotype and enhance lymphatic regeneration in vivo." in: Circulation, Vol. 119, Issue 2, pp. 281-9, 2009 (PubMed).

Turner, Langley, Johnston et al.: "Wolbachia lipoprotein stimulates innate and adaptive immunity through Toll-like receptors 2 and 6 to induce disease manifestations of filariasis." in: The Journal of biological chemistry, Vol. 284, Issue 33, pp. 22364-78, 2009 (PubMed).

Background publications Breiteneder-Geleff, Matsui, Soleiman et al.: "Podoplanin, novel 43-kd membrane protein of glomerular epithelial cells, is down-regulated in puromycin nephrosis." in: The American journal of pathology, Vol. 151, Issue 4, pp. 1141-52, 1997 (PubMed).

Zimmer, Oeffner, Von Messling et al.: "Cloning and characterization of gp36, a human mucin-type glycoprotein preferentially expressed in vascular endothelium." in: The Biochemical journal, Vol. 341 ( Pt 2), pp. 277-84, 1999 (PubMed).

Schacht, Ramirez, Hong et al.: "T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema." in: The EMBO journal, Vol. 22, Issue 14, pp. 3546-56, 2003 (PubMed).

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