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Botulinum Neurotoxin Type B (BoNT/B) antibody

BoNT/B Reactivity: Clostridium botulinum cELISA, FACS Host: Mouse Monoclonal GR-3G7 unconjugated
Catalog No. ABIN179725
  • Target See all Botulinum Neurotoxin Type B (BoNT/B) Antibodies
    Botulinum Neurotoxin Type B (BoNT/B)
    Reactivity
    • 5
    • 1
    Clostridium botulinum
    Host
    • 2
    • 2
    • 1
    • 1
    Mouse
    Clonality
    • 3
    • 2
    Monoclonal
    Conjugate
    • 6
    Un-conjugated
    Application
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    Cell-ELISA (cELISA), Flow Cytometry (FACS)
    Specificity
    Anti-BoNT/B
    Purification
    Protein G
    Immunogen
    genetic immunisation with cDNA encoding BoNT/B
    Clone
    GR-3G7
    Isotype
    IgG1
  • Application Notes
    Flow cytometry: 1.2 µg/10^6 cells
    CELISA: 1:200 - 1:400
    For each application a titration should be performed to determine the optimal concentration.
    Restrictions
    For Research Use only
  • Concentration
    2 mg/mL
    Buffer
    PBS, pH 7.2
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C
    Storage Comment
    short term: 2 °C - 8 °C, long term: -20 °C
  • Target
    Botulinum Neurotoxin Type B (BoNT/B)
    Alternative Name
    BoNT B, Lightchain (BoNT/B Products)
    Synonyms
    botulinum neurotoxin type B antibody, botulinum neurotoxin type B, BoNT/B antibody, boNT/B antibody, CLL_0038 antibody
    Target Type
    Bacteria
    Background
    Botulinum neurotoxin type B (BoNT/B) is produced by Clostridium botulinum, a genetically diverse class of anaerobic, spore-forming, gram-positive bacilli. Seven different botulinum toxin groups have been identified serologically and are called botulinum toxin type A,B,C,D,E,F, and G. BoNT/B is a two-chain polypeptide with a 100-kDa heavy chain, which is responsible for neurospecific binding joined by a disulphide bond to a 50-kDa light chain, a zinc-endopeptidase which blocks neurotransmitter release. BoNT/B is one of the most poisonous naturally occurring substances. It inhibits acetylcholine release from neuromuscular junctions while it is used as an important therapeutic mainstay in the treatment of spasticity disorders and as a cosmetic treatment.
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